Navigation Links
Singapore scientists lead human embryonic stem cell study
Date:11/28/2011

Researchers from A*STAR Singapore took lead roles in a study that identified a portion of the genome mutated during long-term culture of human embryonic stem cells (hESCs). The study was a worldwide collaboration, led by Drs Peter Andrews of the University of Sheffield (UK), Paul Robson of the Genome Institute of Singapore (GIS), Steve Oh of Singapore's Bioprocessing Technology Institute (BTI), and Barbara Knowles and others in the international stem cell community. The GIS, IMB and BTI are research institutes under the umbrella of the Agency for Science, Technology and Research, (A*STAR), Singapore.

Involving 125 ethnically diverse hESC lines originating from 38 laboratories globally, and now identified to represent multiple ethnic groups from different parts of the globe, the study is the largest to be conducted on the genetic stability of cultured hESCs. The findings are published today in the journal Nature Biotechnology.

Research into the variability of hESCs is very important as these cells may lead to future cell therapy and regenerative medicine. During long-term culture, however, these cells can acquire genetic changes (mutations), some of which could compromise the cells' utility for regenerative medicine. It is believed that mutations that arise and endure over long-term culture provide a selective advantage for the cells, such as a greater propensity for self renewal.

The study re-emphasized that many chromosome changes occur repeatedly, resulting in increased copies in specific areas of the genome. Interestingly, through molecular karyotyping performed in Dr Robson's laboratory at the GIS, about 20% of the karyotypically normal cell lines exhibited subkaryotypic amplifications of a specific region in chromosome 20. This is also one of the karyotypically defined areas of change. The minimal region common to these cells contains three ES-cell expressed genes, and one of them, BCL2L1, is a strong candidate for drivi
'/>"/>

Contact: Winnie Serah Lim
limcp2@gis.a-star.edu.sg
65-680-88013
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Singapore to hold international pow-wow
2. Singapore Medicine - Breakthrough Development of Cell Therapy Treatment for Cancer
3. Singapore Medicine - Singapore Doctors Use Hi-Tech Implant to Add Space to Narrowed Spinal Canals
4. YM BIOSCIENCES NIMOTUZUMAB SELECTED FOR MULTINATIONAL PHASE III TRIAL BY NATIONAL CANCER CENTRE OF SINGAPORE
5. Alliance Biosciences Announces Trade Mission to Singapore with Speaker Presentation at International Lab Design Seminar
6. S*BIO Receives BioSpectrum Editors Choice, Emerging BioScience Company of Singapore Award
7. PAREXEL Receives BioSingapore Award for Best Performing CRO
8. Moleac Named Singapore Entrepreneurial Company of the Year at the Frost & Sullivan Excellence in Healthcare Awards
9. Biomedical Sciences Companies Expanding in Asia Invested More Than US$500 Million in Singapore
10. Pharma and Biotech Companies Plug into Singapores Integrated Research Network
11. ICON Central Laboratories in Singapore Moves to New Facility to Meet Growing Demand
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/20/2015)... and Champaign, IL (PRWEB) April 20, 2015 ... the establishment of its 12th clinical research site: PMG ... Research has assumed operation of the clinical research department ... PMG’s footprint outside the Southeast to a second region ... a 150 multi-specialty physician practice enhances PMG’s access to ...
(Date:4/20/2015)... April 20, 2015  Eli Lilly and Company (NYSE: ... several targeted cancer therapies, reflecting Lilly,s diverse oncology pipeline, ... Meeting 2015, held April 18-22 in Philadelphia ... to Patients" is the theme of this year,s AACR ... to broadening its portfolio of therapies that accelerate the ...
(Date:4/20/2015)... 20, 2015 Sinovac Biotech Ltd. (Nasdaq: SVA), ... announced its unaudited financial results for the fourth quarter ... Fourth Quarter 2014 Financial Highlights(Compared to the fourth quarter ... a decrease of 11.4% from $22.9 million in the ... of H5N1 pandemic influenza vaccine of $0.1 million in ...
(Date:4/18/2015)... , April 18, 2015 ... CRIS ) will be presenting data at ... American Associate of Cancer Research Annual Meeting (April ...      (Logo: http://photos.prnewswire.com/prnh/20130418/608115 ) , ... proprietary Nicotinamide phosphoribosyltransferase (NAMPT) small molecule inhibitors program, ...
Breaking Biology Technology:PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 2PMG Research Announces the Formation of its 12th Site in Champaign-Urbana, IL 3Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 2Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 3Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 4Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 5Lilly Releases Early-Stage Pipeline Data at AACR Annual Meeting 2015 6Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 2Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 3Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 4Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 5Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 6Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 7Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 8Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 9Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 10Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 11Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 12Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 13Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 14Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 15Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 16Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 17Sinovac Reports Unaudited Fourth Quarter and Full Year 2014 Financial Results 18Aurigene to Present its NAMPT and IRAK-4 Inhibitors Programs at AACR 2015 2
... 4 Imaging,Diagnostic Systems, Inc., (OTC Bulletin Board: ... systems, has shipped a CT Laser Mammography,(CTLM(R)) system ... Lumpur,Malaysia, the first such scanner in the country. ... CTLM system will be installed at UPM,s academic ...
... PHRM ) today announced that Erle Mast, the Company,s ... corporate overview at,the Bear Stearns 2007 Healthcare Conference in ... 4:00 p.m. (Eastern) on Monday,September 10, 2007 at the ... will be a live webcast of the presentation from ...
... and Advisor to ForSight ... ... Morgenthaler Ventures, (http://www.morgenthaler.com/ventures ), a leading venture capital firm focused ... Plain as partner in its Menlo Park office. Plain brings,significant entrepreneurial ...
Cached Biology Technology:Imaging Diagnostic Systems New Laser Breast Imaging Scanner Introduced in Malaysia 2Hank Plain Joins Morgenthaler Ventures as Partner 2Hank Plain Joins Morgenthaler Ventures as Partner 3
(Date:4/13/2015)... , April 13, 2015 ... Research, "Global Biometrics Market Forecast & Opportunities, 2020", the ... CAGR of around 14% till 2020. The biometrics ... large scale implementation and review of biometric management ... of new products with greater efficiency, are resulting ...
(Date:4/9/2015)... Calif. , April 9, 2015 Synaptics ... interface solutions, announced today that it will report financial ... Thursday, April 23, 2015, after the close of market. ... analysts and investors at 2:00 p.m. PT (5:00 p.m. ... To participate on the live call, analysts ...
(Date:4/2/2015)... , April 2, 2015 ... tests DERMALOG by far outperforms the strongest competitors, ... maintaining high accuracy, the system is capable of ... the speed proves up to be ten times ... than its runner-up performance.      (Photo: ...
Breaking Biology News(10 mins):Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2Synaptics to Report Third Quarter Results on April 23 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 2DERMALOG AFIS Emerges as Performance Winner in NIST Benchmark Test 3
... harmful to wild fish, according to an essay in this ... Neil Frazer of the Department of Geology and Geophysics at ... cause nearby wild fish to decline. The foundation of his ... infection lowers the fitness of the fish. For ...
... The elevated carbon dioxide levels expected to be found in ... impairments of jumbo (or Humboldt) squid, according to research by ... study by Brad Seibel, URI assistant professor of biological sciences, ... the faculty at the University of Lisbon, Portugal, is reported ...
... a patient-centered, care management program utilizing nurse care managers ... coordination systems reduce the rate of deaths and hospitalizations ... based on a three-year study involving more than 3,400 ... University researcher David A. Dorr, M.D. appears to ...
Cached Biology News:Ocean fish farming harms wild fish, study says 2Ocean acidification from CO2 emissions will cause physiological impairment to jumbo squid 2Proactive care saves lives of seniors, study finds 2Proactive care saves lives of seniors, study finds 3
... are preactivated with carbonyl diimidazole chemistry that ... The PS10 array contains the same binding ... with an updated hydrophobic barrier coating. These ... mm diameter spots spatially compatible with one ...
... Second Mitochondria Derived Activator of Caspase/DIABLO ... mM HEPES, pH 7.5 AVOID FREEZE/THAW CYCLES. Amino ... with a carboxy terminal His•Tag ® sequence ... coli . Smac/DIABLO is released along with cytochrome ...
...
... Fixed clamp trays and universal ... Magnetic drive Shaking ... 25 mm amplitude ... to 2000 ml, including Fernbach flasks ...
Biology Products: