Navigation Links
Singapore scientists lead human embryonic stem cell study
Date:11/28/2011

Researchers from A*STAR Singapore took lead roles in a study that identified a portion of the genome mutated during long-term culture of human embryonic stem cells (hESCs). The study was a worldwide collaboration, led by Drs Peter Andrews of the University of Sheffield (UK), Paul Robson of the Genome Institute of Singapore (GIS), Steve Oh of Singapore's Bioprocessing Technology Institute (BTI), and Barbara Knowles and others in the international stem cell community. The GIS, IMB and BTI are research institutes under the umbrella of the Agency for Science, Technology and Research, (A*STAR), Singapore.

Involving 125 ethnically diverse hESC lines originating from 38 laboratories globally, and now identified to represent multiple ethnic groups from different parts of the globe, the study is the largest to be conducted on the genetic stability of cultured hESCs. The findings are published today in the journal Nature Biotechnology.

Research into the variability of hESCs is very important as these cells may lead to future cell therapy and regenerative medicine. During long-term culture, however, these cells can acquire genetic changes (mutations), some of which could compromise the cells' utility for regenerative medicine. It is believed that mutations that arise and endure over long-term culture provide a selective advantage for the cells, such as a greater propensity for self renewal.

The study re-emphasized that many chromosome changes occur repeatedly, resulting in increased copies in specific areas of the genome. Interestingly, through molecular karyotyping performed in Dr Robson's laboratory at the GIS, about 20% of the karyotypically normal cell lines exhibited subkaryotypic amplifications of a specific region in chromosome 20. This is also one of the karyotypically defined areas of change. The minimal region common to these cells contains three ES-cell expressed genes, and one of them, BCL2L1, is a strong candidate for drivi
'/>"/>

Contact: Winnie Serah Lim
limcp2@gis.a-star.edu.sg
65-680-88013
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Singapore to hold international pow-wow
2. Singapore Medicine - Breakthrough Development of Cell Therapy Treatment for Cancer
3. Singapore Medicine - Singapore Doctors Use Hi-Tech Implant to Add Space to Narrowed Spinal Canals
4. YM BIOSCIENCES NIMOTUZUMAB SELECTED FOR MULTINATIONAL PHASE III TRIAL BY NATIONAL CANCER CENTRE OF SINGAPORE
5. Alliance Biosciences Announces Trade Mission to Singapore with Speaker Presentation at International Lab Design Seminar
6. S*BIO Receives BioSpectrum Editors Choice, Emerging BioScience Company of Singapore Award
7. PAREXEL Receives BioSingapore Award for Best Performing CRO
8. Moleac Named Singapore Entrepreneurial Company of the Year at the Frost & Sullivan Excellence in Healthcare Awards
9. Biomedical Sciences Companies Expanding in Asia Invested More Than US$500 Million in Singapore
10. Pharma and Biotech Companies Plug into Singapores Integrated Research Network
11. ICON Central Laboratories in Singapore Moves to New Facility to Meet Growing Demand
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... a deicing film for radar domes have now refined ... glass. , The new work by Rice chemist ... from windshields to skyscrapers free of ice and fog ... , The technology was introduced this month in the ... . , The material is made of graphene ...
(Date:9/16/2014)... CIRTEC Medical Systems’ Board of Directors has ... CIRTEC. , “I am delighted to be joining ... Brian Highley. “The company has made great strides improving ... over the past two years. The goal now is ... expand the services Cirtec offers its medical device customers.” ...
(Date:9/16/2014)... 16, 2014 Convoy Therapeutics, Inc., ... effective products to treat patients directly at the ... proprietary SPACE™ Technology Platform announced today that John ... present at the White Hat Life Science Investor ... Regency Phoenix. In addition, interested individuals can ...
(Date:9/16/2014)... NEW ORLEANS , Sept. 16, 2014 ... Austin, Texas -based cybersecurity company focused on ... 2FA ONE, will support the ability to generate a ... As a pioneer of user-based RFID authentication, ... used for physical access, for many years. RFID authentication ...
Breaking Biology Technology:Nanoribbon film keeps glass ice-free 2Convoy Therapeutics to Present at WhiteHat Investor Conference September 18, 2014 2Convoy Therapeutics to Present at WhiteHat Investor Conference September 18, 2014 32FA, Inc. Announces RFID-based One-Time Password (OTP) Authentication 2
... New England Biolabs has expanded its line of PCR ... Hot Start DNA Polymerases. Optimized blends of Taq ... offer robust amplification across a wide range of templates, including ... Deep Vent increases the fidelity and robustness of Taq ...
... PARK, N.C., Feb. 14, 2011 India,s premier ... Neurological Society of India & Congress of Neurological ... December.  The event was a convergence of leading ... from across the globe to discuss advances made ...
... Va., Feb. 14, 2011 Technology Catalysts International (TCI), ... research on trends and development in drug delivery have ... drugs with limited patent life, a different pathway for ... product a competitive edge in a crowded pharmaceutical field. ...
Cached Biology Technology:New England Biolabs Introduces OneTaq™ DNA Polymerase, a Robust Solution for Routine and Difficult PCR 2Max Neeman International Initiates Advisory Committee to Advance and Improve the Conduct of Complex Neurological Trials in India 2Parenteral Depots Offer $8 Billion of Reformulation Opportunities and a Strong Competitive Edge in Crowded Pharmaceutical Space 2
(Date:9/17/2014)... MSSA could be curbed by coating hospital surfaces ... of shark skin, according to research published in ... Infection Control . , The study modelled how ... disease bacteria through touching, sneezes or spillages. The ... formulated to resemble shark skin. The study showed ...
(Date:9/16/2014)... 2014)More than $100 trillion in cumulative public and ... dioxide (CO2)a 40 percent reduction of urban passenger ... world expands public transportation, walking and cycling in ... the University of California, Davis, and the Institute ... Further, an estimated 1.4 million early deaths could ...
(Date:9/16/2014)... viruses that make us sick can take up residence ... sneeze, cough or other troublesome symptom, according to new ... Louis. , On average, healthy individuals carry about ... report online in BioMed Central Biology . The ... diversity of viruses in healthy people. , The ...
Breaking Biology News(10 mins):Sharks' skin has teeth in the fight against hospital superbugs 2Global shift away from cars saves US$100 trillion, eliminates 1,700 MT of CO2 pollution 2Global shift away from cars saves US$100 trillion, eliminates 1,700 MT of CO2 pollution 3Global shift away from cars saves US$100 trillion, eliminates 1,700 MT of CO2 pollution 4Global shift away from cars saves US$100 trillion, eliminates 1,700 MT of CO2 pollution 5Healthy humans make nice homes for viruses 2Healthy humans make nice homes for viruses 3
... While newly published research confirms that under laboratory circumstances prion-protein ... this is unlikely to occur in real life. In addition, ... do take up these disease-associated proteins are different from the ... will be published in the Journal of Pathology. , Since ...
... & Science University researchers gather a princely sum of ... , Scientists in the OHSU School of Medicine's ... to report a new approach using eggs of the ... Xenopus laevis, to understand how the Fanconi anemia proteins ...
... mixing of pasta metaphors, Pacific Northwest National Laboratory ... biological molecules lasagna-like around spaghetti-like carbon nanotubes. ... of applications, from ultra-precise blood-sugar monitoring to infectious-agent ... at the Department of Energy campus' W.R. Wiley ...
Cached Biology News:New evidence questions the simple link between prion proteins and madcow disease 2New evidence questions the simple link between prion proteins and madcow disease 3Clawed frog helps Fanconi anemia research make leaps 2Clawed frog helps Fanconi anemia research make leaps 3A biosensor layered like lasagna 2
Thermo Forma provides an array of accessory Racks for the Cryo/CryoPlus 16" Diameter storage system. To maximise inventory capacity a Jumbo Arrowhead configuration is recommended. You may choose betw...
... shakers combine high durability and capacity with ... heavy-duty mechanism prevents vibration, allowing the unit ... Every other part, from the large rubber ... machined aluminum platform is designed to last ...
The Holten Horizontal series of laminar airflow work benches offers comfort and ease of use....
... Forma Incubated Orbital Shakers combine ... temperature performance and ease of use. ... vibration, allowing the unit to run ... loads. The unit's class-leading temperature range ...
Biology Products: