Navigation Links
Sigma-Aldrich Joins Phase 2 of The RNAi Consortium to Validate shRNA Libraries
Date:5/7/2008

Sigma-Aldrich to Provide Full Functional Validation Data for Its MISSION(R)

shRNA Collection

ST. LOUIS, May 7 /PRNewswire-FirstCall/ -- Sigma-Aldrich(TM) (Nasdaq: SIAL) and the second phase of The RNAi Consortium (TRC2) have commenced functional validation of the Consortium's collection of approximately 160,000 previously-cloned lentiviral-based shRNA vector constructs. Currently, more than 5,000 clones have been tested in the functional validation process. Validated clones covering more than 700 genes are available in Sigma-Aldrich's MISSION(R) shRNA collection, a number expected to grow by 75,000 clones per year through 2011. TRC2 will also generate and validate 150,000 additional clones and utilize its collection of validated shRNA libraries to develop new and improved RNAi screening strategies.

Design and development of TRC libraries is led by the Broad Institute of MIT and Harvard. A key goal of the Consortium is to provide at least two clones with a knockdown level of 70% or greater for every human and mouse gene over the next four years. Research will also center on alternative vector development and improved design, with the possible creation of sub-libraries. Functional validation of these knockdown clones will provide significant time and cost savings to researchers by reducing the number of wells to screen, facilitating improved throughput. The total TRC shRNA collection will eventually comprise 300,000 pre-cloned lentiviral-based shRNA vector constructs targeting the human and mouse genomes.

Sigma-Aldrich's MISSION(R) shRNA portfolio is the exclusive source for researchers to access TRC and TRCII shRNA libraries in the plasmid DNA and lentiviral formats. All of the shRNA reagents will be fully functionally validated during phase 2 of The RNAi Consortium. This validation data will be accessible to customers by request, and online, making the MISSION(R) portfolio the only commercially available set of
'/>"/>

SOURCE Sigma-Aldrich
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Sigma-Aldrich to Present at the Baird 2008 Growth Stock Conference on Tuesday, May 13, 2008
2. Sigma-Aldrich to Present at the Bank of America 2008 Healthcare Conference on Tuesday, May 13, 2008
3. Sigma-Aldrich Announces the Integration of Riedel-De Haen Into Core Product Brands
4. Sigma-Aldrich (Nasdaq: SIAL) Raises 2008 Diluted EPS Forecast by $.05 to $2.57-$2.67. Reports Q1 2008 Diluted EPS Up 14.3%; Sales Gain of 14.9%.
5. Sigma-Aldrich Corporation 1st Quarter 2008 Earnings Conference Call
6. Sigma-Aldrich Partners With Sunset Molecular Discovery to Expand Your Favorite Gene Search Tool
7. Sigma-Aldrich To Hold Annual Business Review
8. Sigma-Aldrich, Oxford BioMedica and Open Biosystems Settle Patent Dispute Over Use of LentiVector Technology in Research Reagents
9. Sigma-Aldrich and MorphoSys Enter Into a Collaboration and Licensing Agreement for Recombinant Research Antibodies
10. Sigma-Aldrich Names Helge Bastian New VP of Global Marketing for Research Biotech
11. Sigma-Aldrich Announces New Prestige Antibodies(TM) Line for Proteomics and Cell Biology Researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... WI (PRWEB) January 22, 2015 Dr. Greg ... the 12th annual Scripps Natural Supplements Pre-Conference seminar on probiotics ... Conference is an annual continuing education conference for health care ... and included the topic of probiotics in health. Dr. Leyer ...
(Date:1/22/2015)... 2015   Cypher Genomics, Inc., the leading ... SQNM ), the leading molecular diagnostics company, ... noninvasive prenatal tests (NIPT). Through this agreement, Sequenom ... to advance analysis of clinically-relevant fetal sub-chromosomal variants ...
(Date:12/24/2014)... SILVER SPRING, Md. , Dec. 24, 2014  United ... that Medtronic, Inc. (NYSE: MDT ) has ... and Drug Administration (FDA) for the use of Medtronic,s ... a newly developed catheter) for use with United Therapeutics, ...
(Date:12/24/2014)... 23, 2014 GMO corn cases filed across ... in the process of being consolidated in a Kansas federal ... Syngenta AG MIR 162 Corn Litigation, MDL No. 2591 in ... Management of the Syngenta GMO corn multidistrict litigation (MDL) has ...
Breaking Biology Technology:Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 2United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 3United Therapeutics Announces Submission Of Pre-Market Approval Application For Implantable Drug Infusion System To Deliver Remodulin 4Carey Danis & Lowe Reports on Syngenta GMO Corn Transfer Order 2
... . From the motion sensor to the ... are used whose functioning is based on smallest structures of ... millimetres. These micro and nano structures must be manufactured and ... the overall system will function smoothly. Thereby, details are important ...
... OmniGuide, Inc., the developer of the first and only ... technology, today announced the results of a pre-clinical study ... in neurosurgery. In the study, surgeons from the Barrow ... in live brain tissue with fiber delivered CO2 laser ...
... HARBIN, China, July 6 /PRNewswire-Asia-FirstCall/ -- China ... a vertically integrated grower,developer, manufacturer and marketer ... that it has retained the services of ... China Kangtai will be,available through the Hawk ...
Cached Biology Technology:Nano measurement in the third dimension 2New Pre-Clinical Data on OmniGuide's BeamPath NEURO(TM) Demonstrates Precise Cutting in Brain Tissue 2New Pre-Clinical Data on OmniGuide's BeamPath NEURO(TM) Demonstrates Precise Cutting in Brain Tissue 3China Kangtai Cactus Biotech Retains Hawk Associates for Investor Relations Services 2China Kangtai Cactus Biotech Retains Hawk Associates for Investor Relations Services 3
(Date:1/22/2015)... , Jan. 13, 2015 /PRNewswire/ - Today, FindBiometrics, the leading ... the launch of its new website design. "When ... its infancy", says Peter O,Neill , founder and CEO ... the industry needs involvement from the key players on a ...
(Date:1/22/2015)... , Jan. 16, 2015  A man-made form of insulin ... other mental capabilities in adults with mild cognitive impairment ... led by researchers at Wake Forest Baptist Medical Center. ... with amnesic mild cognitive impairment (MCI) or mild to ...
(Date:1/22/2015)... 2015 , Europe,s ... The European Patent Office to present a video retrospective of the ... be featured: Christofer Toumazou and Sophie Wilson   ... winners of the Award   Starting on 22 January ...
Breaking Biology News(10 mins):Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3
... WEST LAFAYETTE, Ind. - A new technology enabling ... could make possible super-accurate and precise sensors for ... The innovation might enable researchers to create a ... hazardous solid or gaseous substances, as well as ...
... 10, 2010 Eurofins MWG Operon, international market leader and ... Limited (RCUK SSC Ltd) have signed a three year contract ... long term contract builds on the relationship developed as a ... previous four years. RCUK SSC Ltd has been ...
... usually don,t die from a heart attack. But the damage ... to congestive heart failure, the most common cause of death ... for achieving what the body can,t do: mending broken hearts. ... a scaffold that supports the growth and integration of stem ...
Cached Biology News:Innovation could bring super-accurate sensors, crime forensics 2Innovation could bring super-accurate sensors, crime forensics 3Innovation could bring super-accurate sensors, crime forensics 4A strategy to fix a broken heart 2A strategy to fix a broken heart 3
The iEMS Incubator/Shaker is a high performance microplate incubator and orbital shaker. Its superior temperature control and efficient orbital shaking reduce incubation times. It can incubate up to ...
The iEMS Incubator/Shaker is a high performance microplate incubator and orbital shaker. Its superior temperature control and efficient orbital shaking reduce incubation times. -...
... called a ?cap? is present on ... mRNAs and many viral RNAs. Substitution ... of the GTP present in an ... the synthesis of transcripts with a ...
Improve inventory management with stainless steel red cell canisters; ensure product safety with CO2 or LN2 backup systems. A complete solution for your blood banking needs....
Biology Products: