Navigation Links
Sigma-Aldrich Joins Phase 2 of The RNAi Consortium to Validate shRNA Libraries
Date:5/7/2008

Sigma-Aldrich to Provide Full Functional Validation Data for Its MISSION(R)

shRNA Collection

ST. LOUIS, May 7 /PRNewswire-FirstCall/ -- Sigma-Aldrich(TM) (Nasdaq: SIAL) and the second phase of The RNAi Consortium (TRC2) have commenced functional validation of the Consortium's collection of approximately 160,000 previously-cloned lentiviral-based shRNA vector constructs. Currently, more than 5,000 clones have been tested in the functional validation process. Validated clones covering more than 700 genes are available in Sigma-Aldrich's MISSION(R) shRNA collection, a number expected to grow by 75,000 clones per year through 2011. TRC2 will also generate and validate 150,000 additional clones and utilize its collection of validated shRNA libraries to develop new and improved RNAi screening strategies.

Design and development of TRC libraries is led by the Broad Institute of MIT and Harvard. A key goal of the Consortium is to provide at least two clones with a knockdown level of 70% or greater for every human and mouse gene over the next four years. Research will also center on alternative vector development and improved design, with the possible creation of sub-libraries. Functional validation of these knockdown clones will provide significant time and cost savings to researchers by reducing the number of wells to screen, facilitating improved throughput. The total TRC shRNA collection will eventually comprise 300,000 pre-cloned lentiviral-based shRNA vector constructs targeting the human and mouse genomes.

Sigma-Aldrich's MISSION(R) shRNA portfolio is the exclusive source for researchers to access TRC and TRCII shRNA libraries in the plasmid DNA and lentiviral formats. All of the shRNA reagents will be fully functionally validated during phase 2 of The RNAi Consortium. This validation data will be accessible to customers by request, and online, making the MISSION(R) portfolio the only commercially available set of
'/>"/>

SOURCE Sigma-Aldrich
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Sigma-Aldrich to Present at the Baird 2008 Growth Stock Conference on Tuesday, May 13, 2008
2. Sigma-Aldrich to Present at the Bank of America 2008 Healthcare Conference on Tuesday, May 13, 2008
3. Sigma-Aldrich Announces the Integration of Riedel-De Haen Into Core Product Brands
4. Sigma-Aldrich (Nasdaq: SIAL) Raises 2008 Diluted EPS Forecast by $.05 to $2.57-$2.67. Reports Q1 2008 Diluted EPS Up 14.3%; Sales Gain of 14.9%.
5. Sigma-Aldrich Corporation 1st Quarter 2008 Earnings Conference Call
6. Sigma-Aldrich Partners With Sunset Molecular Discovery to Expand Your Favorite Gene Search Tool
7. Sigma-Aldrich To Hold Annual Business Review
8. Sigma-Aldrich, Oxford BioMedica and Open Biosystems Settle Patent Dispute Over Use of LentiVector Technology in Research Reagents
9. Sigma-Aldrich and MorphoSys Enter Into a Collaboration and Licensing Agreement for Recombinant Research Antibodies
10. Sigma-Aldrich Names Helge Bastian New VP of Global Marketing for Research Biotech
11. Sigma-Aldrich Announces New Prestige Antibodies(TM) Line for Proteomics and Cell Biology Researchers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... Brady (NYSE:BRC), a global ... a new video testimonial on the effectiveness ... a research technician at the BloodCenter of Wisconsin discusses ... and storing hundreds of thousands of samples, and how ... , “At Brady, we design our label materials with ...
(Date:10/31/2014)... 2014  Tavistock Development Co. (TDC), a diversified ... groundbreaking of the GuideWell Innovation Center ... The 92,000-square-foot, three-story facility is the first multi-tenant ... designed specifically for life sciences, health innovation, and ... 650-acre Lake Nona Medical City, near the Sanford-Burnham ...
(Date:10/30/2014)... Investor-Edge has initiated coverage on the following ... (NASDAQ: MDVN ), Pharmacyclics Inc. (NASDAQ: ... and Ironwood Pharmaceuticals Inc. (NASDAQ: IRWD). Free research on ... . On Wednesday, October 29, 2014, the ... Jones Industrial Average declined 0.18%, to finish the day ...
(Date:10/30/2014)... Dallas, Texas (PRWEB) October 30, 2014 ... China Naltrexone HCL Industry” is a professional and ... The report provides basic Naltrexone HCL information, including ... as well as industry overview. This research covers ... as well as global industry analysis covering macroeconomic ...
Breaking Biology Technology:Brady Debuts New Lab Label Testimonial Video 2GuideWell Innovation Center Groundbreaking Hosted by Tavistock Development Company at Lake Nona Medical City 2GuideWell Innovation Center Groundbreaking Hosted by Tavistock Development Company at Lake Nona Medical City 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 2Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 4Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 5Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3
... second time in six years, a Madison software company ... ,This time Hyperphrase Technologies has filed suit against ... allegedly using technology that provides viewers of a Web ... claims that Google Toolbar features AutoLink and AdSense have ...
... A crowd wearing paper goggles gasped frequently as they ... image sent live from La Crosse to Madison. , , ... 3D with one of the applications he's developed at UW-La ... that could form the foundation for educational software on anatomy. ...
... - With the deployment of Internet Protocol telephony gaining ... have been added to the Wisconsin product line of ... ,With the addition of the Cisco premise-based system, the ... both a hosted and premise-based vendor at a time ...
Cached Biology Technology:Next generation simulations? Not on the Internet you're used to 2Norlight adds Cisco-based IP systems in Wisconsin 2
(Date:10/31/2014)... New Haven, Conn. – Geologists are letting the air out ... on Earth. , Scientists have long speculated as to why ... Earth,s surface. Animals began to prosper at the end of ... what about the billion-year stretch before that, when most researchers ... seems the air wasn,t so great then, after all. , ...
(Date:10/31/2014)... good for attracting species, but it may not be enough ... study has found. , The researchers surveyed two types of ... abundance of two insects that interact with them. They found ... and black walnut, they didn,t find a corresponding abundance of ... the walnuts and black cherries and a type of wasp ...
(Date:10/31/2014)... Melbourne researchers have uncovered key steps involved in programmed ... diseases including lupus, cancers and neurodegenerative diseases. , ... Institute worked together to discover the three-dimensional structure of ... the first steps in how it causes cell death. ... and Proceedings of the National ...
Breaking Biology News(10 mins):Lack of oxygen delayed the rise of animals on Earth 2Green spaces don't ensure biodiversity in urban areas 2A matter of life and death: Cell death proteins key to fighting disease 2
... Dr. Ron Koder, assistant professor of physics at The City ... devised a novel method for producing an artificial protein capable ... recently awarded a three-year $1.3 million grant from the U.S. ... be administered to injured troops on the battlefield. "Engineered ...
... & Biotechnology News (GEN) recently co-sponsored a roundtable discussion ... in environment clean-up after manmade or natural disasters. "Gulf ... Impact and to Help in Remediation" was also sponsored ... of Massachusetts Boston, where the discussions took place. Part ...
... on hold until after 40, or even 45, will be ... there are associated risks for babies when postponing child-bearing, the ... Aviv University,s Sackler School of Medicine and the Hospital for ... in Israel, a country that supports in vitro fertilization (IVF) ...
Cached Biology News:CCNY professor gets grant to develop 'artificial blood' 2Rocking the cradle after 45 2