Navigation Links
Sigma-Aldrich Introduces MISSION(R) esiRNA for Low Cost, High Specificity Pooled RNAi Screening
Date:4/28/2009

be partnering with Sigma-Aldrich to make esiRNA technology available to the research community," he said. "esiRNAs were invented in Mike Bishop's laboratory at UCSF almost 10 years ago. esiRNA has been a major research focus of my group ever since. Sigma-Aldrich's extensive experience and product range in RNAi are a perfect complement to our effort to produce efficient and specific esiRNAs."

Harvard Medical School, which has invested in a human genome-wide esiRNA library, is using esiRNA to help identify the human genes that enable HIV propagation. "The phenotypic results from the initial tests of MISSION esiRNA using our assay for finding HIV dependency factors demonstrated very effective knockdown over a wide range of genes," said Dr. Abraham Brass, a clinical research fellow at Harvard Medical School.

Harvard Medical School will soon incorporate the technology into a wider range of tests. Dr. Caroline Shamu, director of the ICCB-Longwood Screening Facility, which provides high-throughput screens of RNAi libraries for Harvard Medical School researchers, said, "We are looking forward to screening the MISSION esiRNA library at ICCB-Longwood."

esiRNA are endoribonuclease-prepared siRNAs synthesized by in vitro transcription of a 300-600-bp gene specific double-stranded RNA, followed by enzymatic digestion. This collection of siRNA-like molecules is then purified, resulting in a complex pool of siRNA molecules all targeting different sequences of a single gene.

For more information on MISSION(R) esiRNA, please visit www.sigma.com/esirna.

About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High Technology company. Its biochemical and organic chemical products and kits are used in scientific research, including genomic and proteomic research, biot
'/>"/>

SOURCE Sigma-Aldrich Corp.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Sigma-Aldrich (Nasdaq: SIAL) Declares Quarterly Dividend
2. Sigma-Aldrich and Lab Manager Magazine Present Webinar On Laboratory Environmental, Health and Safety Compliance Strategies
3. Sigma-Aldrich Expansion in Republic of China to Support SAFC Growth
4. Sigma-Aldrich and Ingenuity Systems Announce Partnership to Create E-Commerce Search Solution Based on Biological Knowledge
5. Sigma-Aldrich to Present at the UBS 2007 Global Life Sciences Conference on September 25, 2007
6. Sigma-Aldrich Names Patrick Sullivan New VP of Research and Development for Research Biotech
7. Sigma-Aldrich and the Universite de Montreal Establish Collaboration for RNA Interference Studies
8. Sigma-Aldrich Corporations 3rd Quarter 2007 Earnings Conference Call
9. Sigma-Aldrich Introduces N-TER Nanoparticle siRNA Transfection System for Delivery of siRNA Into Difficult-to-Transfect Cell Types
10. Sigma-Aldrich (Nasdaq: SIAL) Q3 2007 Sales Increase 14.0%, Yielding Diluted EPS of $.54.
11. Sigma-Aldrich and Oxford BioMedica Win Key Ruling in Open Biosystems Patent Infringement Dispute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... Niagara Thermal Products is proud to announce that ... ("B3") as the critical thermal component supplier in support ... Corps of Engineers.  B3 has developed the only comprehensive ... destroys VOCs and other chemical pollutants, allergens and organic ...
(Date:1/15/2014)... and SAN JOSE, California , ... biotechnology company developing antibody-drug conjugates for cancer, today announced the ... of Directors. Dr Reynolds has over 20 years, development experience ... Officer at Seattle Genetics. "I am delighted to ...
(Date:1/15/2014)... A study has been launched to test ... track could help to tackle the problem of obesity.  This ... GP surgery based in Stowmarket) and academics at University Campus ... Telemetry technology, which is inspired by equipment used to collect ...
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains ... these latent viruses is the Epstein Barr Virus (EBV), and ... (RA) is a chronic inflammatory disease that destroys the body’s ... RA patients have high concentrations of EBV DNA in their ...
Breaking Biology Technology:Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 2Oxford BioTherapeutics Appoints Thomas C Reynolds MD, PhD to its Board of Directors 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 2Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 3Formula 1 Technology Tackles Obesity in Unique Healthcare Partnership 4Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3
... SAN DIEGO, Sept. 4 ADVENTRX Pharmaceuticals,Inc. (Amex: ... company,focused on commercializing proprietary product candidates for the ... Evan M. Levine,ADVENTRX,s chief executive officer is scheduled ... Conference on Monday, September 10th, 2007,at 8:30 a.m. ...
... Sept. 4 Six hospitals in,the north of ... VAR ),software system that enables them to ... for Medical Oncology at hospitals in Lancashire and,Cumbria ... efficiency by,fully integrating the prescribing, preparation, dispensing and,administration ...
... at Event in ... Hong Kong, China, ... that the leading China biometrics company Miaxis,Biometrics Co., Ltd has been ... 2007 awards. The news has been,announced at a gala dinner during ...
Cached Biology Technology:ADVENTRX Pharmaceuticals to Present at the 20th Annual Bear Stearns Healthcare Conference 2Six UK Hospitals Join Together in Using Varian Medical Oncology Information Network 2Six UK Hospitals Join Together in Using Varian Medical Oncology Information Network 3Miaxis Biometrics Named as 'Red Herring 100 Asia' Award Winner for 2007 2Miaxis Biometrics Named as 'Red Herring 100 Asia' Award Winner for 2007 3
(Date:4/21/2014)... 21, 2014 Performing brain research that can one ... of Houston (UH) junior Khanh (Kate) Nguyen has been ... A double major in mathematics and physics, Nguyen is ... Scholarship. , One of the most prestigious awards ... to sophomore and junior students majoring in mathematics, the ...
(Date:4/21/2014)... Earth Week--and in fact, every week now--trees in mountains across ... of bark beetles that reproduce in the trees, inner bark. ... mountain pine beetle, attack and kill live trees. Others live ... the mountain pine beetle has caused the deaths of more ... do all these dead trees have on stream flow and ...
(Date:4/21/2014)... Boobies are on the decline in the Galpagos. , A ... Ecology indicates numbers of the iconic birds, known for ... to attract mates, have fallen more than 50 percent in ... population is probably due to an unexplained disappearance of sardines ... biology at Wake Forest University and the study,s principal investigator. ...
Breaking Biology News(10 mins):UH student named Goldwater Scholar, 2 more receive honorable mention 2UH student named Goldwater Scholar, 2 more receive honorable mention 3UH student named Goldwater Scholar, 2 more receive honorable mention 4Earth Week: Bark beetles change Rocky Mountain stream flows, affect water quality 2Earth Week: Bark beetles change Rocky Mountain stream flows, affect water quality 3Lack of breeding threatens blue-footed boobies' survival 2Lack of breeding threatens blue-footed boobies' survival 3
... Hebrew University of,Jerusalem have succeeded in discovering and ... special structural and qualitative,characteristics that could have consequences ... cancer cells.,In addition to being obtained from plant ... large quantities as a recombinant protein in,bacteria, making ...
... the Hebrew University of,Jerusalem have succeeded in discovering ... with special structural and qualitative,characteristics that could have ... to cancer cells.,In addition to being obtained from ... in large quantities as a recombinant protein in,bacteria, ...
... GTP, a related energy currency) and transform it into ... dynein, proteins that use ATP to ferry intracellular cargo ... ATP-dependent assembly of actin or tubulin fibers itself can ... white blood cells toward pathogens is powered by the ...
Cached Biology News:The death of a very special chimpanzee 2New protein discovered by Hebrew University researchers 2DNA Recombination and Repair—A New Twist to RecA Function 2
... Hybri-slips are hydrophobic cover slips for ... to genomic arrays on glass slides., ... slips, Hybri-slips do not adsorb probes. ... prior to use. , Avoid RNA ...
These 22x40mm rectangular No.1 Corning cover glasses are made from No. 0211 zinc titania glass and are 0.16 to 0.19mm thick. • Approx. Pcs Oz : 73...
... in the Microsart e.motion are sterile-sealed, without protective ... specially designed individual package on a band. ... membrane filter units ensures that they are perfectly ... band guarantees uniform dispensing of the individual membrane ...
...
Biology Products: