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Sigma-Aldrich Introduces MISSION(R) esiRNA for Low Cost, High Specificity Pooled RNAi Screening
Date:4/28/2009

be partnering with Sigma-Aldrich to make esiRNA technology available to the research community," he said. "esiRNAs were invented in Mike Bishop's laboratory at UCSF almost 10 years ago. esiRNA has been a major research focus of my group ever since. Sigma-Aldrich's extensive experience and product range in RNAi are a perfect complement to our effort to produce efficient and specific esiRNAs."

Harvard Medical School, which has invested in a human genome-wide esiRNA library, is using esiRNA to help identify the human genes that enable HIV propagation. "The phenotypic results from the initial tests of MISSION esiRNA using our assay for finding HIV dependency factors demonstrated very effective knockdown over a wide range of genes," said Dr. Abraham Brass, a clinical research fellow at Harvard Medical School.

Harvard Medical School will soon incorporate the technology into a wider range of tests. Dr. Caroline Shamu, director of the ICCB-Longwood Screening Facility, which provides high-throughput screens of RNAi libraries for Harvard Medical School researchers, said, "We are looking forward to screening the MISSION esiRNA library at ICCB-Longwood."

esiRNA are endoribonuclease-prepared siRNAs synthesized by in vitro transcription of a 300-600-bp gene specific double-stranded RNA, followed by enzymatic digestion. This collection of siRNA-like molecules is then purified, resulting in a complex pool of siRNA molecules all targeting different sequences of a single gene.

For more information on MISSION(R) esiRNA, please visit www.sigma.com/esirna.

About Sigma-Aldrich: Sigma-Aldrich is a leading Life Science and High Technology company. Its biochemical and organic chemical products and kits are used in scientific research, including genomic and proteomic research, biot
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