Navigation Links
Sigma-Aldrich Introduces MISSION(R) esiRNA for Low Cost, High Specificity Pooled RNAi Screening
Date:4/28/2009

ST. LOUIS, April 28 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL) today announced the global release of MISSION(R) esiRNA, a pool of gene-specific siRNA that provides a novel and powerful approach to RNAi screening in mammalian cells. Unlike traditional synthetic RNAi, esiRNA (http://www.sigma.com/esirna) incorporates a pool of hundreds of siRNAs against a single gene target. This new tool is designed to eliminate the trial and error approach of identifying a single siRNA for gene knockdown and ensures minimal off-target effects.

"MISSION esiRNA provides a powerful way to elucidate gene function in cell culture assays," said Dr. Supriya Shivakumar, global marketing manager for Functional Genomics at Sigma-Aldrich. "The pooled format, unlike anything else on the market, should enable researchers to knock down genes rapidly and cost-effectively. This is an exciting addition to our current MISSION lineup and provides an effective technology that will facilitate RNAi research for a broad base of scientists."

The technique offers a number of benefits over the traditional approach to single-siRNA gene knockdown. By targeting each gene target with a "super-pool" of siRNA, the trial and error approach of identifying a useful single siRNA is eliminated. In addition, the approach should ensure minimal risk of off-target effects and enables the use of one assay per gene. Development of the esiRNA approach was supported by the German BMBF program "GO-Bio" and developed by the Max Planck Institute for Cell Biology and Genetics (MPI-CBG) in Dresden, Germany.

Frank Buchholz, a research group leader at the MPI-CBG, has pioneered the use of the esiRNA technology in RNAi screens. "We are delighted to
'/>"/>

SOURCE Sigma-Aldrich Corp.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Sigma-Aldrich (Nasdaq: SIAL) Declares Quarterly Dividend
2. Sigma-Aldrich and Lab Manager Magazine Present Webinar On Laboratory Environmental, Health and Safety Compliance Strategies
3. Sigma-Aldrich Expansion in Republic of China to Support SAFC Growth
4. Sigma-Aldrich and Ingenuity Systems Announce Partnership to Create E-Commerce Search Solution Based on Biological Knowledge
5. Sigma-Aldrich to Present at the UBS 2007 Global Life Sciences Conference on September 25, 2007
6. Sigma-Aldrich Names Patrick Sullivan New VP of Research and Development for Research Biotech
7. Sigma-Aldrich and the Universite de Montreal Establish Collaboration for RNA Interference Studies
8. Sigma-Aldrich Corporations 3rd Quarter 2007 Earnings Conference Call
9. Sigma-Aldrich Introduces N-TER Nanoparticle siRNA Transfection System for Delivery of siRNA Into Difficult-to-Transfect Cell Types
10. Sigma-Aldrich (Nasdaq: SIAL) Q3 2007 Sales Increase 14.0%, Yielding Diluted EPS of $.54.
11. Sigma-Aldrich and Oxford BioMedica Win Key Ruling in Open Biosystems Patent Infringement Dispute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2015)... , 26. mája 2015 ... mene svojej rodiny prezidentom Barackovi Obamovi a Billovi ... súvislosti so stratou Dr. Rongxiang Xu , ... http://photos.prnewswire.com/prnh/20150522/218111 Dr. Xu bol pionier, ... a jeho odhodlanie v oblasti vedy a príkladné ...
(Date:5/26/2015)... , May 26, 2015  Asterias Biotherapeutics, Inc. (NYSE ... field of regenerative medicine, today announced that all outstanding ... were exercised prior to their expiry on June 15, ... $11.7 million. "We thank our shareholders for ... and CEO of Asterias. "This exercise of warrants represents ...
(Date:5/26/2015)... Fluorinov Pharma (Fluorinov), a FACIT portfolio company, today announced ... its Board of Directors.  His appointment strengthens Fluorinov,s leadership ... accelerates its clinical development activities.  "On ... to welcome Luke to the Board of Directors.  Luke ... strength and success of multiple organizations," said Malik ...
(Date:5/26/2015)... , May 26, 2015 US-Australian drug discovery and development ... it will present at the 2015 Marcum MicroCap Conference ... at the Grand Hyatt Hotel. The ... CEO, is scheduled to begin at 9.30 a.m. ET and will ... to http://wsw.com/webcast/marcum3/nvgn . The annual Marcum MicroCap ...
Breaking Biology Technology:Dr. Rongxiang Xu, O legende 2Asterias Biotherapeutics Receives $11.7 Million in Proceeds from Exercise of Warrants 2Asterias Biotherapeutics Receives $11.7 Million in Proceeds from Exercise of Warrants 3Luke M. Beshar Appointed to Fluorinov Pharma Board of Directors 2Luke M. Beshar Appointed to Fluorinov Pharma Board of Directors 3Novogen to Present at the 2015 Marcum Microcap Conference 2Novogen to Present at the 2015 Marcum Microcap Conference 3Novogen to Present at the 2015 Marcum Microcap Conference 4
... Pivotal Study in, Rituximab Refractory Follicular Non-Hodgkin,s lymphoma ... Number ... Genmab A/S (OMX:,GEN) announced today it has amended the design ... follicular,non-Hodgkin,s lymphoma (NHL) to a single arm trial that will ...
... May Help Increase Appropriate Early Use in Acute Coronary Syndrome ... ... 27 ,Sanofi-aventis (EURONEXT: SAN and NYSE: SNY) and Bristol-Myers Squibb,Company (NYSE: ... approved a supplemental new drug application,(sNDA) for a 300mg tablet of the ...
... ADVENTRX Pharmaceuticals,Inc. (Amex: ANX ), ... commercializing proprietary product candidates for the treatment,of ... data from,preclinical studies of ANX-514 (docetaxel emulsion) ... Cancer Research (AACR), National Cancer,Institute (NCI) and ...
Cached Biology Technology:Genmab Amends Ofatumumab Pivotal Study in NHL to Single Arm Study 2Genmab Amends Ofatumumab Pivotal Study in NHL to Single Arm Study 3FDA Approves New 300mg Loading Dose Tablet for PLAVIX(R) (clopidogrel bisulfate) 2FDA Approves New 300mg Loading Dose Tablet for PLAVIX(R) (clopidogrel bisulfate) 3FDA Approves New 300mg Loading Dose Tablet for PLAVIX(R) (clopidogrel bisulfate) 4FDA Approves New 300mg Loading Dose Tablet for PLAVIX(R) (clopidogrel bisulfate) 5ADVENTRX to Present ANX-514 Preclinical Data at 2007 AACR-NCI-EORTC International Conference 2ADVENTRX to Present ANX-514 Preclinical Data at 2007 AACR-NCI-EORTC International Conference 3ADVENTRX to Present ANX-514 Preclinical Data at 2007 AACR-NCI-EORTC International Conference 4
(Date:5/21/2015)... According to a new ... Software, Services), by Applications (Surveillance (Airborne, Maritime, Land), ... (Military & Defense & Commercial) - Global Forecast ... is expected to grow from $7252.0 Million in ... Compound Annual Growth Rate (CAGR) of 6.6%. ...
(Date:5/20/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... 3D-ID LLC, a company engaged in biometric identification is ... technology portion of the recently awarded TIES (Technical Information ... the Army. 3D-ID LLC has a suite ... enforcement and security agencies. Gino Pereira ...
(Date:5/19/2015)... May 19, 2015 ... the addition of the  "Genetic Testing Market ... (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,A recent report, Genetic ... analysis of the current and future genetic ... tests, their working principles and types are ...
Breaking Biology News(10 mins):Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3Global Genetic Testing Market Outlook 2018 2
... that fish tend to return to the same river where ... State University have determined that the old rule doesn,t always ... Using a statistical analysis of chemicals found in walleye ear ... walleye hatched in the Sandusky and Maumee rivers that returned ...
... scientist has discovered what could be the world,s rarest coral ... elkhorn coral was found while conducting underwater surveys of Arno ... Richards of the ARC Centre of Excellence for Coral Reef ... to the critically endangered and fast-vanishing elkhorn coral ( Acropora ...
... in the 29 July issue of the international journal ... algae known as "phytoplankton" have been declining globally over the ... chain and sustains diverse assemblages of species ranging from tiny ... author Daniel Boyce, "Phytoplankton is the fuel on which marine ...
Cached Biology News:Ear bones reveal spawning secrets of Lake Erie walleye 2Ear bones reveal spawning secrets of Lake Erie walleye 3Ear bones reveal spawning secrets of Lake Erie walleye 4Super-rare 'elkhorn' coral found in Pacific 2Super-rare 'elkhorn' coral found in Pacific 3New study reveals decline of marine phytoplankton over the past century 2
... Collect eliminates manual data entry by ... into any Windows-based application. Collect is ... countless hours of tedious data entry. ... balances, scales, pH meters, spectrophotometers, force gauges, ...
... autofluorescent pigment lipofuscin accumulates in the ... neurons. The presence of lipofuscin granules ... microscopy in the central nervous system ... emission spectra, which overlaps with those ...
DNA sequencing - plasmids or PCR fragments, 3-7 working days service....
Polyclonal Antibody to Golgin-67...
Biology Products: