Navigation Links
Sigma-Aldrich Introduces MISSION(R) esiRNA for Low Cost, High Specificity Pooled RNAi Screening
Date:4/28/2009

ST. LOUIS, April 28 /PRNewswire-FirstCall/ -- Sigma-Aldrich (Nasdaq: SIAL) today announced the global release of MISSION(R) esiRNA, a pool of gene-specific siRNA that provides a novel and powerful approach to RNAi screening in mammalian cells. Unlike traditional synthetic RNAi, esiRNA (http://www.sigma.com/esirna) incorporates a pool of hundreds of siRNAs against a single gene target. This new tool is designed to eliminate the trial and error approach of identifying a single siRNA for gene knockdown and ensures minimal off-target effects.

"MISSION esiRNA provides a powerful way to elucidate gene function in cell culture assays," said Dr. Supriya Shivakumar, global marketing manager for Functional Genomics at Sigma-Aldrich. "The pooled format, unlike anything else on the market, should enable researchers to knock down genes rapidly and cost-effectively. This is an exciting addition to our current MISSION lineup and provides an effective technology that will facilitate RNAi research for a broad base of scientists."

The technique offers a number of benefits over the traditional approach to single-siRNA gene knockdown. By targeting each gene target with a "super-pool" of siRNA, the trial and error approach of identifying a useful single siRNA is eliminated. In addition, the approach should ensure minimal risk of off-target effects and enables the use of one assay per gene. Development of the esiRNA approach was supported by the German BMBF program "GO-Bio" and developed by the Max Planck Institute for Cell Biology and Genetics (MPI-CBG) in Dresden, Germany.

Frank Buchholz, a research group leader at the MPI-CBG, has pioneered the use of the esiRNA technology in RNAi screens. "We are delighted to
'/>"/>

SOURCE Sigma-Aldrich Corp.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Sigma-Aldrich (Nasdaq: SIAL) Declares Quarterly Dividend
2. Sigma-Aldrich and Lab Manager Magazine Present Webinar On Laboratory Environmental, Health and Safety Compliance Strategies
3. Sigma-Aldrich Expansion in Republic of China to Support SAFC Growth
4. Sigma-Aldrich and Ingenuity Systems Announce Partnership to Create E-Commerce Search Solution Based on Biological Knowledge
5. Sigma-Aldrich to Present at the UBS 2007 Global Life Sciences Conference on September 25, 2007
6. Sigma-Aldrich Names Patrick Sullivan New VP of Research and Development for Research Biotech
7. Sigma-Aldrich and the Universite de Montreal Establish Collaboration for RNA Interference Studies
8. Sigma-Aldrich Corporations 3rd Quarter 2007 Earnings Conference Call
9. Sigma-Aldrich Introduces N-TER Nanoparticle siRNA Transfection System for Delivery of siRNA Into Difficult-to-Transfect Cell Types
10. Sigma-Aldrich (Nasdaq: SIAL) Q3 2007 Sales Increase 14.0%, Yielding Diluted EPS of $.54.
11. Sigma-Aldrich and Oxford BioMedica Win Key Ruling in Open Biosystems Patent Infringement Dispute
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)...  Vermillion, Inc. (NASDAQ: VRML ), a ... the next step in its expanded strategy to rebuild ... the naming of current Chief Operating Officer, Valerie ... current Chairman of the Board and CEO James ... changes are effective January 1, 2015. "Jim ...
(Date:12/15/2014)... 2014 METTLER TOLEDO is pleased ... ParticleView V19 with PVM technology , is ... vision and measurement tool continuously captures high-resolution images ... V19 then automatically prepares a report pairing the ... and concentration changes. This compelling blend of high ...
(Date:12/15/2014)... COPENHAGEN, Denmark , Dec. 15, 2014 /PRNewswire/ ... its innovative TransCon technology to address significant unmet ... from its ongoing Phase 2 pediatric study to ... growth hormone deficiency, or GHD.  This interim analysis ... the anticipated total enrollment in the study, completing ...
(Date:12/13/2014)... December 12, 2014 Trend lines for ... overall global economic growth, Eugene Arthurs, CEO of ... said in a featured talk at OPTIC (Optics and ... the National Chung Hsing University in Taichung. , As ... into future energy supplies and soon to hit US$50 ...
Breaking Biology Technology:Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 2Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 3Vermillion Names Valerie Palmieri CEO; James LaFrance to continue as Chairman of Board 4New Real-Time In Situ Probe-Based Video Microscope from METTLER TOLEDO 2Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 2Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 3Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 4Photonics Continues Upward Trends Despite Challenges in the Global Economy, Notes SPIE CEO 5
... RedPrairie Corporation has completed its previously announced acquisition of ... expects to grow to 738 employees at 21 sites ... employees are from MARC. , ,Former MARC CEO Oliver ... organization, under RedPrairie company leader John Jazwiec. , ,"The ...
... an Oracle-based e-mail installation and trying to recover $2.1 ... pilot program that lasted for at least six months ... difficulties cropped up. , ,State CIO Matt Miszewski and ... letter to state agency heads on Friday that the ...
... Amazon.com said on Monday it is acquiring Shopbop, a Madison-based ... up in 1999 as a store on Gorham street called ... as a standalone operation after the acquisition, but Amazon.com will ... not disclosed. With the acquisition, Amazon boosts its selection of ...
Cached Biology Technology:Oracle out, Microsoft in for state e-mail project 2
(Date:11/21/2014)... Strict laws against distracted driving and the ... American and European automotive sector towards gesture recognition technologies. ... that are intuitive and able to retrieve information with ... New analysis from Frost & Sullivan,s Strategic ... Europe and North America ...
(Date:11/18/2014)... , Nov. 18, 2014  The Secure Identity ... Association today jointly announce the formation of The ... of its Identity and Biometric Entry and ... Framework received official support from BORDERPOL, the international ... improve and provide expertise regarding border security, traveler ...
(Date:11/18/2014)... , Nov. 18, 2014   EyeLock Inc. ... solutions, and MorphoTrust USA (Safran), a ... today announced a strategic partnership to offer comprehensive ... vehicle administration (MVA), airport screening and financial services ... solutions, MorphoTrust serves consumers through a nationwide network ...
Breaking Biology News(10 mins):Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3
... SALT LAKE CITY , July 26 Wall Street ... a world leader in content identification solutions, to provide public relations ... in broadcast, government, and professional video trade press worldwide. , ... iPharro Media, based ...
... atmospheric composition, and hence climate. Projections of future climate ... more CO 2 is released from soils in ... due to photosynthesis. Climate changes will also lead to ... methane from wetlands, nitrous oxides from soils, volatile organic ...
... COLUMBUS, Ohio -- Researchers have long known that humans lack ... animal kingdom and even plants -- that reverses severe sun ... this enzyme works at the atomic level to repair sun-damaged ... and skin cancer prevention. In the early online edition ...
Cached Biology News:Wall Street Communications Retained by iPharro Media 2Unaccounted feedbacks from climate-induced ecosystem changes may increase future climate warming 2Researchers discover how key enzyme repairs sun-damaged DNA 2