Navigation Links
Sheffield scientists shine a light on the detection of bacterial infection
Date:12/12/2011

Researchers at the University of Sheffield have developed polymers that fluoresce in the presence of bacteria, paving the way for the rapid detection and assessment of wound infection using ultra-violet light.

When contained in a gel and applied to a wound, the level of fluorescence detected will alert clinicians to the severity of infection. The polymers are irreversibly attached to fragments of antibiotics, which bind to either gram negative or gram positive bacteria both of which cause very serious infections informing clinicians as to whether to use antibiotics or not, and the most appropriate type of antibiotic treatment to prescribe. The team also found that they could use the same gels to remove the bacteria from infected wounds in tissue engineered human skin.

Speaking at the British Science Festival today (15 September), Professor Sheila MacNeil, an expert in tissue engineering and wound healing, explains: "The polymers incorporate a fluorescent dye and are engineered to recognise and attach to bacteria, collapsing around them as they do so. This change in polymer shape generates a fluorescent signal that we've been able to detect using a hand-held UV lamp."

"The availability of these gels would help clinicians and wound care nurses to make rapid, informed decisions about wound management, and help reduce the overuse of antibiotics," says project lead Dr Steve Rimmer.

Currently, determining significant levels of bacterial infection involves swabbing the wound and culturing the swabs in a specialist bacteriology laboratory with results taking several days to be available. The team is confident that its technology can ultimately reduce the detection of bacterial infection to within a few hours, or even less.

The research has already demonstrated that the polymer (PNIPAM), modified with an antibiotic (vancomycin) and containing a fluorescent dye (ethidium bromide), shows a clear fluorescent signal when
'/>"/>

Contact: Jo Kelly
jo@campuspr.co.uk
44-113-357-2100
University of Sheffield
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Sheffield scientists shine a light on the detection of bacterial infection
2. Sheffield Bio-Science Adds Chemically Defined Media Supplements to Product Portfolio
3. Singapore scientists lead human embryonic stem cell study
4. Scientists defuse the Vietnam time bomb
5. Scientists carve nanowires out of ultrananocrystalline diamond thin films
6. Berkeley Lab scientists develop new tool for the study of spatial patterns in living cells
7. Shaken, not stirred: Berkeley lab scientists spy molecular maneuvers
8. Using new technique, scientists uncover a delicate magnetic balance for superconductivity
9. Scientists create computing building blocks from bacteria and DNA
10. Scientists determine alternative insecticide dramatically reduces malaria transmission
11. Scientists take up golf to prove long-standing theory of cell stickiness
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... Research and Markets has ... Diagnostics Market (Product types, Application, Technology, End User ... Profiles, Demand, Insights, Analysis, Research, Report, Opportunities, Segmentation ... their offering. This new report ... users and Geography) Global Size, Industry Analysis, Trends, ...
(Date:10/22/2014)... (PRWEB) October 21, 2014 The ... the inorganic refrigerants market in Americas with analysis ... TOC of the Americas Inorganic Refrigerants Market report, ... provided. This also provides a glimpse of the ... is supported by various tables and figures. ...
(Date:10/22/2014)... 2014 Shimadzu Scientific Instruments introduces its ... for the pain management and clinical markets. The software ... review by allowing users to highlight and review results ... QuantAnalytics allows analysts to filter results by group or ... by eliminating the need to sift through analytes of ...
(Date:10/22/2014)... WriteResult, LLC – a premier ... working with a team of researchers from Yale University’s ... Farming Collaborative to provide electronic questionnaire data collection through ... which started in May, aims to evaluate the impact ... exposure to and participation in urban agriculture to impact ...
Breaking Biology Technology:Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 2Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 3The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 2The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 3Shimadzu Releases QuantAnalytics Open Access LCMS Software Package for Clinical Applications 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3
... INDIANAPOLIS, April 21 Eli Lilly and ... for the first quarter of,2008., Financial results ... pro forma,basis. Reported results were prepared in accordance ... sales and expenses recognized,by the company during the ...
... for Bacterial,Detection, The Finnish biotechnology company Mobidiag ... world record by being able to detect,50 dangerous ... is an important milestone in the battle against ... 21 Sepsis is a growing cause of ...
... for vaccinating against a variety of infectious diseases ... than needles has proved able to produce a ... new studies. , The results build on previous success ... influenza, reported by University of Michigan researchers in 2003. ...
Cached Biology Technology:Lilly Reports Solid First-Quarter Results 2Lilly Reports Solid First-Quarter Results 3Lilly Reports Solid First-Quarter Results 4Lilly Reports Solid First-Quarter Results 5Lilly Reports Solid First-Quarter Results 6Lilly Reports Solid First-Quarter Results 7Lilly Reports Solid First-Quarter Results 8Lilly Reports Solid First-Quarter Results 9Lilly Reports Solid First-Quarter Results 10Lilly Reports Solid First-Quarter Results 11Lilly Reports Solid First-Quarter Results 12Lilly Reports Solid First-Quarter Results 13Lilly Reports Solid First-Quarter Results 14Lilly Reports Solid First-Quarter Results 15Lilly Reports Solid First-Quarter Results 16Lilly Reports Solid First-Quarter Results 17/C O R R E C T I O N -- Mobidiag Ltd/ 2Nanoemulsion vaccines show increasing promise 2Nanoemulsion vaccines show increasing promise 3Nanoemulsion vaccines show increasing promise 4
(Date:10/16/2014)... Cancer constantly wages war on the human body. ... a stalemate. In pancreatic cancer, this stalemate—known as ... becoming aggressively malignant, a phenomena that is poorly ... in the laboratory of Salvatore Torquato, a Professor ... the conditions surrounding tumor dormancy and the switch ...
(Date:10/16/2014)... a new synthesis of recent research findings to inform ... the two states. , The Ecology and Management ... A Synthesis of the Relevant Biophysical Science and Implications ... by the U.S. Forest Service,s Pacific Northwest Research Station, ... for a synthesis of the large body of scientific ...
(Date:10/16/2014)... monocultures can be cultivated efficiently, they are anything ... caused by monoculture cultivation is becoming increasingly evident. ... crop form and are regarded as the sole ... – quite wrongfully, finds Bernhard Schmid, an ecology ... a novel form of agriculture and forestry. After ...
Breaking Biology News(10 mins):Modeling tumor dormancy 2New report synthesizes best available science on management of moist mixed-conifer forests 2Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3
... was launched today by the Chinese National Space Administration ... Centre, Sichuan, atop a Long March 3A rocket. ... to land robotic explorers on the Moon before 2020. ... first is to make three-dimensional images of many lunar ...
... and Ludwigshafen, Germany-October 24, 2007-Harvard University,s Office of ... agreement to jointly establish the BASF Advanced Research ... of Engineering and Applied Sciences (SEAS) the initiative ... and schools throughout the University. Set up ...
... Researchers at the University of Minnesotas Stem Cell Institute ... used to study how human embryonic stem cells differentiate. ... Experimental Biology and Medicine. Researchers know very little ... fully understand these cells self renewal capacity and pluripotency, ...
Cached Biology News:Chang'e-1 -- new mission to Moon lifts off 2BASF and Harvard University announce extensive research collaboration 2
Mouse polyclonal antibody raised against a partial recombinant MHC2TA. NCBI Entrez Gene ID = 4261...
... Sight DS-L2 imaging controller is a successor ... and allows users to comfortably observe, record ... controller features an 8.4 inch LCD (XGA) ... of Nikon cameras including the DS-Fi1 , ...
Mouse monoclonal antibody to ST8SIA2 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2...
... Parametric Analyzer and Sorter) large particle flow ... of flow cytometry to applications that were ... analysis and sorting. Our instruments are ... flow cytometers, but are designed to accommodate ...
Biology Products: