Navigation Links
Sensitivity Enhancements to Monogram's Trofile(TM) Assay Demonstrate Improved Power to Select Patients for CCR5 Antagonist Therapy
Date:6/16/2008

SOUTH SAN FRANCISCO, Calif., June 16 /PRNewswire-FirstCall/ -- Monogram Biosciences, Inc. (Nasdaq: MGRM) today announced that data related to the enhanced performance of the company's HIV tropism assay were presented in an oral presentation at the 17th International HIV Drug Resistance Workshop in Sitges, Spain. Trofile was introduced commercially upon FDA approval of Selzentry(TM) (maraviroc), Pfizer's first in class CCR5 antagonist, in August 2007. Recent enhancements to Monogram's Trofile(TM) HIV co-receptor tropism assay have made it substantially more sensitive at identifying minor subpopulations of CXCR4-using virus (X4 or dual/mixed (D/M) tropic) that may portend treatment failure with CCR5 antagonists. The Trofile assay is now capable of detecting CXCR4 tropic virus existing at levels as low as, or in some cases lower than, 0.3% of the total virus population. At levels of X4 using virus as low as 0.3%, Trofile is 100% sensitive.

"The CCR5 antagonist class of drugs has become an important addition to the choice of therapies for treatment of HIV," said Eric Daar, M.D., Chief of HIV Medicine at Harbor-UCLA Medical Center. "Selecting the right patients is critical, not just for the appropriate use of CCR5 antagonists but also to protect the other drugs in the patient's regimen from unnecessary exposure to the development of resistance. The availability of Trofile with enhanced sensitivity now provides further confidence for physicians that treatment choices can be properly assessed."

In an oral presentation during the session on "New Resistance Technologies and Interpretations," Monogram scientist Dr. Jacqueline Reeves presented an analysis of subjects from the AIDS Clinical Trials Group 5211 (ACTG 5211) study. ACTG 5211
'/>"/>

SOURCE Monogram Biosciences, Inc.
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. Agendia Acquires Rights to the Discovery of a Major Drug Resistance Mechanism in Breast Cancer Potentially Leading to a Herceptin(R) Sensitivity Test
2. ANX-514 Reduces Hypersensitivity Reactions Without Impacting Pharmacokinetics or Antitumor Activity in Preclinical Tests
3. Data Presented on Monogram HIV Tropism Tests at Retrovirus Conference sets New Standards of Assay Sensitivity
4. New Dual Cold Probe From Varian, Inc. Increases Sensitivity and Reduces Analysis Times for 13C NMR Experiments
5. Olympus FluoroPoint(TM) System Provides High-Sensitivity Single Molecule and Protein Interaction Analysis for Screening and Research
6. Study Reaffirms Superiority of Trofile(TM) Assay
7. New York Medicaid Program Establishes Coverage for Trofile(TM)
8. Caliper Life Sciences Introduces High Throughput RNA Assay to Improve Workflow in Gene Expression Studies
9. ProImmune Launches New MHC-Peptide Binding Assay for Class II HLA Alleles
10. Assay Designs(TM) Announces Additions to the Leadership Team
11. MedAssets Supply Chain Systems Selects Siemens Medical Solutions Diagnostics for Chemistry, Automation and Immunoassay Solutions
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... 22, 2014  The Broad Institute today announced ... Ted Stanley aimed at galvanizing scientific ... based on molecular understanding to hundreds of millions ... The Stanley commitment – the largest ever in ... research in general – will support research by ...
(Date:7/22/2014)... , 22. Juli 2014 Qforma, ein ... die Ernennung von Marcus Bergler zum General Manager ... hat die europäischen kommerziellen Aktivitäten von Qforma bereits ... sich Qforma anschloss, war er in Positionen als ... als Vertriebsteam-Leiter Deutschland bei IMS Health und als ...
(Date:7/21/2014)... Lawrence Livermore National Laboratory ... Las Positas College (LPC) recently established a 24-month ... training for veterans, officials recently announced. , The ... is designed to help veterans develop the ... and establishes a pipeline of qualified candidates for ...
(Date:7/21/2014)... EUGENE, Ore. (July 21, 2014) The yield ... of Oregon have developed a low-energy, solution-based mineral substitution ... that could find use in electronics and alternative energy ... on the cover of the July 21 issue of ... most citations of research in the inorganic and nuclear ...
Breaking Biology Technology:$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 2$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 3$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 4$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 5$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 6$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 7$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 8$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 9$650 million commitment to Stanley Center at Broad Institute aims to galvanize mental illness research 10Qforma gibt Schaffung des neuen Postens als General Manager in Europa bekannt 2Engineering Program Established for Veterans 2Engineering Program Established for Veterans 3Oregon chemists eye improved thin films with metal substitution 2
... Mass., March 17 The pro bono healthcare ... ), has announced that its newly instituted Safe ... Lutheran Health System of La Crosse, Wisconsin. The ... outstanding accomplishments in safe patient handling, safe lifting, ...
... Pharmaceuticals Inc., a specialty pharmaceutical company, announces the ... Vice President of the Ferring International PharmaScience Center ... Pharmaceuticals Inc. Dr. Korner was formerly Vice ... and Gastroenterology therapeutic areas, as well as Product ...
... 19, 2009 at 11:00 AM ET LIVINGSTON, N.J., ... Inc. (OTC Bulletin Board: MLSS), the recognized leader in ... file its 2008 year-end results for the 12 months ... Exchange Commission on Tuesday, March 17, 2009. Having ...
Cached Biology Technology:Gundersen Lutheran Health System is Recognized for Safe Lifting Leadership 2Gundersen Lutheran Health System is Recognized for Safe Lifting Leadership 3Dr. Paul Korner Promoted to Senior Vice President of Ferring International PharmaScience Center U.S. 2Milestone Scientific to Report 2008 Year-End Results on Tuesday, March 17, 2009 2Milestone Scientific to Report 2008 Year-End Results on Tuesday, March 17, 2009 3
(Date:7/22/2014)... most kids will hear that drinking milk helps make their bones ... these messages foster the idea that if something is good for ... in the Journal of Consumer Research , when children hear ... it. , "We predicted that when food is presented to children ... goal such as learning how to read or count, they would ...
(Date:7/22/2014)... MSN, APRN, PMHCNS-BC, CNE, Assistant Professor of Clinical ... School of Nursing, contributed samples used in a ... with schizophrenia and also suggesting a possible link ... Biological insights from 108 schizophrenia-associated genetic loci, was ... , available at http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13595.html., ...
(Date:7/22/2014)... side of meerkats which sees them prevent their daughters ... a new study. , Research into the desert creatures ... many adult helpers shows that the alpha female can ... The study shows how this way of life, also found ... effective despite its sinister side. , Dominant meerkats control ...
Breaking Biology News(10 mins):LSUHSC contributes to work identifying new DNA regions associated with schizophrenia 2
... Many of society,s most challenging health issues, including obesity, ... University of Missouri researchers are examining the multiple facets ... from medicine and research to policy and law to ... in the Mizzou Advantage (During a three-year process, MU ...
... of the Key West, Fla., population over 1,000 people ... 2009, according to a report from the Centers for Disease ... After three initial locally acquired cases of dengue were ... Department of Health conducted a study to estimate the potential ...
... Detecting oral cancer in its earliest stages can save ... early detection has been difficult. Case Western Reserve ... human beta defensin-3 (hBD-3), which may serve as an early ... and associated with the early stages of oral cancer. ...
Cached Biology News:Food for our future -- it's more than what's for dinner 2Food for our future -- it's more than what's for dinner 3Report suggests nearly 5 percent exposed to dengue virus in Key West 2CWRU dental researchers discover human beta defensins-3 ignite in oral cancer growth 2