Navigation Links
See-through organs and bodies will accelerate biomedical discoveries
Date:7/31/2014

The ability to see through organs and even the entire body to visualize long-range connections between cells as well as fine-grained cellular structures has been a long-time dream of biologists. A study published by Cell Press July 31st in the journal Cell has now made that dream a reality, revealing simple methods for making opaque organs, bodies, and human tissue biopsies transparent, while keeping the cellular structures and connections intact. The protocols could pave the way for a better understanding of brain-body interactions, more accurate clinical diagnoses and disease monitoring, and a new generation of therapies for conditions ranging from autism to chronic pain.

"Although the idea of tissue clearing has been around for a century, to our knowledge, this is the first study to perform whole-body clearing, as opposed to first extracting and then clearing organs outside the adult body," says senior study author Viviana Gradinaru of the California Institute of Technology. "Our methodology has the potential to accelerate any scientific endeavor that would benefit from whole-organism mapping, including the study of how peripheral nerves and organs can profoundly affect cognition and mental processing, and vice versa."

Three-dimensional maps of intact organs and bodies are crucial for understanding complex, long-distance cellular interactions that play an important role in a range of biological processes. But until now, methods for making whole organs or bodies transparent and thus amenable to imaging and generating 3D maps have been limited to the brain or embryos. Gradinaru and her collaborators previously developed a brain-clearing technique called CLARITY, which involves embedding tissue into hydrogels to preserve its 3D structure and important molecular features, and then using detergents to extract lipids that make the tissue opaque.

In the new study, the researchers set out to make CLARITY suitable for whole o
'/>"/>

Contact: Mary Beth O'Leary
moleary@cell.com
617-397-2802
Cell Press
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. Dr. Rongxiang Xu to Reveal How Human Organs can Achieve Self-Regeneration during His Acceptance of the International Golden Biatec 2013 Award
2. Damaged Tissues and Organs Could be Repaired With New Scaffolding Technique
3. Dr. Rongxiang Xu, Owner of Patented Technology to Regenerate Damaged Organs, Announces Lawsuit Against 2012 Nobel Laureate Dr. Shinya Yamanaka
4. Findings could be used to engineer organs
5. Engineered anti-toxin antibodies improve efficacy
6. Monoclonal Antibodies Market in Colorectal Cancer to 2019
7. Industry Shares, Size, Trend, Analysis, and Forecasts Report Available Online by Researchmoz.us
8. The Engineered T-Cell Receptor in Fusion Proteins, Antibodies & Cells: Emerging Opportunities for the Biopharmaceutical Industry
9. NKT Therapeutics Identifies Novel anti-iNKT Antibodies for Depleting or Activating iNKT Cells
10. Monoclonal Antibodies Market in Breast Cancer to 2019
11. Identifying targets of autoantibodies
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
See-through organs and bodies will accelerate biomedical discoveries
(Date:7/1/2015)...   Decision Resources Group finds that ... are its oral administration, alternative mechanism of action, ... rheumatologists. Otezla was the first oral therapy specifically ... psoriatic arthritis in the United States ... conventional oral treatments including disease-modifying antirheumatic drugs (DMARDs), ...
(Date:7/1/2015)... July 1, 2015   Neuraltus Pharmaceuticals, Inc. ... of groundbreaking drugs to treat neurodegenerative diseases such ... Robert G. Miller , M.D., Director of the ... California Pacific Medical Center in San Francisco, has been ... $1.5 million to help fund a Phase 2 ...
(Date:7/1/2015)... ... July 01, 2015 , ... A newly launched business plan ... lower the barriers to innovation in life sciences R&D. The Pistoia Alliance President’s Startup ... prizes of US$15,000 and a period of expert mentorship from a senior industry figure ...
(Date:7/1/2015)... ... July 01, 2015 , ... ... pathogen transmission. CTI’ new Medical Joysticks have an impermeable molecular barrier protection ... an operator control device that will increase healthcare worker safety and reduce financial ...
Breaking Biology Technology:Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 2Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4Pistoia Alliance Launches Startup Challenge 2Pistoia Alliance Launches Startup Challenge 3Sanitized Medical Joysticks for a Safer and Healthier Work Environment 2
... Brinks Hofer Gilson & Lione, one of,the largest ... to announce that Meredith Martin Addy has been named ... practice areas by Law & Politics,magazine., Intellectual property ... However, in fourteen years of practice, Ms. Addy is,among ...
... ST. LOUIS, Feb. 19 Sigma-Aldrich(R) (Nasdaq:,SIAL) is ... joined,Sigma-Aldrich as Vice President of Global Marketing for ... responsible for our strategic,and commercial marketing efforts to ... launch of innovative products into the life,science market. ...
... 19 Campbell Alliance, the leading,management consulting ... today announced that executives from its Brand ... the 4th Annual Forum on Early,Stage Product ... hosted by the Center for Business Intelligence,(CBI). ...
Cached Biology Technology:Meredith Martin Addy Named One of Top 10 Illinois 'Super Lawyers' for 2008 2Sigma-Aldrich Names Helge Bastian New VP of Global Marketing for Research Biotech 2Campbell Alliance Brand Management and Managed Markets Practices to Speak at CBI's Early Commercialization Conference 2Campbell Alliance Brand Management and Managed Markets Practices to Speak at CBI's Early Commercialization Conference 3Campbell Alliance Brand Management and Managed Markets Practices to Speak at CBI's Early Commercialization Conference 4
(Date:6/24/2015)... , June 24, 2015 The biologics safety ... major drivers for the market include growth of the ... new drug launches. Over the years, the number of ... 2001 and 2010, the FDA approved 225 drug applications ... WIPO, Europe accounted for 3,822 ...
(Date:6/23/2015)... , June 23, 2015   MedNet ... that supports the entire spectrum of clinical research, ... ™ , the company,s intuitive, flexible ... awarded a Silver 2015 Stevie® Award by the ... Products & Services Website category.  The American Business ...
(Date:6/18/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company") ... market announces that its Wocket® smart wallet will be the ... scheduled to air on WABC Radio (am770) in ... The broadcast air- time for the extensive one ... Inc.,s CEO Gino Pereira will be discussing its ...
Breaking Biology News(10 mins):Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4MedNet Solutions' iMedNet eClinical Wins Silver Stevie Award 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3
... use of a robot to assist with the most ... patient,s risk of developing a rare but serious complication, ... edition of the Journal of Robotic Surgery. ... School at Houston statistically analyzed operative times, length of ...
... geneticist at The University of Texas Health Science Center at ... in the hopes of finding out why blood pressure often ... principal investigator Myriam Fornage, Ph.D., is funded with a new ... (GEI) of the National Institutes of Health. The grant was ...
... HOUSTON (Sept. 24, 2008) Self-guided treatment ... click away. Scientists with the National ... interactive, multi-media program that will assist astronauts in ... problems, which can pose a substantial threat to ...
Cached Biology News:Robotic surgery lowers risk of a rare but serious complication of gastric bypass 2Scientist plans to test for blood pressure genes affected by age 2Coming soon: Self-guided, computer-based depression treatment 2Coming soon: Self-guided, computer-based depression treatment 3
Mouse monoclonal antibody raised against a partial recombinant PUM2. NCBI Entrez Gene ID = PUM2...
... The pWEB::TNC™ Deletion Cosmid Cloning Kit ... days, a complete and unbiased primary cosmid ... in making nested deletion sublibraries. High efficiency ... and highly reproducible kit protocols. First, genomic ...
... optically clear polystyrene with frosted labeling ... for cell counting. 100% integrity tested. ... new product number, created to easily ... no availability yet, please order under ...
Mouse monoclonal antibody raised against a partial recombinant AATK. NCBI Entrez Gene ID = AATK...
Biology Products: