Studies utilizing XF technology are revealing the metabolic dependencies of cancer cells on glucose or other substrates, such as glutamine and fatty acids. With this knowledge scientists are now able to determine cancer cell substrate preferences, and establish potential pathways to target for intervention.
"The XF Analyzer is unique technology that has provided us with an incredible platform for measuring the changes in cellular oxygen consumption, and extracellular acidification, in real-time. The XF24 Analyzer has helped us to identify small, novel molecules that are able to exert anti-cancer effects by modulating bioenergetics and redox state," said Divya Pathania , Ph.D., from the University of Southern California, in Los Angeles, CA.
"We've been investigating the bioenergetic response during adaptation to low oxygen tension by highly metastatic breast cancer cells. The XF Analyzer was the technology that enabled us to measure these responses, under hypoxic conditions, in real-time. This knowledge is now leading us to the discovery of a novel biphasic bioenergetic behavior by cancer cells, which may be useful as a target for cancer therapy," stated Praveen Vayalil , Ph.D., from the University of Alabama at Birmingham, Birmingham, AL.
About Seahorse Bioscience
Seahorse Bioscience XFe Analyzers and stress test kits are the industry standard in cell metabolism measurements. Scientists worldwide are advancing their research in understanding the role of bioenergetics in Neurodegeneration, Aging, Cancer, Card
|SOURCE Seahorse Bioscience|
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