Seahorse travel awards are offered to graduate students, post-doctoral researchers, and young investigators who present a talk or poster citing data generated on the XF platform at scientific meetings and conferences. Through this program, Seahorse seeks to increase the body of knowledge that is enabling new discoveries about the role of cell metabolism in pathophysiology, and in particular cancer.
"One focus of our lab's research is to therapeutically target the acidic microenvironment of solid tumors using buffers, which we have shown reduces metastasis in many tumor types. Seahorse XF technology allowed us to classify buffer sensitive and resistant tumor types, based on their metabolic phenotypes. A greater understanding of tumor metabolism has proven essential to effectively target the tumor microenvironment in pre-clinical and clinical settings," stated Kate Bailey , Ph.D., from the H. Lee Moffitt Cancer Center in Tampa, FL.
The Seahorse XFe Extracellular Flux Analyzer and stress test kits standardize the measurement of mitochondrial function and cancer metabolism, in real-time, in a microplate. In minutes, the XFe Analyzer measures the oxygen consumption rate (OCR) -- a measure of mitochondrial respiration -- and the extracellular acidification rate (ECAR) -- a measure of glycolysis -- to providing the most physiologically relevant in vitro measurement of cancer metabolism available today.
"The composition and characteristics of the tumor microenvironment vary widely and are important in determining the anti-tumor immune response. In our lab we assess how an abnormal tumor microenvironment affects T-cell activation and tumor targeting function in a prostate cancer model. We used the XF Analyzer to characterize cellular bioenergetics in prostate cancer cells. A greater understanding of how the metabolic proce
|SOURCE Seahorse Bioscience|
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