Navigation Links
Scientists identify mammal model of bladder regeneration

WINSTON-SALEM, N.C. While it is well known that starfish, zebrafish and salamanders can re-grow damaged limbs, scientists understand very little about the regenerative capabilities of mammals. Now, researchers at Wake Forest Baptist Medical Center's Institute for Regenerative Medicine report on the regenerative process that enables rats to re-grow their bladders within eight weeks.

In PLOS ONE, a peer-reviewed, online publication, the scientists characterize this unique model of bladder regeneration with the goal of applying what they learn to human patients.

"A better understanding of the regenerative process at the molecular and cellular level is a key to more rapid progress in applying regenerative medicine to help patients," said George Christ, Ph.D., senior researcher and professor of regenerative medicine at Wake Forest Baptist.

In a previous study by Christ's team, research in rats showed that when about 75 percent of the animals' bladders were removed, they were able to regenerate a complete functional bladder within eight weeks. The current study focused on how the regeneration occurs.

"There is very little data on the mechanisms involved in organ regeneration in mammals," said Christ. "To our knowledge, bladder regeneration holds a unique position there is no other mammalian organ capable of this type of regeneration."

The ability of the liver to grow in size when lobes are removed is sometimes referred to as regeneration, but this is a misnomer, said co-author Bryon Petersen, Ph.D., who was a professor of regenerative medicine at Wake Forest Baptist during the period the research occurred. Instead, through a proliferation of cells, the remaining tissue grows to compensate for the lost size. In contrast, the hallmark of true regeneration is following nature's "pattern" to exactly duplicate size, form and function, Petersen said.

"If we can understand the bladder's regenerative process, the hope is that we can prompt the regeneration of other organs and tissues where structure is important from the intestine and spinal cord to the heart," said Petersen.

The current study showed that the animals' bodies responded to the bladder removal by increasing the rate at which certain cells divided and grew. The most notable proliferative response occurred initially in the urothelium, the layer of tissue that lines the bladder.

As the proliferative activity in the bladder lining waned, it continued elsewhere: in the fibrous band (lamina propria) that separates the bladder lining from the bladder muscles and in the bladder muscle itself.

The researchers have several theories about how the process works, said Christ. One possibility is that cells in the bladder lining transition and become a type of stem cell that can proliferate throughout the bladder. Other theories are that cells in the bladder lining signal other cells to replicate and that injury prompts stem cells to arrive through the blood stream to repair the bladder damage.

In future studies, the scientists will work to identify the exact regenerative process and will expand the work into mice. The ability to breed mice that lack specific genes will enable the team to explore how genes and proteins may affect the regenerative process and possibly help identify therapies to prompt regeneration.

Contact: Karen Richardson
Wake Forest Baptist Medical Center

Related biology technology :

1. Scientists build mechanically active DNA material
2. GenScript to Synthesize Yeast Genome with Johns Hopkins Scientists
3. Scientists report successful vaccine developed against deadly Nipah virus
4. Worlds smallest semiconductor laser created by University of Texas scientists
5. Scientists read monkeys inner thoughts
6. World record: Scientists from northern Germany produce the lightest material in the world
7. NineSigma Partners with Scientists Without Borders to Find New Sustainable Packaging for Micronutrient Powders that Combat Malnutrition
8. Scripps Research Institute scientists find easier way to make new drug compounds
9. Finding Brings Scientists One Step Closer To Parkinsons Drug
10. Stanford scientists spark new interest in the century-old Edison battery
11. Scientists gain understanding of self-cleaning gecko foot hair
Post Your Comments:
(Date:6/27/2016)... CLEVELAND , June 27, 2016  Global ... average 4.6 percent through 2020 to $7.2 billion.  ... (food and beverages, cleaning products, biofuel production, animal ... and biotechnology, diagnostics, and biocatalysts). Food and beverages ... gains driven by increasing consumption of products containing ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... innovative medical technologies, services and solutions to the healthcare market. The company's primary ... various distribution, manufacturing, sales and marketing strategies that are necessary to help companies ...
(Date:6/24/2016)... Epic Sciences unveiled a liquid biopsy ... PARP inhibitors by targeting homologous recombination deficiency (HRD) ... test has already been incorporated into numerous clinical ... Over 230 clinical trials are investigating ... PARP, ATM, ATR, DNA-PK and WEE-1. Drugs targeting ...
(Date:6/23/2016)... , June 23, 2016   Boston ... of novel compounds designed to target cancer stemness ... has been granted Orphan Drug Designation from the ... treatment of gastric cancer, including gastroesophageal junction (GEJ) ... inhibitor designed to inhibit cancer stemness pathways by ...
Breaking Biology Technology:
(Date:6/20/2016)... , June 20, 2016 Securus Technologies, ... technology solutions for public safety, investigation, corrections and ... prisons involved, it has secured the final acceptance ... facilities for Managed Access Systems (MAS) installed. Furthermore, ... facilities to be installed by October, 2016. MAS ...
(Date:6/9/2016)... June 9, 2016 Paris ... Teleste,s video security solution to ensure the safety of people ... during the major tournament Teleste, an international ... and services, announced today that its video security solution will ... to back up public safety across the country. The system ...
(Date:6/2/2016)... 2, 2016   The Weather Company , an IBM ... an industry-first capability in which consumers will be able to ... ask questions via voice or text and receive relevant information ... Marketers have long sought an advertising solution that ... be personal, relevant and valuable; and can scale across millions ...
Breaking Biology News(10 mins):