Navigation Links
Scientists discover how cancer may take hold
Date:9/24/2007

Stanford, CA-- A team, led by researchers at the Carnegie Institution,* has found a key biochemical cycle that suppresses the immune response, thereby allowing cancer cells to multiply unabated. The research shows how the biomolecules responsible for healthy T-cells, the bodys first defenders against hostile invaders, are quashed, permitting the invading cancer to spread. The same cycle could also be involved in autoimmune diseases such as multiple sclerosis. The work is published in the September 25, 2007, issue of PLoS Biology.

The scientists used special molecular nanosensors for the work. We used a technique called fluorescence resonance energy transfer, or FRET, to monitor the levels of, tryptophan, one of the essential amino acids human cells need for viability, explained lead author Thijs Kaper. Humans get tryptophan from foods such as grains, legumes, fruits, and meat. Tryptophan is essential for normal growth and development in children and nitrogen balance in adults. T-cells also depend on it for their immune response after invading cells have been recognized. If they dont get enough tryptophan, the T-cells die and the invaders remain undetected.

The scientists looked at the chemical transformations that tryptophan undergoes as it is processed in live human cancer cells. When tryptophan is broken down in the cancer cells, an enzyme (dubbed IDO) forms molecules called kynurenines. This reduces the concentration of tryptophan in the local tissues and starves T-cells for tryptophan. A key finding of the research was that a transporter protein (LAT1), present in certain types of cancer cells, exchanges tryptophan from the outside of the cell with kynurenine inside the cell, resulting in an excess of kynurenine in the body fluids, which is toxic to T-cells.

Its double trouble for T-cells, remarked Wolf Frommer. Not only do they starve from lack of tryptophan in their surroundings, but it is replaced by the toxic kynurenines, w
'/>"/>

Contact: Wolf Frommer
wfrommer@stanford.edu
650-325-1521 x208
Carnegie Institution
Source:Eurekalert

Page: 1 2

Related biology technology :

1. UW computer scientists fighting computer virus "Cold War"
2. Scientists find way to make human collagen in lab
3. Wisconsin scientists to be recognized for innovative biofuel technology
4. UW-Madison scientists to mimic nature for newest cancer drugs
5. UW scientists study strange material with communications potential
6. Scientists find nanotech method for examining cells
7. UW space scientists use Keck telescope to study wild weather of Uranus
8. UW computer scientists tout achievements and explain industry shortcomings
9. Facing shortage of U.S. scientists, UW wants to boost math enrollment
10. UW-Madison scientists find a key to cell division
11. TIP/UW Scientists Provide Mars Rover Commentary
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2015)... 26, 2015 Innovacyn, a leader ... the human and animal health industries, announced today ... Innovators of Agriculture College Scholarship Award. The scholarship ... exhibits a passionate commitment to the agriculture industry ... year’s winners, Alexis Pedrow from Anderson County Jr/Sr ...
(Date:5/26/2015)... and HILDEN, Germany , May ... (NASDAQ: QGEN ; Frankfurt Prime Standard: QIA) ... Clinical Insight ® (QCI™) bioinformatics content and ... and report on genomic variants identified in next-generation ... the bioinformatics platform are in oncology, for somatic ...
(Date:5/26/2015)... Intrexon Corporation (NYSE: XON ), a leader in ... Senior Vice President and Head of Intrexon,s Health Sector, will ... June 3 rd , at 1:30 p.m. Eastern Time at ... . About Intrexon Corporation Intrexon Corporation ... Better DNA ™ to create biologically-based products that improve ...
(Date:5/26/2015)... Tianyin Pharmaceutical Inc. (NYSE Amex: TPI ... biopharmaceutical, modernized traditional Chinese medicine (mTCM), branded generics and ... Meeting of Shareholders for fiscal year ended June 30, ... Company,s office located in Chengdu, China ... time in Chengdu, China ) on ...
Breaking Biology Technology:Innovacyn Announces Winners Of This Year’s Vetericyn® College Scholarship Award 2Innovacyn Announces Winners Of This Year’s Vetericyn® College Scholarship Award 3QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 2QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 3QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 4QIAGEN Launches Clinical Bioinformatics Platform for Next-Generation Sequencing 5Intrexon to Present at the Jefferies 2015 Global Healthcare Conference 2TPI Adjourned Its 2014 Annual Shareholder Meeting and Received Notice of Non-Compliance with NYSE MKT Continued Listing Requirements 2TPI Adjourned Its 2014 Annual Shareholder Meeting and Received Notice of Non-Compliance with NYSE MKT Continued Listing Requirements 3
... Corporation, a leading orthopaedic biomaterials company, announced today ... of Beta-bsm(TM) Injectable Paste and Gamma-bsm(TM) Moldable Putty ... Both products are bone substitute materials based on ... http://www.newscom.com/cgi-bin/prnh/20080424/NETH117LOGO ...
... 27 Spherix Incorporated (Nasdaq: SPEX ), ... provider of technical and regulatory consulting services to food, ... April 23, 2009, it received written notification from NASDAQ ... NASDAQ,s independent director rule. Spherix fell out of ...
... VOLC ), a leader in the development, manufacturing and ... and peripheral artery disease, today announced that it will report ... on Tuesday, May 5.The company will hold a conference call ... all interested parties at 2 p.m., Pacific Daylight Time (5 ...
Cached Biology Technology:ETEX Corporation Announces FDA Clearance of Small Size Beta-bsm(TM) Injectable Paste and Gamma-bsm(TM) Moldable Putty 2Spherix Recruiting New 'Independent' Director to Regain NASDAQ Compliance 2Spherix Recruiting New 'Independent' Director to Regain NASDAQ Compliance 3Volcano Corporation Schedules First Quarter Conference Call, Webcast 2
(Date:5/6/2015)... 2015 LifeBEAM, a developer of bio-sensing technology, ... today that they will expand their partnership in bio-sensing ... cycling helmet and the first joint project between the ... in order to give cyclists more style choices and ... and Lazer announced their plan to release a new ...
(Date:4/27/2015)... 27, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market, announces that ... customers the first week of May, 2015 and will ... May. Gino Pereira , Chief ... the company as Wocket® enters the consumer market. We ...
(Date:4/20/2015)... April 20, 2015 Huntington Memorial Hospital is ... implant a new miniaturized, wireless monitoring sensor to manage ... first and only FDA-approved heart failure monitoring device that ... used by physicians to manage heart failure. ... implanted in the pulmonary artery (PA) during a non-surgical ...
Breaking Biology News(10 mins):LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3
... , SAN FRANCISCO, CANovember 11, 2013What does it mean ... ultimately, in the billions of lines of genetic code ... been deciphering that code. But now, researchers at the ... stretches of DNA control the development of uniquely human ...
... led by bioengineers at the University of California, San Diego ... E. coli cells and individual neurons from the human ... technique that confines genome amplification to fluid-filled wells with a ... published in the journal Nature Biotechnology on November ...
... at the University of California, San Diego School of Medicine ... to govern regulated gene expression. The study was published on ... Nature Structural and Molecular Biology . "We uncovered ... RNA-binding proteins to induce a regulatory effect from ...
Cached Biology News:Fast-mutating DNA sequences shape early development; guided evolution of uniquely human traits 2Fast-mutating DNA sequences shape early development; guided evolution of uniquely human traits 3Single-cell genome sequencing gets better 2Single-cell genome sequencing gets better 3Un-junking junk DNA 2Un-junking junk DNA 3
Anti-Dynamin Monoclonal Antibody Description: 100 g Research Focus: neuroscience Storage: -20C Shipping Temperature: 4C...
cysteine and glycine-rich protein 2,...
BKBeta2 potassium channel Antigen: Fusion protein amino acids 1-41 (N-terminus) and 218-235 (C-terminus) of mouse BKBeta2 Accession Number: Q9CZM9...
Anti-CD74 Monoclonal Antibody Description: 200 l Research Focus: cell surface antigens Storage: 4C Shipping Temperature: 4C...
Biology Products: