Navigation Links
Scientists develop way to successfully give nanoparticle therapeutics orally
Date:11/27/2013

Boston, MA Pop a pill or be poked by a needle? Being able to orally deliver microscopic particlesknow as nanoparticlesloaded with medicine is a simple, convenient way to treat patients for various diseases, such as cancer or diabetes. But so far, nanoparticles can only be given via injection since they have trouble being readily absorbed by the intestine, which limits their usefulness.

Now a study led by researchers at Brigham and Women's Hospital (BWH) and Massachusetts Institute of Technology (MIT) is the first to report in the field of nanomedicine a new type of nanoparticle that can be successfully absorbed through the digestive tract. The findings may one day allow patients to simply take a pill instead of receiving injections.

The study will be published online November 27, 2013 in Science Translational Medicine.

The nanoparticles developed by the researchers are decorated with antibodies that attach to receptors found on the cell surfaces that line the intestines. Once attached, the nanoparticles gain entry past the cellular barriers in intestinal walls and into the bloodstream. According to the researchers, this type of drug delivery could also be useful in developing new treatments for conditions such as high cholesterol or arthritis.

"The novelty of actively being able to transport targeted nanoparticles across cell barriers can potentially open up a whole new set of opportunities in nanomedicine," said Omid Farokhzad, MD, director of the BWH Laboratory of Nanomedicine and Biomaterials, senior study author. "The body has receptors that are involved in shuttling proteins across barriers, as is the case in the placenta between the mother and fetus, or in the intestine, or between the blood and the brain. By hitching a ride from these transporters the nanoparticles can enter various impermeable tissues."

Until recently, after being injected into the body, nanoparticles travelled to their destination
'/>"/>

Contact: Marjorie Montemayor-Quellenberg
mmontemayor-quellenberg@partners.org
617-525-6383
Brigham and Women's Hospital
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Scientists defuse the Vietnam time bomb
2. Singapore scientists lead human embryonic stem cell study
3. Sheffield scientists shine a light on the detection of bacterial infection
4. Nanowiggles: Scientists discover graphene nanomaterials with tunable functionality in electronics
5. Scientists solve mystery of colorful armchair nanotubes
6. iBioSeminars and iBioMagazine: Free, Online Biology Seminars and Short Talks by Leading Scientists
7. Chinese Scientists Zhen-Yi Wang and Zhu Chen Awarded 7th Annual Szent-Gyorgyi Prize for Progress in Cancer Research
8. Scientists decode brain waves to eavesdrop on what we hear
9. Receptos Scientists Publish Determination of a High Resolution Sphingosine 1-Phosphate Receptor 1 Structure in Science
10. Scientists learn how to out run damage with imaging technique
11. Design eye for the science guy: Drop-in clinic helps scientists communicate data
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/26/2014)... 2014 In keeping with the holiday ... bevy of last-minute Thanksgiving savings. The company is offering ... all product lines this holiday weekend as well as ... Friday, and Cyber Monday are right around the corner, ... both loyal customers and those looking to explore their ...
(Date:11/26/2014)... , Nov. 26, 2014 The ... from a survey of European physicians at the ... Innovation and Biological Therapies" at the Spanish Ministry ... hosted by EuropaBio and the Spanish Bioindustry Association ... Health, physicians from Spanish oncology and rheumatology societies, ...
(Date:11/26/2014)... 2014 PMG Research, Inc. announced ... is a network of sites that provide clinical research services ... million patient lives through its partnerships with large physician practices ... hub site locations in the Southeastern United States and spans ... the board will be held by: Dr. Robert ...
(Date:11/26/2014)... Silicon Valley Electronic Data Capture (EDC) ... Alliance , provider of clinical research and data management ... addition to its CRO Partnership Program, Clinovo expands ... India. , “We have found Clinovo’s ClinCapture to ... platform which is both user friendly and easy to ...
Breaking Biology Technology:DNA Spectrum Offers Last Minute Thanksgiving Coupons 2DNA Spectrum Offers Last Minute Thanksgiving Coupons 3ASBM Presents European Physicians Survey at Spanish Ministry of Health 2PMG Research Names Medical Advisory Board 2PMG Research Names Medical Advisory Board 3RPM Alliance Joins Clinovo’s CRO Partnership Program, Further Strengthening Its Presence in Southern California and India 2
... cancer is able to receive stereotactic body radiotherapy (SBRT) ... 71, that due to the weakened condition of his ... his lung tumor. To treat the tumor, Arul Mahadevan, ... type of non-invasive radiosurgery using the Novalis Tx(TM) platform ...
... Cellular Bioengineering, Inc. (CBI) announces it is developing a ... medicine and other consumables, but can also be used ... parts, great works of art, currency, electronic components, high ... the Multimedia News Release go to: ...
... Va. May 26 CEL-SCI Corporation (NYSE ... is developing an immune-based treatment for the "swine flu ... (Ligand Epitope Antigen Presentation System) vaccine technology. The ... has gained from developing protective and therapeutic vaccines utilizing ...
Cached Biology Technology:Doctors in New Hampshire Now Treating Cancer with Non-Invasive Image-Guided Radiosurgery Using Novalis Tx(TM) Technology 2Doctors in New Hampshire Now Treating Cancer with Non-Invasive Image-Guided Radiosurgery Using Novalis Tx(TM) Technology 3Photos: Breakthrough Technology Enables Edible TruTag(TM) to Prevent Counterfeit Medicine 2Photos: Breakthrough Technology Enables Edible TruTag(TM) to Prevent Counterfeit Medicine 3CEL-SCI Developing Immune-Based Treatment Against Swine and Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology 2CEL-SCI Developing Immune-Based Treatment Against Swine and Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology 3CEL-SCI Developing Immune-Based Treatment Against Swine and Other H1N1 Flu Viruses Using Proprietary L.E.A.P.S. Technology 4
(Date:11/5/2014)... de Janeiro, Brazil -Individuals show great diversity in their ... males and females greatly differ in their perceptual evaluation ... of smell tests. , Sex differences in ... behaviors and may be connected to one,s perception of ... emotions. Thus, women,s olfactory superiority has been suggested to ...
(Date:11/4/2014)... newly published research study examining only marketing directed ... fast food restaurants has found that the majority ... exposed to such marketing tactics. , Authored by ... colleagues, the study is the first to examine ... and exterior of fast food restaurants and its ...
(Date:11/3/2014)... Colorado Cancer Center study published in this ... describes the activity of a recently discovered communication ... IL-37. It has been known to limit inflammation and ... immune system: IL-37 inhibits the ability of the immune ... this mechanism that underlies IL-37,s effect on the immune ...
Breaking Biology News(10 mins):The female nose always knows: Do women have more olfactory neurons? 2Fast food marketing for children disproportionately affects certain communities 2Fast food marketing for children disproportionately affects certain communities 3PNAS: From HIV to cancer, IL-37 regulates immune system 2
... developed a new vaccine that protects against lethal pneumonia ... drug-resistant strains like MRSA. The research team was ... in the UI Carver College of Medicine. The findings ... Infectious Disease . The new vaccine targets toxins ...
... December 17, 2013 , thick plumes of smoke are visible ... in the southern part of the state). They aren,t major ... near the fields say the flames have been getting too ... like an inferno. Smoke so thick it blocks the sun. ...
... presence of copper in the cells of the body. Copper ... mechanisms against oxygen radicals, as well as part of the ... formation of e.g. hormones and neurotransmitters. Imbalance in the ... for our health, as can be seen with the disorder ...
Cached Biology News:Staph stoppers 2How the cells remove copper 2How the cells remove copper 3
Recombinant Mouse Noggin...
...
Mouse Iduronate 2-Sulfatase Affinity Purified Polyclonal Ab Keywords: Sulfatases, Iduronate 2-Sulfatase, Mucopolysaccharidosis, Hunter Syndrome, Glycobiology Protein Family: Proteoglycan Regu...
Immunogen: Synthetic Peptide: C N(185) D G T E F G G S I Y Q K(197) Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biology Products: