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Scientists Find Way to Fast-Track Production of Stem Cells that Show Promise in Treating AMD
Date:4/18/2013

rect pluripotent stem cells to RPE with a similar efficiency,” Dr. Clegg explained. “Through the combined use of the retinal inducing factors IGF1, Noggin, Dkk1, bFGF and other factors added at specific times, we found that pluripotent stem cells could be directed to RPE, also with an efficiency of about 80 percent — and it only took 14 days. ”

“Protocols currently being used to generate RPE cells take months; this protocol should be useful for quickly generating quantities of RPE cells for transplantation as well as for the study of RPE development,” Dr. Buchholz added.

“This report is important because stem cell derived RPE are currently in clinical trials for the treatment of age related macular degeneration and Stargardt disease,” said Anthony Atala, M.D., Editor of STEM CELLS Translational Medicine and director of the Wake Forest Institute for Regenerative Medicine. “The protocol could prove useful for rapidly generating banks of cells for treating these conditions.”

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The full article, “Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium,” can be accessed at http://www.stemcellstm.com.

About STEM CELLS Translational Medicine: STEM CELLS TRANSLATIONAL MEDICINE (SCTM), published by AlphaMed Press, is a monthly peer-reviewed publication dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices.

About AlphaMed Press: Established in 1983, AlphaMed Press with offices in Durham, NC, San Francisco, CA, and Belfast, Northern Ireland, publishes two other internationally renowned peer-reviewed journals: STEM CELLS® (http://w
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