Navigation Links
Santaris Pharma A/S Advances RNA-Targeted Drug Development Candidate Against PCSK9, an Important New Target for the Treatment of High Cholesterol
Date:4/26/2010

HOERSHOLM, Denmark and SAN DIEGO, April 26 /PRNewswire/ -- Santaris Pharma A/S, a clinical-stage biopharmaceutical company focused on the discovery and development of RNA-targeted therapies, today announced that it has advanced into drug development a discovery research candidate directed against PCSK9 (proprotein convertase subtilisin/kexin type 9), an important new target for the treatment of high cholesterol. Using its proprietary Locked Nucleic Acid (LNA) Drug Platform and Drug Discovery Engine, Santaris Pharma A/S identified and advanced the new drug, SPC5001, in just 18 months.

High cholesterol is a major risk factor for coronary heart disease, heart attack and stroke. According to the World Health Organization, high cholesterol is estimated to cause 18% of strokes and 56% of heart disease, globally and amounts to approximately 4.4 million deaths and 40.4 million disability-adjusted life years(1).

Santaris Pharma A/S presented preclinical data on SPC5001 last month at the PCSK9 Conference "From gene to therapeutics" in Nantes, France where many top pharmaceutical companies gathered to discuss efforts to develop therapies aimed at inhibiting the important new target PCSK9, a protein involved in regulating LDL (low-density lipoprotein) or "bad" cholesterol in the blood.

Data presented by Santaris Pharma A/S scientists showed that SPC5001 provided potent, specific and long-lasting inhibition of PCSK9 and lowered mean LDL cholesterol by 50% in non-human primates with a sustained reduction of 74% in the highest responder. SPC5001 did not change HDL (high-density lipoprotein) levels or the "good" cholesterol in the blood(2). The preclinical data suggest that SPC5001 has the potential to provide patients with a new treatment opti
'/>"/>

SOURCE Santaris Pharma A/S
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. Santaris Pharma to Present at 10th Annual Biotechnology Industry Organisation CEO & Investor Conference - February 11th, 2008
2. Santaris Pharma Delivers Six LNA-Based RNA Inhibitors to Enzon Pharmaceuticals Ahead of Schedule
3. Santaris Pharma Director Appointed Adjunct Professor in RNA Biology at the University of Aalborg, Denmark
4. Santaris Pharma - Interim Report for the Period 1 January to 30 June 2009
5. Santaris Pharma A/S Forms Strategic Alliance With Shire plc to Develop RNA-Based Medicines for the Treatment of Rare Genetic Disorders
6. Shire Builds Competitive Position of its HGT Business through Research Collaboration with Santaris Pharma A/S on LNA Drug Platform
7. New Collaborations and Breakthrough Advancements in RNA-Based Drug Development Programs Lead Santaris Pharma A/S to Establish US Operations
8. Hearing Scheduled in the Delaware Court of Chancery for August 27, 2007 to Establish the Valid Approval and Consummation of the Merger Between PharmAthene, Inc. and Healthcare Acquisition Corp.
9. Pharmatek Adds Cytotoxic and High-Potent Drug Development Capabilities to San Diego Laboratory
10. Vion Pharmaceuticals Pays Interest on 7.75% Convertible Senior Notes
11. Skystar Bio-Pharmaceutical Announces Second Quarter 2007 Results
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/11/2014)... Texas , Sept. 11, 2014 XBiotech ... high throughput filling machine that the Company says will ... The fully integrated system is designed to fill, stopper ... the manufacturing process. Additionally, the unit is said to ... scanning system to provide a high level of quality ...
(Date:9/11/2014)... 11, 2014 The Registration Committee ... is now open for Pittcon 2015, the world’s ... The event will be held March 8-12, 2015, ... Louisiana. , The discounted registration fee of ... after 2/20/2015). This affordable price includes unlimited week-long ...
(Date:9/11/2014)... Francisco, California (PRWEB) September 11, 2014 ... of software and IT systems that support clinical ... Annotation™ (GVA™) Service that now supports the interpretation ... resulting in a single, user-friendly report that contains ... been used toward cancer treatment planning and support ...
(Date:9/11/2014)... 2014 /PRNewswire/ - Portage Biotech Inc. ("Portage" or "the ... that it intends to conduct a Private Placement ... funding its preclinical development activities and financial commitments ... The Company is proposing to complete a ... shares at a price of US$0.10 per Share, ...
Breaking Biology Technology:Conferee Registration Opens for Pittcon 2015; Housing & Travel Open for Reservations 2CollabRx Launches Expansion of Its Genetic Variation Annotation Service to Support Copy Number Variation (CNV) Data 2CollabRx Launches Expansion of Its Genetic Variation Annotation Service to Support Copy Number Variation (CNV) Data 3Portage Announces Proposed Private Placement 2Portage Announces Proposed Private Placement 3Portage Announces Proposed Private Placement 4
... ... Sciences Division , ... Beijing, China (PRWEB) December 9, 2009 -- China-based CSOFT International Ltd., a leading provider ... for the global market, announced today the hiring of Tammy Werner as Director of ...
... release is available in Spanish . , ... and characterized for the first time different antioxidant compounds from ... herb called Teucrium polium. They have used two new techniques, ... them to identify and quantify a great part of the ...
... , CLEVELAND, Dec. 8 ... the market with a Smart Green(TM) focus. ... packaging, Nutek,s products continue to provide safe alternatives ... (Photo: http://www.newscom.com/cgi-bin/prnh/20091208/CL22934 ) , (Logo: ...
Cached Biology Technology:CSOFT's MedL10N Hires Beckman Coulter Veteran Tammy Werner 2CSOFT's MedL10N Hires Beckman Coulter Veteran Tammy Werner 3New antioxidant compounds have been identified in foods such as olive oil, honey and nuts 2Nutek, LLC Introduces New Soy-Based, Biodegradable Lubricating and Cleaning Wipes 2
(Date:9/12/2014)... data storage and processing from the user,s computer on ... storage space and computing power that they can then ... to connect to a single desktop or other computer ... concerns about the increased energy demands of sustaining distributed ... an individual user,s laptop might be shut down when ...
(Date:9/12/2014)... of dendritic cells in human skin have assorted functions ... report researchers in the journal EMBO Molecular Medicine ... the composition of dendritic cells in psoriatic skin lesions ... the disease. , "We urgently need new ways ... to patients and reduce the incidence of known side ...
(Date:9/11/2014)... had a Wisconsin zip code if the originally proposed ... a straight line from the southernmost tip of Lake ... River confluence. University of Illinois soil scientist Ken Olson ... changed, the state of Illinois would have a much ... of the Illinois Territory ceded to Wisconsin when it ...
Breaking Biology News(10 mins):Cutting the cloud computing carbon cost 2Dendritic cells affect onset and progress of psoriasis 2Original northern border of Illinois was south of Chicago and Lake Michigan 2Original northern border of Illinois was south of Chicago and Lake Michigan 3
... and measures, Johns Hopkins researchers have shown that ... mystical/spiritual experiences descriptively identical to spontaneous ones people ... experiences apparently prompt positive changes in behavior and ... , The agent, a plant alkaloid called psilocybin, ...
... Researchers at Cold Spring Harbor Laboratory on Long Island have ... brain is the chief target of the widely prescribed antidepressant ... specific treatments for depression, with fewer side effects, to be ... studies of the factors that control how, when, and where ...
... first time that embryonic stem (ES) cells cultured in ... produce viable offspring. The research, published in the July ... future studies, including investigation of mechanisms involved in sperm ... , Previous studies have shown that ES cells grown ...
Cached Biology News:Hopkins scientists show hallucinogen in mushrooms creates universal 'mystical' experience 2Hopkins scientists show hallucinogen in mushrooms creates universal 'mystical' experience 3Hopkins scientists show hallucinogen in mushrooms creates universal 'mystical' experience 4Prozac's target revealed 2Sperm created in the laboratory from embryonic stem cells produce viable progeny 2
...
... Molecular Probes is pleased to ... for the ultrasensitive detection of primary ... at Indiana University, the ATTO-TAG reagents ... o-phthaldialdehyde (OPA), naphthalene-2,3-dicarboxaldehyde (NDA) and anthracene-2,3-dicarboxaldehyde, ...
Anti-SDF-1β/PBSF affinity isolated antibody lyophilized powder Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline recombinant human SDF-1β/PBSF expressed in E....
... low freezers , Ultima II ... material storage, Ultima II represents the finest, ... general purpose and blood bank configurations, each ... microprocessor control system with built-in voltage boost ...
Biology Products: