Navigation Links
Sangamo BioSciences Announces Presentation of New Data from ZFP Therapeutic® Program in Hemophilia B at American Society for Hematology Meeting
Date:12/13/2011

RICHMOND, Calif., Dec. 13, 2011 /PRNewswire/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced the presentation of new data demonstrating the ability to permanently correct a disease gene in an adult mouse model of hemophilia B using systemic delivery of zinc finger nucleases (ZFNs) at the 53nd Annual Meeting of the American Society of Hematology (ASH).

"We have demonstrated functional correction of a human gene for the clotting factor, Factor IX, with a single, systemic administration of ZFNs in an animal model of disease," said Geoff Nichol, M.B, Ch.B., Sangamo's executive vice president of research and development.  "Our approach enables permanent correction of the genetic defect responsible for hemophilia B.  This circumvents the problems of traditional gene-addition approaches that uncouple the gene from its normal regulatory mechanism and which may result in gene silencing and random gene insertion and potentially lead to malignancy or other unintended consequences."

Abst. No.668 - Robust Factor IX Expression Following ZFN-mediated Genome Editing in an Adult Mouse Model of Hemophilia B (Oral Session: 801)

In this study, scientists demonstrated efficient ZFN-mediated gene correction in an adult mouse model of hemophilia B with a single systemic administration of ZFNs and a donor DNA sequence encoding the corrected human Factor IX gene. Stable levels of protein made from the corrected human gene could be measured in the plasma of the treated animals and resulted in the restoration of normal rates of blood clotting for the period of the study.  This work expands upon earlier studies, published in Nature*, that demonstrated similar results in neonatal mice.  Data described at the ASH meeting demonstrate that growth of liver cells, as is observed in neonates, is not required for efficient
'/>"/>

SOURCE Sangamo BioSciences, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Sangamo BioSciences Announces Presentation at the Lazard Capital Markets 8th Annual Healthcare Conference
2. Sangamo BioSciences Reports Third Quarter 2011 Financial Results
3. Sangamo BioSciences Announces Third Quarter 2011 Conference Call and Webcast
4. Sangamo BioSciences Announces Presentation at the 18th Annual Newsmakers in the Biotech Industry Conference
5. Sangamo BioSciences Announces Presentation at the 2011 UBS Global Life Sciences Conference
6. Sangamo BioSciences Reports Second Quarter 2011 Financial Results
7. Sangamo BioSciences Announces Efficient Generation of Transgenic Pigs Using Zinc Finger Nuclease (ZFN) Technology
8. Sangamo BioSciences Announces Second Quarter 2011 Conference Call and Webcast
9. Sangamo BioSciences Announces Presentation at Two Upcoming Investor Conferences
10. Sangamo Announces Pricing of Public Offering of Common Stock
11. Sangamo Announces Public Offering of Common Stock
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... MA (PRWEB) December 19, 2014 Charm ... MRLAFMQ test for the Detection of Aflatoxin M1 in ... to receive independent third party validation. The peer reviewed ... Unit of the Institute for Agricultural and Fisheries Research ... Group. , Aflatoxin B1, the most toxic aflatoxin ...
(Date:12/19/2014)... BURLINGTON, Mass. , Dec. 19, 2014 ... biomaterial market will grow at a 12 percent compound ... a result of the aging population and the increasing ... Latin America will also spur demand ... results of dental implant and periodontal treatments. ...
(Date:12/19/2014)... Biddeford, ME (PRWEB) December 18, 2014 ... founding director of the Center for Excellence in the ... of New England, has been selected as a member ... He is the first neuroscientist from Maine to receive ... a nonprofit organization supported entirely by the Dana Foundation. ...
(Date:12/19/2014)... San Diego, CA (PRWEB) December 18, 2014 ... announces a limited time special on Sartorius Biohit ... 1 Free on mLINE pipettes, Picus Electronic Pipette Trade-in ... recommended by Health and Safety officers around the world. ... repetitive manual pipetting. Other features include:, , ...
Breaking Biology Technology:Charm Sciences Achieves Independent Validation of First 15 Minute Quantitative Screening Method for Aflatoxin M1 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 2UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 3Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2
... California, August 20 IsoTis, Inc.,(NASDAQ: ISOT ) ... letter dated August 15, 2007 from the US Food ... for,marketing in the US as Class II medical devices. ... Accell Connexus and,Accell Total Bone Matrix, as well as ...
... Thermo Fisher,Scientific Inc. (NYSE: TMO ) announced ... president and chief executive,officer, are adopting stock- trading ... covering the future sale of company stock. Mr.,Dekkers, ... over August,15-17, 2007, has adopted a plan for ...
... awarded Malaysia,s Darjah Yang Mulia Pangkuan Negeri -, ... (TSX: GEN),a company focused on developing simple blood-based ... personalized health management, today,announced that its co-founder and ... Darjah Yang Mulia Pangkuan Negeri (DMPN), a State ...
Cached Biology Technology:IsoTis Receives FDA Clearance for Accell Family of Products 2IsoTis Receives FDA Clearance for Accell Family of Products 3IsoTis Receives FDA Clearance for Accell Family of Products 4Thermo Fisher Scientific Executive Officers Adopting SEC Rule 10b5-1 Trading Programs 2GeneNews CSO Dr. CC Liew awarded state honour by the Government of Malaysia 2
(Date:11/21/2014)... According to a new market ... RFID, Access Control, Intrusion Detection, Parking Management, Under Vehicle ... Service Geography - Global Forecasts to 2020", published by ... be around $25 Billion in 2014 and is expected ... CAGR of 8.69%. Browse 116 market data ...
(Date:11/21/2014)... , Nov. 20, 2014 C-Labs LLC, ... the Internet of Things (IoT), today announced the appointment ... chief operating officer. Previously a strategic advisor to the ... and operations. Mr. Traynor is based out of the ... He reports to Chris Muench , Chief Executive ...
(Date:11/18/2014)... , Nov. 17, 2014   ... and EMC collaborate to develop The Partners Data ... , The Partners Data Lake will allow researcher ... improve diagnostics, treatment and the lives of patients ... research and clinical activities across the Partners system, ...
Breaking Biology News(10 mins):Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5
... today presents a map of normal human genetic variation ... alterations in our chromosomes. In a DNA version of ,spot-the-difference, ... healthy people from Europe, the Americas and East Asia, systematically ... published in Nature , open new approaches for research ...
... the potential to revolutionize the biological understanding of some ... a single protein involved in brain development, called "SRGAP3," ... of mice that cause symptoms that are similar to ... this protein has similar functions in humans, it may ...
... women with breast cancer who do not respond or have ... used alongside traditional chemotherapy and radiotherapy blocks the female ... the tumour to grow; it has been shown to improve ... about one third of patients with the appropriate type of ...
Cached Biology News:Spot the difference 2Single protein targeted as the root biological cause of several childhood psychiatric disorders 2Scientists unravel resistance to breast cancer treatment 2
This bispecific antibody complex has been tested for efficient depletion of CD41+ cells using the StemSep ; negative immunomagnetic cell separation system....
... capable of dynamic scheduling, is designed to ... automation workcells easy for lab personnel, yet ... • Users create methods by ... can build a flowchart, you can write ...
... The Eclipse C1 Plus is a ... highest-quality digital imaging with an ultra-compact and ... of the C1 Plusboost optical performance to ... acquisition.The system alsoincludes support for X and ...
No-Weigh Dithiothreitol (DTT) ,7.7 mg DTT/Tube x 48 tubes...
Biology Products: