Navigation Links
Salk scientists use Amazon Cloud to view molecular machinery in remarkable detail
Date:2/1/2013

In this week's Nature Methods, Salk researchers share a how-to secret for biologists: code for Amazon Cloud that significantly reduces the time necessary to process data-intensive microscopic images.

The method promises to speed research into the underlying causes of disease by making single-molecule microscopy of practical use for more laboratories.

"This is an extremely cost-effective way for labs to process super-resolution images," says Hu Cang, Salk assistant professor in the Waitt Advanced Biophotonics Center and coauthor of the paper. "Depending on the size of the data set, it can save over a week's worth of time."

The latest frontier in basic biomedical research is to better understand the "molecular machines" called proteins and enzymes. Determining how they interact is key to discovering cures for diseases. Simply put, finding new therapies is akin to troubleshooting a broken mechanical assembly line-if you know all the steps in the manufacturing process, it's much easier to identify the step where something went wrong. In the case of human cells, some of the parts of the assembly line can be as small as single molecules.

Unfortunately, in the past conventional light microscopes could not clearly show objects as small as single molecules. The available alternatives, such as electron microscopy, could not be effectively used with living cells.

In 1873, German physicist Ernst Abbe worked out the mathematics to improve resolution in light microscopes. But Abbe's calculations also established the optical version of the sound barrier: the diffraction limit, an unavoidable spreading of light. Think of how light fans out from a flashlight.

According to the Abbe limit, it is impossible to see the difference between any two objects if they are smaller than half the wavelength of the imaging light. Since the shortest wavelength we can see is around 400 nanometers (nm), that means anything 200 nm or be
'/>"/>

Contact: andy Hoang
ahoang@salk.edu
619-861-5811
Salk Institute
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Scientists defuse the Vietnam time bomb
2. Singapore scientists lead human embryonic stem cell study
3. Sheffield scientists shine a light on the detection of bacterial infection
4. Nanowiggles: Scientists discover graphene nanomaterials with tunable functionality in electronics
5. Scientists solve mystery of colorful armchair nanotubes
6. iBioSeminars and iBioMagazine: Free, Online Biology Seminars and Short Talks by Leading Scientists
7. Chinese Scientists Zhen-Yi Wang and Zhu Chen Awarded 7th Annual Szent-Gyorgyi Prize for Progress in Cancer Research
8. Scientists decode brain waves to eavesdrop on what we hear
9. Receptos Scientists Publish Determination of a High Resolution Sphingosine 1-Phosphate Receptor 1 Structure in Science
10. Scientists learn how to out run damage with imaging technique
11. Design eye for the science guy: Drop-in clinic helps scientists communicate data
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Salk scientists use Amazon Cloud to view molecular machinery in remarkable detail
(Date:2/27/2015)... The fully automated supercritical fluidic ... sequentially analyze up to 48 samples utilizing automatic ... of targets by mass spectrometry. , The ... measurement requirements of a wide range of applications, ... and search for disease biomarkers, additives in forming ...
(Date:2/27/2015)... 2015 Cytokinetics, Incorporated (Nasdaq: CYTK) announced ... with patients and health care advocates in the United ... Day®. Rare Disease Day is dedicated to elevating ... the special challenges faced by patients with rare diseases ... proud to stand alongside patients and caregivers representing the ...
(Date:2/26/2015)... N.J. , Feb. 26, 2015 On ... and its affiliated companies, Wilentz, Goldman & Spitzer, ... trade secrets lawsuit against Genewiz Inc. in excess of ... and utilized GenScript,s trade secrets, and that it improperly ... entered an order denying motions for judgment notwithstanding the ...
(Date:2/26/2015)... 26, 2015   Regulus Therapeutics Inc . (NASDAQ: ... discovery and development of innovative medicines targeting microRNAs, today ... and Chief Executive Officer of Regulus, will present a ... Annual Healthcare Conference on Wednesday, March 4, 2015 ... at the Boston Marriott Copley Place.  ...
Breaking Biology Technology:Shimadzu Corporation Launches Nexera UC - The World’s Foremost Unified Chromatography System 2Shimadzu Corporation Launches Nexera UC - The World’s Foremost Unified Chromatography System 3Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 2Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 3Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 4Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 5Cytokinetics Joins Global Movement to Raise Awareness for Rare Diseases 6Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 3Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 2Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 3
... Jan. 17 NEXCORE Technology,Inc, a world-class original ... the intellectual property rights for the,development of a ... new system provides significantly greater control over the,inflow/outflow ... on the system are held by Drs. Atul ...
... for Common Document Types Broadens Project Coalition with Addition ... A-Life Medical, QuadraMed, Misys Healthcare, CHICAGO, Jan. 17 ... Types (CDA4CDT) project starts 2008 on a strong,note adding ... 3M Health Information Systems joined in the fall of ...
... MADISON, N.J., Jan. 17 Quest Diagnostics,Incorporated (NYSE: ... information and services, announced that it will report results,for ... and provide,financial guidance for 2008 on February 21, 2008, ... The company is rescheduling its report of fourth quarter ...
Cached Biology Technology:NEXCORE Technology Obtains Licenses for Revolutionary Fluid Management System 2New Benefactors Show Support for CDA4CDT: 2New Benefactors Show Support for CDA4CDT: 3New Benefactors Show Support for CDA4CDT: 4New Benefactors Show Support for CDA4CDT: 5New Benefactors Show Support for CDA4CDT: 6New Benefactors Show Support for CDA4CDT: 7Quest Diagnostics Sets New Date to Report Fourth Quarter and Full Year 2007 Results 2Quest Diagnostics Sets New Date to Report Fourth Quarter and Full Year 2007 Results 3
(Date:2/5/2015)... 2015   Epic Sciences , a precision diagnostics company ... Murali Prahalad , Ph.D., president and CEO, is scheduled ... (PMWC) 2015: Silicon Valley, which is taking place at the ... on January 26-28, 2015. Dr. Prahalad ... Biomarkers." Last year, Epic Sciences was a finalist in the ...
(Date:2/5/2015)... , Jan. 28, 2015 NXT-ID, Inc. ... the "Company"), a biometric authentication company focused on the ... the upcoming RedChip Global Online CEO Conference on January ... Gino Pereira , CEO of NXT-ID will ... lead product, the Wocket smart wallet and its full ...
(Date:1/22/2015)... , Jan. 22, 2015 Research and Markets ... "Biometrics - A Global Market Overview" report to their ... technology is to ensure that an individual is who she/he ... may make use of a person,s unique physical characteristics, such ...
Breaking Biology News(10 mins):Epic Sciences to Present at Personalized Medicine World Conference 2015 on the Use of Circulating Tumor Cells as Cancer Biomarkers 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 2CEO of NXT-ID, Inc. to Discuss Company's Biometric Technologies at RedChip Online Conference January 29th 3Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3
... University scientists have defined a hidden second option plants ... be the first step in boosting plants, nutritional value ... phenylalanine is required to build proteins and is a ... plants, including lignin, which allows plants to stand upright ...
... negative emotions they often use spatial metaphors. A happy person is ... in the dumps. Some researchers believe these metaphors are a clue ... spatial words to talk about emotional states, we also use spatial ... To test this link between vertical space and emotion, in ...
... Human Frontier Science Program Organization (HFSPO) is pleased to ... postdoctoral fellowships, career development awards and research grants. HFSP ... selection in a global competition. The names are available ... HFSP postdoctoral fellowships are given to young scientists ...
Cached Biology News:Second plant pathway could improve nutrition, biofuel production 2To remember the good times, reach for the sky 22010 Human Frontier Science Program awards announced 2
Improves spot morphology and DNA binding to the slide resulting in increased hybridization signal. ID Clarifier: Optimized spotting solution for use with SigmaScreen APS Coated Slides for Microarrays...
... feature a dual strength adhesive system which facilitates ... The adhesives on either side of the frame ... to the glass has an easy release adhesive ... forms a stronger bond. This means that when ...
... the base hold 10 l of water ... around the edges of the coverslip. The ... contamination. This chamber can be used with ... Linkage: This CLS number is a new ...
... cDNA Synthesis and Labeling Kit generates labeled ... First unmodified cDNA is made via a ... an Oligo(dT) primer. Unlike other methods, there ... the reverse transcription reaction. This unmodified cDNA ...
Biology Products: