Navigation Links
Salk scientists use Amazon Cloud to view molecular machinery in remarkable detail
Date:2/1/2013

In this week's Nature Methods, Salk researchers share a how-to secret for biologists: code for Amazon Cloud that significantly reduces the time necessary to process data-intensive microscopic images.

The method promises to speed research into the underlying causes of disease by making single-molecule microscopy of practical use for more laboratories.

"This is an extremely cost-effective way for labs to process super-resolution images," says Hu Cang, Salk assistant professor in the Waitt Advanced Biophotonics Center and coauthor of the paper. "Depending on the size of the data set, it can save over a week's worth of time."

The latest frontier in basic biomedical research is to better understand the "molecular machines" called proteins and enzymes. Determining how they interact is key to discovering cures for diseases. Simply put, finding new therapies is akin to troubleshooting a broken mechanical assembly line-if you know all the steps in the manufacturing process, it's much easier to identify the step where something went wrong. In the case of human cells, some of the parts of the assembly line can be as small as single molecules.

Unfortunately, in the past conventional light microscopes could not clearly show objects as small as single molecules. The available alternatives, such as electron microscopy, could not be effectively used with living cells.

In 1873, German physicist Ernst Abbe worked out the mathematics to improve resolution in light microscopes. But Abbe's calculations also established the optical version of the sound barrier: the diffraction limit, an unavoidable spreading of light. Think of how light fans out from a flashlight.

According to the Abbe limit, it is impossible to see the difference between any two objects if they are smaller than half the wavelength of the imaging light. Since the shortest wavelength we can see is around 400 nanometers (nm), that means anything 200 nm or be
'/>"/>

Contact: andy Hoang
ahoang@salk.edu
619-861-5811
Salk Institute
Source:Eurekalert  

Page: 1 2 3

Related biology technology :

1. Scientists defuse the Vietnam time bomb
2. Singapore scientists lead human embryonic stem cell study
3. Sheffield scientists shine a light on the detection of bacterial infection
4. Nanowiggles: Scientists discover graphene nanomaterials with tunable functionality in electronics
5. Scientists solve mystery of colorful armchair nanotubes
6. iBioSeminars and iBioMagazine: Free, Online Biology Seminars and Short Talks by Leading Scientists
7. Chinese Scientists Zhen-Yi Wang and Zhu Chen Awarded 7th Annual Szent-Gyorgyi Prize for Progress in Cancer Research
8. Scientists decode brain waves to eavesdrop on what we hear
9. Receptos Scientists Publish Determination of a High Resolution Sphingosine 1-Phosphate Receptor 1 Structure in Science
10. Scientists learn how to out run damage with imaging technique
11. Design eye for the science guy: Drop-in clinic helps scientists communicate data
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Salk scientists use Amazon Cloud to view molecular machinery in remarkable detail
(Date:7/28/2014)... 2014 Appistry, Inc. , a ... the power of genomics to next-generation medicine, announced today ... Challenge . , Two Appistry staff will be ... Center for Genome Resources, and Mr. Neil Miller, director ... Kansas City. Rounding out the panel are Appistry’s Dr. ...
(Date:7/28/2014)... -- Research and Markets has announced the addition ... report to their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... used to determine the size of a particle in a ... analyze the size of particles as it can affect the ... to determine the behavior and nature of a material, and ...
(Date:7/25/2014)... bacteria live in each person,s digestive tract. Scientists believe ... stave off harmful infections, but their role in human ... light on the role of these bacteria, a team ... recently tracked fluctuations in the bacterial populations of two ... in the July 25 issue of the journal ...
(Date:7/25/2014)... Pittsburgh, PA (PRWEB) July 25, 2014 ... annual Call for Topics for Conferee Networking. These two-hour ... similar interests to meet and resolve problems, discuss new ... , The deadline to submit a topic for consideration ... at pittcon.org . The Conferee Networking committee will ...
Breaking Biology Technology:Appistry Names Industry Experts from the National Center for Genome Resources and Mercy Children's, Kansas City, to Judge Pipeline Challenge Competition 2Global Particle Size Analysis Market 2014-2018 2Monitoring the rise and fall of the microbiome 2Monitoring the rise and fall of the microbiome 3Pittcon 2015 Announces Call for Topics for Conferee Networking Sessions 2
... the Georgia Institute of Technology have made important findings ... an electrical field on a surface-supported gold nanocluster changes ... flat structure. In another paper, they relate their discovery ... magnetic through oxygenation of gold nanowires. They also found ...
... ETEX Corporation, an advanced,biomaterials company, announced today that ... Health, Inc., Under the agreement, LifeNet Health ... to be mixed with ETEX,s proprietary,calcium phosphate to ... will manufacture EquivaBone(TM) in its Cambridge,facilities and market ...
... IOMI ) today announced that it will release fourth ... and hold a,conference call and live webcast to discuss ... 1:30 p.m. Eastern Time., Conference Call Details, ... 6 at 1:30 p.m.,Eastern Time via phone, please dial ...
Cached Biology Technology:Physicists discover gold can be magnetic on the nanoscale 2Physicists discover gold can be magnetic on the nanoscale 3Physicists discover gold can be magnetic on the nanoscale 4ETEX and LifeNet Health, Inc. Enter Agreement 2Iomai to Announce Fourth Quarter and Year-End 2007 Financial Results and Host Webcast on Thursday, March 6 2
(Date:7/28/2014)... wild relative of the domestic tomato, has been published ... headed by Professors Neelima Sinha and Julin Maloof at ... genome information may help breeders produce tastier, more stress-tolerant ... journal Nature Genetics , was lead by Bjrn ... UC Davis labs carried out work on the transcriptome ...
(Date:7/28/2014)... of a new study suggest two ways to effectively address ... well in obese women, compared to women of a normal ... method, researchers say, but as the population has increased in ... for obese women. Studies have consistently found that obesity has ... may in turn affect how well the pill prevents pregnancy. ...
(Date:7/28/2014)... Jude Children,s Research Hospital study found that 73 percent ... their risk of developing metabolic syndrome and related health ... results appear in the current issue of the journal ... 1,598 adult survivors of childhood cancer in the study ... factors like high blood pressure, abdominal obesity, elevated triglyceride ...
Breaking Biology News(10 mins):Strategies identified to improve oral contraceptive success with obese women 2Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 2Unhealthy habits more than double risk of metabolic syndrome in childhood cancer survivors 3
... dominates a plant,s growth principally because it was there first, ... the plant. Collaborating teams from the University of ... Canada combined their expertise in molecular genetics and computational modelling ... encourages plants to thrive. Understanding of the action and ...
... , , , ... that a new market research report is available in its catalogue. ... Market , , http://www.reportlinker.com/p0119500/World-Dynamic-Signature-Verification-Market.html ... for Dynamic Signature Verification in US$ Thousands. The market for Dynamic ...
... RESTON, Virginia, September 17 WCC Smart Search ... for multi-modal fusion, today,announced that it has been selected ... their driver registration system. ELISE ID will be used,to ... existing databases,that contain over 20 million records. It will ...
Cached Biology News:Explaining why pruning encourages plants to thrive 2Reportlinker Adds World Dynamic Signature Verification Market Report 2Reportlinker Adds World Dynamic Signature Verification Market Report 3Reportlinker Adds World Dynamic Signature Verification Market Report 4Reportlinker Adds World Dynamic Signature Verification Market Report 5Reportlinker Adds World Dynamic Signature Verification Market Report 6Reportlinker Adds World Dynamic Signature Verification Market Report 7Reportlinker Adds World Dynamic Signature Verification Market Report 8Reportlinker Adds World Dynamic Signature Verification Market Report 9
Rabbit polyclonal to Testosterone 19 ( Abpromise for all tested applications). Antigen: Testosterone 19 CME HSA (Human)...
Kinase Buffer can be used to assay protein kinase activity...
Anti-Kusabira Orange Monoclonal Antibody Description: 100 g Research Focus: tag Storage: -20C Shipping Temperature: 4C...
alpha/beta-Tubulin Antibody Ship: Hot Store: -20 C...
Biology Products: