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Roche Real-Time HIV Test is Faster and Less Labor-Intensive Than Competitor's

Roche test processes 50 percent more samples in 1-day shift

INDIANAPOLIS, Sept. 14 /PRNewswire/ -- Roche Diagnostics' newly developed, automated real-time PCR test for HIV provides shorter turnaround time and less hands-on labor than one of its main competitors, according to a new study published in Clinical Chemistry and Laboratory Medicine in July.

The study, conducted by Medical Laboratory Bremen, concludes that Roche's new HIV-1 test used with the COBAS(R) Ampliprep/COBAS(R) TaqMan(R) (CAP/CTM) can save laboratories 30 minutes of workflow time and can process up to 50 percent more samples in a one-day shift, compared with Abbott's RealTime HIV test using m2000sp and m2000rt.

The research compared 102 plasma samples from HCV patients, 109 samples from HIV patients and 10 samples from negative donors. Roche has filed with the U.S. Food & Drug Administration for approval to use the HCV test on the CAP/CTM in the United States. The widely used, semi-automated COBAS Amplicor Monitor assay served as the reference test.

"The results indicate that real-time PCR assays can improve on the efficiency of end-point PCR tests by better covering viral dynamic ranges and providing high throughput and automation," said Dr. Dietmar Wolff, author of "Comparison of the Roche COBAS Amplicor Monitor, Roche COBAS Ampliprep/COBAS Taqman and Abbott RealTime Test assays for quantification of hepatitis C virus and HIV RNA."

In addition, the study highlighted some key performance differences between the COBAS Ampliprep/COBAS Taqman and Abbott RealTime assays using m2000sp and m2000rt.

Workflow is so critical to laboratories that Wolff wanted to develop a practical measurement by running the systems at full capacity in a one-day shift simulation.

"CAP/CTM could process 72 samples in a one-day shift, while RealTime could only process 48 samples," Wolff said. "This difference is due to the significant reduction in manual intervention required by CAP/CTM, an integrated system in which samples are processed for extraction and real-time PCR by two dedicated instruments physically linked by a robotic arm."

About Roche and the Roche Diagnostics Division

Headquartered in Basel, Switzerland, Roche is one of the world's leading research-focused healthcare groups in the fields of pharmaceuticals and diagnostics. As a supplier of innovative products and services for the early detection, prevention, diagnosis and treatment of diseases, the Group contributes on a broad range of fronts to improving people's health and quality of life. Roche is a world leader in diagnostics, the leading supplier of drugs for cancer and transplantation and a market leader in virology. In 2006, sales by the Pharmaceuticals Division totaled 33.3 billion Swiss francs, and the Diagnostics Division posted sales of 8.7 billion Swiss francs. Roche employs roughly 75,000 people in 150 countries and has R&D agreements and strategic alliances with numerous partners, including majority ownership interests in Genentech and Chugai. Roche's Diagnostics Division offers a uniquely broad product portfolio and supplies a wide array of innovative testing products and services to researchers, physicians, patients, hospitals and laboratories world-wide. For further information, please visit our U.S. Web site at

All trademarks used or mentioned in this release are legally protected by law.

For further information please contact:

Lori McLaughlin

Corporate Communications

Roche Diagnostics Corporation

Indianapolis, Ind.

Phone: 317-521-3112

SOURCE Roche Diagnostics Corporation
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