Navigation Links
Researchers create the world's most advanced genetic map
Date:7/20/2011

the role those differences play in human health. In that respect, the first draft of the human genome, completed a decade ago, was only a starting point for understanding the genetic origins of disease.

As researchers begin to parse those differences, a crucial tool is a genetic map, which in this case was based on where recombination has occurred across the genome. Recombination, together with mutation, accounts for all the genetic (and thus physical) variety we see within species. But while mutation refers to the errors introduced into single locations within genomes when cells divide, recombination refers to the process by which huge chunks of chromosomes are stitched together during sexual reproduction.

But this stitching process only occurs at specific locations. In a prior landmark set of papers, Myers and his colleagues identified a DNA code, or motif, that attracted part of the recombination machinery, a gene called PRDM9. Knowing the motif, a string of 13 DNA letters, researchers could zero in on the locations where recombination typically occurredthe "recombination hotspots."

"When recombination goes wrong, it can lead to mutations causing congenital diseases, for example diseases like Charcot-Marie-Tooth disease, or certain anemias," said Myers. "We found the same 13 base motif marking many of these disease mutation sites."

Explained Reich, "The places in the genome where there are recombination hotspots can thus also be disease hotspots. Charting recombination hotspots can thus identify places in the genome that have an especially high chance of causing disease."

The researchers discovered that the 13 base-pair motif that is responsible for many of the hotspots in Europeans accounts for only two thirds as much recombination in African Americans. They connected the remaining third to a new motif of 17 base pairs, which is recognized by a version of the recombinational machinery that occurs almost exclusive
'/>"/>

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0442
Harvard Medical School
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Penn researchers show single drug and soft environment can increase platelet production
2. SANYO and BD Biosciences Collaborate to Offer Researchers Valuable Technology and Research Tools
3. TUM researchers develop environmentally friendly process to improve storage stability of probiotics
4. Researchers image graphene electron clouds, revealing how folds can harm conductivity
5. Researchers clarify properties of confined water within single-walled carbon nanotube pores
6. Researchers engineer the environment for stem cell development to control differentiation
7. Penn researchers break light-matter coupling strength limit in nanoscale semiconductors
8. Researchers From More Than 30 Countries Share Findings About the Use of Ultrasound in the Prevention, Diagnosis and Treatment of Heart Disease
9. Singapore researchers invent broadband graphene polarizer
10. Livermore researchers develop battery-less chemical detector
11. Researchers create terahertz invisibility cloak
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2015)... 21, 2015 Patent Offering, The patent’s ... diagnostic or therapeutic imaging within a body lumen (open ... endoscope having a low cost, single-use disposable illumination and ... was October 18, 2013 and the patent approval was ... the physician to customize the lighting and magnification of ...
(Date:5/21/2015)... , May 21, 2015 /PRNewswire/ - RepliCel Life ... stage regenerative medicine company focused on the development ... poster presentation at the International Society for Cellular ... chronic Achilles tendinosis currently in a Phase 1/2 ... 29 th from 5:30 PM to 7:00 ...
(Date:5/20/2015)... DUBLIN , May 20, 2015 Research and ... addition of the "Top Technologies in HW_Technical Insights" ... division of this report evaluated technology trends in the ... trends that are likely to have an impact in ... depth analysis of the top 10 health and wellness ...
(Date:5/20/2015)... The global genotyping market is expected to grow at ... 2015 to 2020 to reach $17.0billion in 2020. Genotyping ... development process and to provide personalized therapy, factors that ... by key manufacturers to offer advanced and innovative products ... 113 market data tables & 37 figures spread through ...
Breaking Biology Technology:IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 2IpAuctions™ Presents The Worlds Smallest Disposable Illuminated Endoscope For Auction 3RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 2RepliCel to Present Unique Autologous Cell Treatment for Achilles Tendinosis at International Society for Cellular Therapy Conference 3Top Technologies in the Health and Wellness Industry 2015 2Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 2Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 3Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 4Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 5
... a Madison-based biotechnology company determined to solve the ... $250,000 Technology Development Fund Loan (TDF) from The ... use the low-interest, deferred-payment loan to develop its ... , ,The Technology Development Fund is a spectacular ...
... analysts, consultants and executives are reporting that there are ... second half of 2003, which provides the necessary first ... , ,Steve Haroldson, chief technology officer for CUNA Mutual ... I talk regularly with technology vendors, and over the ...
... CIO magazines CIO Award, given to 100 ... of information technology(IT) within their enterprises. Alliant Energy, Lands ... the award, announced in the August 15 issue of ... the cover of the magazine. , ,The magazine says ...
Cached Biology Technology:IT Spending to Increase in Second Half of 2003 2IT Spending to Increase in Second Half of 2003 3IT Spending to Increase in Second Half of 2003 4IT Spending to Increase in Second Half of 2003 5Five Wisconsin Non-Tech Companies Win IT Awards 2Five Wisconsin Non-Tech Companies Win IT Awards 3Five Wisconsin Non-Tech Companies Win IT Awards 4
(Date:5/21/2015)... According to a new ... Software, Services), by Applications (Surveillance (Airborne, Maritime, Land), ... (Military & Defense & Commercial) - Global Forecast ... is expected to grow from $7252.0 Million in ... Compound Annual Growth Rate (CAGR) of 6.6%. ...
(Date:5/20/2015)... 20, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... owned subsidiary, 3D-ID LLC, a company engaged in biometric ... the biometrics technology portion of the recently awarded TIES ... Department of the Army. 3D-ID LLC has ... government, law enforcement and security agencies. ...
(Date:5/19/2015)... 2015 Research and ... of the  "Genetic Testing Market Outlook 2018" ... , ,A recent report, Genetic Testing Market ... the current and future genetic testing market. ... working principles and types are covered in ...
Breaking Biology News(10 mins):Thermal Imaging Market Worth $9,998.9 Million by 2020 2Thermal Imaging Market Worth $9,998.9 Million by 2020 3Thermal Imaging Market Worth $9,998.9 Million by 2020 4NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 2NXT-ID, Inc Announces Participation as Member of Team Battelle for TIES Contract Award 3Global Genetic Testing Market Outlook 2018 2
... CHICAGO , Sept. 16, 2013  AUTOTESTCON –  Marvin ... Systems ), a trusted provider of innovative test solutions ... company,s involvement in AUTOTESTCON 2013 . The 49th ... Chicago, Illinois for ATE leaders ...
... A new understanding of the essential role of gut microbes ... with some of the more significant health problems facing people ... a new analysis. Problems ranging from autoimmune disease to ... to immune dysfunction that begins with a "failure to communicate" ...
... He heads the Institute for Diabetes and Obesity (IDO) ... director of the Helmholtz Diabetes Center (HDC). The Alexander ... Diseases at the Technische Universitt Mnchen (TUM). His research ... of fat and sugar metabolism, with the objective of ...
Cached Biology News:Marvin Test Solutions Featured at AUTOTESTCON 2013 with Leading Armament Experts and Test Systems 2Marvin Test Solutions Featured at AUTOTESTCON 2013 with Leading Armament Experts and Test Systems 3Gut microbes closely linked to proper immune function, other health issues 2Gut microbes closely linked to proper immune function, other health issues 3