Navigation Links
Researchers advance toward engineering 'wildly new genome'
Date:10/19/2013

In two parallel projects, researchers have created new genomes inside the bacterium E. coli in ways that test the limits of genetic reprogramming and open new possibilities for increasing flexibility, productivity and safety in biotechnology.

In one project, researchers created a novel genomethe first-ever entirely genomically recoded organismby replacing all 321 instances of a specific "genetic three-letter word," called a codon, throughout the organism's entire genome with a word of supposedly identical meaning. The researchers then reintroduced a reprogramed version of the original word (with a new meaning, a new amino acid) into the bacteria, expanding the bacterium's vocabulary and allowing it to produce proteins that do not normally occur in nature.

In the second project, the researchers removed every occurrence of 13 different codons across 42 separate E. coli genes, using a different organism for each gene, and replaced them with other codons of the same function. When they were done, 24 percent of the DNA across the 42 targeted genes had been changed, yet the proteins the genes produced remained identical to those produced by the original genes.

"The first project is saying that we can take one codon, completely remove it from the genome, then successfully reassign its function," said Marc Lajoie, a Harvard Medical School graduate student in the lab of George Church. "For the second project we asked, 'OK, we've changed this one codon, how many others can we change?'"

Of the 13 codons chosen for the project, all could be changed.

"That leaves open the possibility that we could potentially replace any or all of those 13 codons throughout the entire genome," Lajoie said.

The results of these two projects appear today in Science. The work was led by Church, Robert Winthrop Professor of Genetics at Harvard Medical School and founding core faculty member at the Wyss Institute for Bi
'/>"/>

Contact: David Cameron
david_cameron@hms.harvard.edu
617-432-0441
Harvard Medical School
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. New England Biolabs Introduces Polbase, an Information Repository of Scientific Data for Polymerase Researchers
2. In new quantum-dot LED design, researchers turn troublesome molecules to their advantage
3. Multidisciplinary team of researchers develop world’s lightest material
4. Researchers shrink tumors and minimize side effects using tumor-homing peptide to deliver treatment
5. Innovative MetaMorph® NX Software Shatters Barriers Between Researchers and Image Analysis Goals with Exclusive Visual Workflow
6. UCLA researchers demonstrate fully printed carbon nanotube transistor circuits for displays
7. Penn and Brown researchers demonstrate earthquake friction effect at the nanoscale
8. Two Top Biological Imaging Centers Offer Powerful Free Online Tool to Researchers, Educators, and Public
9. Researchers develop one of the worlds smallest electronic circuits
10. MU researchers identify key plant immune response in fight against bacteria
11. Researchers realize high-power, narrowband terahertz source at room temperature
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2015)... , April 23, 2015 BioTE Medical ... his book "Age Healthier Live Happier - Avoiding Over-Medication ... the Age Management Medicine Group Conference at JW Marriott ... 2015. ",Age Healthier Live Happier, is a ... avoid over-medication and searching for a higher quality of ...
(Date:4/23/2015)... 23, 2015 Follow us ... a series of genetic tests that determine individual ... Gehrig's disease, Huntington's disease, and Alzheimer's disease. Predictive ... composition and interaction in diseased tissue/cells to understand ... as the response to treatment, such as in ...
(Date:4/23/2015)... 23, 2015 Glemser Technologies ... first EMC® Enterprise Content Division (ECD) Certified Solution ... EMC Documentum® for Life Sciences Solution Suite . ... and capabilities to provide life sciences companies of ... , The EMC Documentum Solution Suite offers four ...
(Date:4/23/2015)... 23, 2015 /PRNewswire/ - Crystal Research Associates, LLC announced ... ® (EIO) on Aeterna Zentaris Inc. (NASDAQ: ... on Crystal Research Associates, website at www.crystalra.com ... at www.aezsinc.com . Aeterna Zentaris ("Aeterna" ... company in oncology, endocrinology, and women,s health. With a ...
Breaking Biology Technology:Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 3Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 2Increasing Disease Prevalence & Focus on Preventive Healthcare Drive the Predictive Diagnostics Market, According to a New Report by Global Industry Analysts, Inc. 3Glemser Earns Accreditation for Life Sciences Solution Suite 2Crystal Research Associates, LLC Issues Executive Informational Overview (EIO) on Aeterna Zentaris Inc. 2Crystal Research Associates, LLC Issues Executive Informational Overview (EIO) on Aeterna Zentaris Inc. 3
... Mass., Aug. 3, 2011 ... medicine, was awarded the American Association of Neuromuscular & ... Accreditation with Exemplary Status. EMG Laboratory has provided ... in and around Merrimack Valley and Cape Cod since ...
... Neuralstem, Inc. (NYSE Amex: CUR ) ... contract to develop its human neural stem cell technology ... contract, entitled "Research to Treat Cancerous Brain Tumors with ... with Principal Investigator John Zhang, MD, PhD, Professor of ...
... 2, 2011 Anadys Pharmaceuticals, Inc. (Nasdaq: ANDS ... financial results on Monday, August 8, 2011, after the U.S. ... call and webcast on Monday, August 8, 2011, at 5:00 ... financial results and highlights.  A live webcast of the call ...
Cached Biology Technology:EMG Laboratory Attains Prestigious National Accreditation for Clinical Excellence in Neuromuscular Diagnosis 2EMG Laboratory Attains Prestigious National Accreditation for Clinical Excellence in Neuromuscular Diagnosis 3Neuralstem Awarded Department of Defense Contract for Brain Cancer Research 2Neuralstem Awarded Department of Defense Contract for Brain Cancer Research 3Anadys Pharmaceuticals to Report Second Quarter 2011 Financial Results 2
(Date:3/24/2015)... DUBLIN , Mar. 24, 2015 Research and Markets ... "Face and Voice Biometrics - Global Strategic Business Report" report ... for Face and Voice Biometrics in US$ Thousands by the following ... analytics for the US, Canada , ... , Middle East & ...
(Date:3/24/2015)... March 24, 2015   Crossmatch ™, a ... announced that its U.are.U ® 4500 Fingerprint ... Goorin Bros . to achieve PCI compliance for ... access to the POS terminal, protecting the retailer ... data breaches. With one-third of ...
(Date:3/23/2015)...   HOYOS Labs , a leading global authentication ... the Company will demonstrate multiple biometrics-based technologies under its ... Connect:ID on March 23 through 25, 2015, in ... the IEEE Biometric Open Protocol Standard; free biometrics-based consumer ... control system. BOPS was invented by HOYOS Labs and ...
Breaking Biology News(10 mins):Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 2HOYOS Labs to Showcase Host of Biometrics Technologies at Connect:ID in Washington, D.C. 3
... of Education and Human Development,s Department of Health and Kinesiology, ... Texas Chapter of the American College of Sports Medicine (ACSM),s ... will deliver lectures at a series of Texas educational institutions ... big honor for both Bill and our department," said Wan ...
... a previously unknown structure in between a liquid and ... long oily chains, according to Purdue University researchers. However, ... Water plays a huge role in biological processes, from ... that this transformation is useful in a way not ...
... LLC, creator of the Selman Surgical Rehearsal Platform (SRP), ... to University Hospitals (UH) Case Medical Center in Cleveland, ... Physicians at the medical center have been instrumental in ... that the institution becomes the first to own the ...
Cached Biology News:UTSA physiologist William Cooke named 2013 Lecture Series Speaker by Texas Sports Medicine Chapter 2Oil and water: An icy interaction when oil chains are short, but steamy when chains are long 2Oil and water: An icy interaction when oil chains are short, but steamy when chains are long 3Surgical Theater, LLC sells first Surgical Rehearsal Platform to UH Case Medical Center 2Surgical Theater, LLC sells first Surgical Rehearsal Platform to UH Case Medical Center 3
MBS 384 well satellite block unit with height adjusting heated lid, 384 well block holds 1 x 0.04 ml 384 well plate...
Multidrop DW is a high-speed automated dispenser for Deep Well plates, 1.1 ml test tubes and 96-well plates. Designed for accuracy and precision, the Multidrop DW dispenses up to eight different reag...
ma. plate stack height 70mm...
... MBS Satellite Thermal Cycler (MBS) ... solution for medium to high ... combines the latest in satellite ... and PC control, resulting in ...
Biology Products: