Navigation Links
Research could lead to new drugs for major diseases
Date:6/11/2012

Researchers at the University of Gothenburg, Sweden, are working to develop substances that can prevent parasites, bacteria and fungi from producing essential proteins, research that could, in the long term, lead to new drugs for several major diseases.

The World Health Organization (WHO) has announced that aminoacyl-tRNA synthetases a type of enzyme are important targets for the development of new drugs for several major diseases such as cancer, various parasitic diseases and bacterial and fungal infections.

These enzymes are involved in the production of proteins (protein synthesis) in all organisms. Their job is to ensure that the right amino acid is linked to the growing protein chain. These enzymes are essential for all living organisms.

Challenging research field

Researchers at the University of Gothenburg are currently undertaking basic research in this challenging field. The aim is to prevent the enzyme from producing proteins in bacteria, parasites or fungi, without stopping it from functioning in the human body.

"We're collaborating with researchers in several countries," says researcher Itedale Namro Redwan. "Our role has been to design and to synthesise substances that can be used for the development of drugs against parasitic diseases."

Looking for an effective substance

The enzymes' job of ensuring that the right amino acid is linked to the growing protein chain works in the same way in all types of cell, be they human or parasitic.

"The real challenge is identifying substances that act on enzymes in the parasite alone, without affecting the human enzymes at the same time," says Itedale Namro Redwan, who is making substances that can prevent bacterial and parasitic enzymes from functioning, but do not affect human enzymes. If this proves possible, it will help in the development of drugs for several major diseases.

"One of our main objectives has been to produce potent and selective substances that can be used to gain understanding of how these enzymes work. A greater understanding of their function would contribute to the development of medication for diseases like elephantitis."

Could prevent major diseases

Elephantitis, also known as filiaris, affects more than 120 million people in the developing world, and is caused by a worm that lives in the infected person's lymphatic vessels.

The potentially active molecules are being designed using computer-based molecular modelling techniques, with the resulting molecules subsequently synthesised via various chemical reactions.

"One of the best things about being a medicinal chemist is getting to plan a synthetic pathway that'll result in a specific substance, starting the reaction and then realising that the reaction's has worked," says Itedale Namro Redwan. "Better still is finding out that the molecule has performed as expected in a biological test."

The activity of the synthesised substances is assessed by partners through biological testing on, for example, aminoacyl-tRNA synthetase isolated from E. coli or filiaris parasites.


'/>"/>
Contact: Itedale Namro Redwan
itedale.namro@chem.gu.se
46-031-786-9097
University of Gothenburg
Source:Eurekalert  

Related biology technology :

1. Wolters Kluwer Research Now Available via Bloomberg Tradebook
2. ACORN Research, LLC Announces Partnership with AdeptBio, LLC
3. New England Biolabs Introduces Polbase, an Information Repository of Scientific Data for Polymerase Researchers
4. Researching graphene nanoelectronics for a post-silicon world
5. In new quantum-dot LED design, researchers turn troublesome molecules to their advantage
6. BBVA Foundation Unites the Efforts of Massachusetts General Hospital and Barcelonas Vall dHebron Hospital in Biomarker Research for Personalized Cancer Therapies
7. New research points to benefits of innovative cobas® HPV test for primary screening as Englands cervical cancer screening programme includes the test in current HPV "triage" rollout
8. Multidisciplinary team of researchers develop world’s lightest material
9. K computer research results awarded ACM Gordon Bell Prize
10. ResearchMoz: Ophthalmic Devices Market to 2017 - Glaucoma and Cataract Surgery Devices, Minimally Invasive Procedures in Ophthalmic Surgery to Drive the Ophthalmic Surgery Market
11. Researchers shrink tumors and minimize side effects using tumor-homing peptide to deliver treatment
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research could lead to new drugs for major diseases
(Date:4/27/2017)... ... April 27, 2017 , ... Sierra Instruments announces ... capillary thermal mass flow technology provide exponentially more accurate mass flow data than ... of all industrial processes—such as those involving chemical reactions, combustion, respiration, pharmaceutical, and ...
(Date:4/27/2017)... ... April 27, 2017 , ... The Council for ... goes to Jayson Lusk, a consummate communicator who promotes agricultural science and technology ... science, as he explains how innovation and growth in agriculture are critical for ...
(Date:4/26/2017)... CALIF. (PRWEB) , ... April 26, 2017 , ... ... Lajollacooks4u, San Diego’s premiere team-building and cooking events company, offers one-of-a-kind gifts, ... , Menus specialize in California cuisine, and guests leave inspired with new ...
(Date:4/26/2017)... ... 2017 , ... LABS, Inc. (LABS) announced in December 2016 that two ... Nucleic Acid Testing (NAT) for ZIKV; and Enzyme Immunoassays (EIAs) specific for IgM and ... for blood donors under an Investigational New Drug (IND) study protocol. , Now, ...
Breaking Biology Technology:
(Date:3/16/2017)... CeBIT 2017 - Against identity fraud with DERMALOG solutions "Made in Germany ... ... one project, multi-biometric solutions provide a crucial contribution against identity fraud. (PRNewsFoto/Dermalog Identification Systems) ... Used combined in one project, multi-biometric solutions provide a crucial contribution ... ...
(Date:3/9/2017)... and MOUNTAIN VIEW, Calif. , March ... Made Simple," and 23andMe , the leading personal ... food choices.  Zipongo can now provide customers with personalized ... health goals and biometrics, but also genetic markers impacting ... Zipongo,s personalized food decision support platform uses ...
(Date:3/6/2017)... 2017 Mintigo , the leader ... Predictive Sales Coach TM , its new artificial ... into Salesforce. This unique AI application will allow ... with deep knowledge of their customers and prospects ... Predictive Sales Coach extends Mintigo,s existing customer success ...
Breaking Biology News(10 mins):