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Research Team led by JCVI Scientists Uncover More Complexity and Detail in Southern African Genomic Diversity
Date:3/14/2013

histories. In this study, the Ju/'hoan represent a pure Khoesan lineage with no significant non-Khoesan contribution. The Ju'/hoan are arguably one of the last pure 'hunter-gatherer' populations in the world today. Unlike most global populations, the Ju'/hoan in this study not only lacked signatures of gene-based adaption to agriculture, they carry genetic contributions essential for forager survival. The !Xun however, although culturally, linguistically and genetically Khoesan, showed significant male-derived non-Khoesan African ancestral contribution, while the data suggests that contemporary !Xun speakers once represented two unique Khoesan prehistories.

Conversely, the amaXhosa Southern Bantu speakers all showed a comparable female-derived ancient Khoesan contribution. This is the first genome-wide analysis of the Baster people, who like their Coloured cousins carry a significant female-derived Khoesan contribution. However, this study provides a genetic basis for the Baster/Coloured distinction. The Khoesan, non-Khoesan African, European and Asian contributions to the Coloured and Baster populations, represent arguably the most diverse human genomic profiles within single population identifiers.

According to Dr. Hayes, "We believe that research like ours is important not only to better understand some of the oldest and most genetically diverse human populations on the planet, but can also lead to better understanding of the impact of admixture on the study of disease genes."

Researchers at the following organizations were part of this research study: the Scripps Translational Science Institute, The Scripps Research Institute, University of New South Wales Faculty of Medicine, The Garvan Institute of Medical Research, University of Stellenbosch Department of Pathology and Department of Surgical Sciences Urology Division, Institute of Genomics and Integrative Biology/Indian Genome Variation Consortium in India, 
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SOURCE J. Craig Venter Institute
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