Navigation Links
Research: Dosage of Morphine for ill Newborns Still too Imprecise
Date:12/22/2009

LEIDEN, The Netherlands, December 22 /PRNewswire/ -- Dosage recommendations for newborns being cared for in an intensive care unit will in the future most likely be based on more individual characteristics than just body weight. This is the result of a study conducted by the Dutch Top Institute Pharma in which Leiden University (Prof M. Danhof) and the Rotterdam Erasmus Medical Centre/Sophia Children's Hospital (Prof D. Tibboel) are represented.

Catherijne Knibbe, clinical pharmacologist from the Leiden/Amsterdam Centre for Drug Research of Leiden University: "For morphine the preliminary study results show that for example a quarter of the current standard dose is sufficient for premature babies. The Erasmus MC/Sophia Children's Hospital had already noted in practice that some babies experienced withdrawal symptoms after long-term treatment with morphine. Now research has shown that the required amount of morphine can vary greatly per baby."

The dosage for children is often adjusted solely according to body weight, but that now seems to be insufficient. Knibbe said about the common used sedative midazolam: "A healthy child may be prescribed far more midazolam than for example a child with the same body weight lying in the intensive care unit with a severe infection. This study provides guidelines for arriving at a dosage recommendation that is adjusted better to the individual child. This is an enormous advance." According to Knibbe, this information is very important for doctors, as well as for pharmaceutical companies, which have been required for the past two years to conform to stricter European legislation for medicinal products for children.

This study required an intensive collaboration between clinical pharmacologists and pediatricians from the various institutes using modern methods like PK/PD modeling. Complex computer models can determine the correct dosage from small quantities of blood,
'/>"/>

SOURCE Top Institute Pharma
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. ISMPP Announces Publication of Good Publication Practice for Communicating Company-Sponsored Medical Research: GPP2 Guidelines Published in the BMJ
2. Important Step Forward in Osteoarthritis Research: Bioactive Collagen Peptides Stimulate the Regeneration of Cartilage Tissue
3. Setting the Benchmark for Winery Tasting Room Research: An Emerging Region Gets a Global Perspective
4. New Weapon in BioDefense Research: NanoLogix Kit Speeds Rapid Diagnostics of Anthrax and Bubonic Plague
5. Encouraging high-risk research: DFG approves funding for 2 new Reinhart Koselleck projects
6. U-M research: New plastic is strong as steel, transparent
7. FDA Approves Additional Dosage Strengths of Shires ADHD Treatment VYVANSE(TM) (lisdexamfetamine dimesylate) Which May Help Physicians Tailor Treatment for Individual Patients
8. Nastech Enters Into Feasibility Study to Develop a Non-Injectable Dosage Form of Factor IX to Control Bleeding
9. Sanofi Pasteurs Investigational H5N1 Influenza Vaccine Achieves High Immune Response at low Dosage
10. ETHEX Corporation Voluntarily Recalls Specific Lots of 30 mg. and 60 mg. Morphine Sulfate Extended Release Tablets Due to the Potential for Oversized Tablets
11. New Multi-Center Study Finds Masimo SET Pulse Oximetry Screening Significantly Improves Detection of Congenital Heart Disease in Newborns
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... 2014  Sangamo BioSciences, Inc. (NASDAQ: SGMO ... and accomplishments. For the second quarter ... loss of $7.0 million, or $0.10 per share, compared ... per share, for the same period in 2013. As ... equivalents, marketable securities and interest receivable of $236.7 million. ...
(Date:7/23/2014)... , July 23, 2014 /PRNewswire-iReach/ -- Think Drinks are ... for the long term. They are the first functional ... sustained energy as an alternative to the temporary fix ... on Indiegogo on July 29, 2014, with hopes to ... Photo - http://photos.prnewswire.com/prnh/20140723/129697 ...
(Date:7/23/2014)... -- Having the right people at the table for significant ... and achieving clinical and operational goals. The 22 nd ... 20-22, 2014, in San Diego , ... experts discussing how partnerships have positively impacted their objectives. ... Executive Officer of Cape Regional Medical Center located in ...
(Date:7/23/2014)... MOINES, Iowa (PRWEB) July 23, 2014 ... join the business as vice president of Agricultural Biotechnology ... Mendel Biotechnology where he served most recently as president, ... extensive biotechnology and business leadership in the seed and ... Pioneer,” said Paul E. Schickler , president of ...
Breaking Biology Technology:Sangamo BioSciences Reports Second Quarter 2014 Financial Results 2Sangamo BioSciences Reports Second Quarter 2014 Financial Results 3Sangamo BioSciences Reports Second Quarter 2014 Financial Results 4Sangamo BioSciences Reports Second Quarter 2014 Financial Results 5Sangamo BioSciences Reports Second Quarter 2014 Financial Results 6Sangamo BioSciences Reports Second Quarter 2014 Financial Results 7Sangamo BioSciences Reports Second Quarter 2014 Financial Results 8Sangamo BioSciences Reports Second Quarter 2014 Financial Results 9truBrain Neuroscientists To Launch More Effective, Healthier Alternative To Energy Drinks On Indiegogo 2MSC and Cape Regional Medical Center Partner to Improve Cost, Quality and Outcomes 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 3
... announces that a new market research report is ... Health of Biotechnology and Drugs Industry in India ... The research services examines the financial ... 2 broad parameters- Excellence in financial management and ...
... Regeneron Pharmaceuticals, Inc. (Nasdaq: REGN ) will ... Healthcare Conference on Monday, January 10, 2011.  The presentation ... Eastern Time).  The session may be accessed through the ... Relations page.  An archived version of the presentation will ...
... Using advanced technology to create high-quality dental lab ... mission of DentalLab.com ( http://www.dentallab.com ), a new full-service ... States and around the world. DentalLab.com was ... Holovchenko, an entrepreneur with a successful track record of ...
Cached Biology Technology:Reportlinker Adds Financial Health of Biotechnology and Drugs Industry in India and China 2Cutting-Edge Technologies Position DentalLab.com as Emerging Leader in Dental Lab Services Outsourcing 2
(Date:7/24/2014)... by the University of York has carried out the ... Indian Ocean. , The results, reported in the ... in the management of marine protected areas, with almost ... in the region now under local community stewardship. ... seas and coasts designed to protect wildlife from damage ...
(Date:7/24/2014)... his work with a new drug that successfully treated lupus ... has received a $250,000 grant to expand his research to ... treat a wider range of autoimmune diseases., Chandra Mohan, Hugh ... at UH, previously published a study in Arthritis Research & ... treated lupus in mice and reduced the number of cases ...
(Date:7/24/2014)... release is available in German . ... to recognize and respond to threats to health, and ... detailed understanding of the mechanism underlying immunologic memory, however, ... have converged to support the hypothesis that the persistence ... cells with stem-cell-like potential. Until now, there was no ...
Breaking Biology News(10 mins):Western Indian Ocean communities play vital role in conservation 2Biomedical engineer looks at new applications for novel lupus drug 2Biomedical engineer looks at new applications for novel lupus drug 3Experiments prove 'stemness' of individual immune memory cells 2Experiments prove 'stemness' of individual immune memory cells 3
... the biological sciences, mankind has struggled to comprehend the ... the arthropods. Now, a team of researchers, including Dr. ... History Museum of Los Angeles County (NHM), has finished ... the arthropods, answering many questions that defied previous attempts ...
... the Earth,s climate to slow or reverse global warming ... discussion. But before effective action can be taken, the ... Two Northwestern University studies, both published online recently by ... -- clues as to what drove large-scale changes to ...
... flies, has revealed a critical step in fly vision. Humans ... manifest as visual defects ranging from mild visual impairments to ... Biology paves the way for using the fruit fly ... Retinal dystrophies result from inherited defects in nearly every ...
Cached Biology News:Where did insects come from? 2Where did insects come from? 3The carbon cycle before humans 2The carbon cycle before humans 3All eyes on retinal degeneration 2
PTC-100 cycler with gold/silver block with Hot Bonnet heated lid, holds one 96-well V-plate or96x0.2ml tubes...
... Multimode Detectors provide unmatched value and ... and automation needs. Capable of performing ... the same instrument, the DTX Series ... can be integrated seamlessly with Beckman ...
... Deparaffinization Solution is available in a ... easy-to-use reagent for dewaxing paraffin-embedded tissue ... situ hybridization, or other analytical methods. ... consists of dipping the slides in ...
... The MJ Mini thermal cycler is a compact ... x 0.2 ml tubes, 12 x 0.5 ml ... heated lid uses a thumbwheel to adjust height ... oil-free cycling. Peltier heat pumps provide excellent thermal ...
Biology Products: