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Date:6/3/2010

Inhibition of influenza virus by siRNAs 95

Limitations of RNAi approach to influenza 96

Challenges and future prospects of siRNAs for influenza 96

Antisense approaches 97

NEUGENE® antisense for inhibition of multiple strains of influenza A 97

Nanoviricides against influenza 97

Other innovative approaches 98

Abatacept 98

Polymeric coatings to inactivate influenza virus 98

Cytotoxic therapy 98

Cyanovirin 99

Fludase 99

Multiferon® 99

Pyrrolidine dithiocarbamate 100

T-705 100

Value of antivirals in preventing spread of influenza after exposure 100

Resistance to influenza therapy and efforts to overcome it 100

NIAID Centers of Excellence for research on pandemic influenza viruses 101

Research on influenza viruses at Bayer 101

Concluding remarks and future prospects 102

8. AIDS/HIV 103

Introduction 103

Epidemiology 103

Current concepts of pathomechanisms 103

Decoding the structure of an entire HIV genome 104

Pathogenesis of AIDS 104

Host-pathogen interactions that regulate HIV-1 replication 105

Visualization of the interaction of HIV-1 proteins with target cells 105

Genentic basis of
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