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Date:6/3/2010

6. Competitive Assessment of Antiviral Approaches 69

Introduction 69

An ideal antiviral agent 69

SWOT analysis 69

Concluding remarks 72

7. Influenza Viruses 73

Introduction 73

Clincal features of influenza 73

Colds due to rhinovirus 73

Effects of influenza on the respiratory system 73

Effect of avian influenza on the nervous system 74

Epidemiology 74

Supermap of avian influenza 74

Influenza A 74

Avian influenza affecting humans 75

Human influenza versus avian influenza 75

H1N1 influenza 77

Immune system and influenza 78

Immune Epitope Database and Analysis Resources 78

Anti-influenza approaches 78

Pharmaceuticals 79

Neuraminidase inhibitors 79

Mechanism of action 79

Tamiflu 80

Zanamivir 80

CS-8958 80

Peramivir 80

Resistance to neuraminidase inhibitors 81

Adverse effects of neuraminidase inhibitors 82

Other drugs for influenza 82

Adamantanes 82

Probenecid 83

Current recommendations for the use of antiviral agents for influenza 83


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