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Date:6/3/2010

Monoclonal antibodies 33

Bavituximab 34

Treatment of viral infection with radiolabeled MAbs 34

Limitations of MAbs and measures to overcome these 35

Interferon-based approaches 35

Novel antiviral approaches 35

Synthetic modified hypericin compounds 35

Targeting Toll-like receptors 36

Potential and drawbacks of TLR-ligands in viral diseases 37

Inhibition of viral transport from cytoplasm into the cell nucleus 37

Nitric Oxide based antiviral therapeutics 37

Gene therapy for viral infections 38

Antisense approaches to viral infections 38

Antisense oligonucleotides 38

Limitations of antisense oligonucleotides as antivirals 39

NEUGENE antisense 39

RNAi screens of viral genomes 40

RNAi for treatment of viral infections 40

Promise and pitfalls of RNAi gene therapy 42

Management of rapidly evolving pathogens 42

Personalized medicine and viral diseases 43

An integrated approach to viral diseases 43

Current problems and needs in antiviral therapy 43

3. Vaccines for Virus Infections 45

Introduction 45

Types of vaccines 46

Live attenuated virus vaccines 46

DNA vaccines 46


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