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Date:6/3/2010

NTENTS

0. Executive Summary 17

1. Introduction to Virology 19

Introduction 19

Virus databases 19

A practical classification of viruses 19

Pathomechanism of viral diseases relevant to therapy 20

Intrinsic host defense against retroviruses 21

Life cycle of virus as basis for antiviral approaches 22

Genetic switch in virus infections 22

Viral-induced cancer 23

Prophylaxis versus therapy 24

Economic impact of viral diseases 24

Historical landmarks in the development of antiviral therapies 24

2. Antiviral Approaches 27

Classification 27

Antiviral drug discovery and development 27

Viral versus cellular targets for antiviral therapy 27

Antimicrobial peptides 29

Immunological approaches 29

Basics of immune regulation in relation to viruses 29

Effect of viruses on the immune system 30

Latent viral infections and the immune system 30

Immunomodulating agents 31

Amplification of innate immunity 31

Enhancers of immune system 31

Promoting immune-mediated clearance of a chronic viral infections 31

Immunoglobulins 32

Bovine lactoferrin 32

Quercetin 32


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