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Date:6/3/2010

ral strategies 27

Table 2 2: Viral vs cellular targets for discovery of antivirals 28

Table 2 3: Viruses amenable to antisense oligonucleotides 39

Table 2 4: Inhibition of viral replication by RNAi 42

Table 3 1: Types of vaccines for viral diseases 46

Table 4 1: Role of nanobiotechnology in virology 53

Table 5 1: Methods of delivery of antiviral agents 59

Table 5 2: Role of nanotechnology for improving delivery of antivirals 64

Table 5 3: Commercially available liposomal antiviral vaccines 65

Table 6 1: SWOT of monoclonal antibodies 69

Table 6 2: SWOT of agents that prevention viral entry into cells 70

Table 6 3: SWOT of drugs interfering with intracellular replication 70

Table 6 4: SWOT of protease inhibitors 70

Table 6 5: SWOT of integrase inhibitors 70

Table 6 6: SWOT of maturation inhibitors 70

Table 6 7: SWOT of neuraminidase inhibitors 71

Table 6 8: SWOT of targeting Toll-like receptors (TLRs) 71

Table 6 9: SWOT of topical antivirals agents against viral infections 71

Table 6 10: SWOT of gene therapy, antisense oligonucleotides, RNAi 71

Table 6 11: SWOT of vaccines 71

Table 6 12: SWOT of NanoViricides 72

Table 7 1: Anti-influenza approaches 79

Table 7 2: Antiviral drugs used for influenza 79

Table 8 1: Drugs in clinical development for HI
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