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Clinical trials of HCV therapeutics 182

Limitations to the development of effective anti-HCV therapeutics 183

Causes of treatment failure in chronic hepatitis C 183

HCV drug resistance 183

Personalized management of HCV infection 183

Future needs in HCV therapy 184

Summary and concluding remarks 185

10. Miscellaneous Commercially Important Virus Infections 187

Introduction 187

Herpes viruses 187

Herpes simplex virus 187

Treatment of HSV-1 187

Acyclovir 187

Vaccine for HSV 188

Antisense therapy for HSV-1 188

Herpes simplex virus 2 and genital herpes 188

Famciclovir 189

Intravaginal microbicidal agents for HSV-2 189

Vaccine for HSV-2 189

Herpes simplex keratitis 190

Herpes simplex encephalitis 190

Limitations of current HSV therapies 191

Herpes zoster virus 191

Herpes zoster and chicken pox 191

Epidemiology of herpes zoster 191

Treatment of herpes zoster 191

Herpes zoster vaccine 192

Cytomegalovirus 192

Valganciclovir hydrochloride 192

T-cell therapy for CMV 193

Vaccine for CMV 193

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