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Date:6/3/2010

ated delivery of anti-HIV siRNAs 149

Bispecific siRNA constructs 149

Role of the nef gene during HIV-1 infection and RNAi 149

siRNA-directed inhibition of HIV-1 infection 150

Synergistic effect of snRNA and siRNA 151

Targeting CXCR4 with siRNAs 151

Targeting CCR5 with siRNAs 151

Concluding remarks on RNAi approach to HIV/AIDS 152

Companies involved in developing gene therapy for HIV/AIDS 152

Conclusions regarding gene therapy of HIV/AIDS 153

Testing for new anti-HIV therapies 153

Personalized approach to management of HIV 154

Differences in response of the body to HIV 154

Variations in action of drugs on HIV 154

Drug-resistance in HIV 154

Replication Capacity measurement 155

Role of biomarkers in management of HIV/AIDS 155

Prevention of adverse reactions to antiviral drugs 156

Nanoviricides as a personalized approach to HIV 156

Concluding remarks and future prospects 156

9. Hepatitis Viruses 159

Introduction 159

Hepatitis A virus infection 159

Hepatitis E virus infection 159

Epidemiology 159

Structure of the HEV 160

HEV vaccines 160

Epidemiology of HBV 160

Pathogenesis of HBV-induced liv
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