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tease inhibitors 119

Overcoming HIV-1 resistance to PIs 119

PPL-100 120

Entry inhibitors targeting CCR5 receptor 120

Maraviroc 121

SP-01A 121

MAbs targeting CCR5 receptor 121

PRO 140 122

Ibalizumab 122

Integrase inhibitors 123

Raltegravir (Isentress) 123

Elvitegravir (GS 9137) 124

Design of fusion inhibitor peptides against enfuvirtide-resistant HIV-1 124

Maturation inhibitors 124

Blocking of pre-integration complex translocation 125

Immune enhancers 125

Pyrimidinediones 126

Novel combinations of drugs for prevention of AIDS 126

Truvada 126

Combination of raltegravir, enfuvirtide, and darunavir 126

Other innovative antiviral approaches against HIV/AIDS 127

Enhancing immune response by blockade of PD-1 receptor 127

IL-2 as adjunct to antiretroviral therapy 127

A filtration device for HIV-1 as an adjunct to the immune system 127

In vitro evaluation of antiviral drug activity 128

Methods for sustaining antiviral activity 128

Selective targeting of ITK to block multiple steps of HIV replication 128

Drugs from natural sources 129

Anti-HIV activity of drugs that stimulate cholesterol efflux 12

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