Navigation Links
Rapid-Acting Antidepressants Reviewed by NeuroPerspective
Date:12/11/2012

CARDIFF, Calif., Dec. 11, 2012 /PRNewswire/ -- NI Research has released the December issue of NeuroPerspective, which features a comprehensive review of pharmacotherapies for depression, with a particular focus upon the programs developing RAADs, rapid-acting antidepressants, an approach that springs from the reports of accelerated depression relief via the use of ketamine.

This 29-page issue includes:
1) An overview of the biology of depression and the implications of accelerated treatment effect for our understanding of depression and pathways for intervention.

2) A review of the many therapeutic strategies that are currently under development, with a special focus upon glutamatergic approaches, those which access the NMDA receptor and associated modulator components. These constitute the pathways for RAADs, where symptom relief may occur in hours, rather than weeks.

Among the programs reviewed, the leaders in the race for a RAAD include:

Naurex, whose Phase IIa data for IV GLYX-13 was just released. In spite of the fact that this was a 116pt dose-ranging study in TRD patients, limited by the small cohort sizes for each of the active treatment groups, GLYX-13 exceeded expectations. Most importantly, none of the doses produced psychotomimetic effects in any patients. The pilot study now requires confirmation from the multiple-dose PhIIb trial underway.

Various Ketamine and Ketamine-combination drugs: These programs are hoping to skirt the risk of psychotomimesis via a variety of tactics. Programs in this vein are underway at JNJ/Addex, Lilly, AstraZeneca, Washington University, Yale, and Mt. Sinai.

AstraZeneca's IV AZD6765 has been tested more extensively than most of its competitors, but it is relatively slow to achieve therapeutic effect, and psychotomimetic concerns are not completely alleviated.

Naurex has an orally bioavailable version of GLYX-13, NRX-1074, approaching IND-readiness. If it
'/>"/>

SOURCE NI Research
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Peer Reviewed Clinical Study Shows New Blood Test More Accurately Predicts Risk Of A Heart Attack
2. Alzheimers Therapeutics Reviewed by NeuroPerspective
3. Peer-reviewed Article Reports ProImmune's Immune Formulation 200® Activates the Immune-Support Gene Nrf2.
4. Nucleic Acids Research Journal Publishes Sapphire Energy Peer-Reviewed Research Paper on a Chloroplast Genome From Green Algae
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... 30, 2014 FemCap Inc., www.femcap.com  an ... receipt of a patent No: US, 8,795,248 B2 dated ... received FDA clearance in the U.S., 510(K) K121857, medical ... Europe. This patent is related to its menstrual cup with ... company is releasing FemmyCycle Teen, a third menstrual cup ...
(Date:9/30/2014)... SoundConnect, an award ... dedicated to supporting business communication solutions, including business ... a carrier services specialist has joined ... connected and productive at all times. This growth ... businesses to cloud communications services. On a ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Back in the ... 500 square feet. per employee, which included space for circulation ... then.” says Jeff Howell, partner at Nidea Corporate Real ... in Toronto. “By the year 2000, however, 250 square ... seeing that number come down to 175 to 225 square ...
(Date:9/29/2014)... 2014  Ten of the most highly-respected physicians ... regeneration, allograft reconstruction and research and development, as ... to discuss the future of cartilage regeneration at ... symposium, Cartilage Regeneration: State of the Art ... Minced Juvenile Allograft, and State of the Art ...
Breaking Biology Technology:The FemmyCycle 2SoundConnect Expands Carrier Services Division 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 2ITRA Global Reports on How Companies Are Squeezing More Employees into Less Office Space 3World Renowned Experts Discuss Future Of Cartilage Regeneration 2World Renowned Experts Discuss Future Of Cartilage Regeneration 3
... DIEGO, Aug. 8 Halozyme Therapeutics, Inc.,(Nasdaq: ... targeting the extracellular matrix, today reported financial,results for ... 2008., "As we,ve previously stated, we continue ... programs that target large markets. Now we are,beginning ...
... -- China Sky One,Medical, Inc. ("China Sky One ... a,manufacturer, marketer and distributor of pharmaceutical, medicinal and,diagnostic ... conduct a,conference call at 10:00 a.m. Eastern Time ... 2008 financial results., Joining Mr. Yan-qing Liu, ...
... 8 Insmed Inc. (Nasdaq:,INSM), a developer of follow-on biologics and ... 30, 2008., Recent Company Highlights, -- Follow-on Biologics ... bioequivalence of INS-19, the ... factor (G-CSF), to Neupogen(R), an FDA-approved G-CSF product for ...
Cached Biology Technology:Halozyme Therapeutics Reports 2008 Second Quarter Financial Results 2Halozyme Therapeutics Reports 2008 Second Quarter Financial Results 3Halozyme Therapeutics Reports 2008 Second Quarter Financial Results 4Halozyme Therapeutics Reports 2008 Second Quarter Financial Results 5Halozyme Therapeutics Reports 2008 Second Quarter Financial Results 6Halozyme Therapeutics Reports 2008 Second Quarter Financial Results 7Halozyme Therapeutics Reports 2008 Second Quarter Financial Results 8Halozyme Therapeutics Reports 2008 Second Quarter Financial Results 9China Sky One Medical, Inc. Announces Conference Call to Discuss Second Quarter 2008 Results 2China Sky One Medical, Inc. Announces Conference Call to Discuss Second Quarter 2008 Results 3Insmed Announces Financial Results for Second Quarter and Six-Months Ended June 30, 2008 2Insmed Announces Financial Results for Second Quarter and Six-Months Ended June 30, 2008 3Insmed Announces Financial Results for Second Quarter and Six-Months Ended June 30, 2008 4Insmed Announces Financial Results for Second Quarter and Six-Months Ended June 30, 2008 5Insmed Announces Financial Results for Second Quarter and Six-Months Ended June 30, 2008 6Insmed Announces Financial Results for Second Quarter and Six-Months Ended June 30, 2008 7Insmed Announces Financial Results for Second Quarter and Six-Months Ended June 30, 2008 8Insmed Announces Financial Results for Second Quarter and Six-Months Ended June 30, 2008 9Insmed Announces Financial Results for Second Quarter and Six-Months Ended June 30, 2008 10
(Date:9/30/2014)... conducted by the Ocean Health Index rates the ... overall health. In addition, for the first time, ... ocean regions beyond national jurisdiction (high-seas areas) ... safeguarding biodiversity and providing sustainable food sources. , ... a partnership led by scientists from UC Santa ...
(Date:9/30/2014)... Ecker, a Salk professor and Howard Hughes Medical ... have been named recipients in the 2014 round ... (NIH) through the BRAIN (Brain Research through Advancing ... The grant, announced September 30, provides more than ... over three years. , The BRAIN Initiative, launched ...
(Date:9/30/2014)... almost any aquatic environment on Earth, but when the ... pushed to the limit. The amount of time needed ... how different species cope in the future, reveals a ... published in the scientific journal Proceedings of the ... thanks to increasing levels of greenhouse gases in the ...
Breaking Biology News(10 mins):Rating the planet's oceans 2Rating the planet's oceans 3Salk scientists receive $3 million for BRAIN Initiative grant 2Shape up quickly -- applies to fish, too! 2
... When neurons started dying in Clive Svendsen,s lab dishes, ... cells the same type lost in patients with ... that the University of Wisconsin-Madison stem cell biologist had ... lab, using stem cells derived from a patient. ...
... left Africa over 60,000 years ago in a migration that ... population that exist outside Africa today. Now, researchers ... that exodus. By tracing variations in the X chromosome and ... probably outnumbered women in that migration. The scientists expect that ...
... Deep inside the Frasassi cave system in Italy and more ... ropes of microbes growing in the cold water, according to ... microbiology paradise. Many different types of organisms live in the ... professor of geosciences. "We are trying to map which organisms ...
Cached Biology News:Patient-derived induced stem cells retain disease traits 2Patient-derived induced stem cells retain disease traits 3Unusual microbial ropes grow slowly in cave lake 2
...
... is the research-grade spectrofluorometer with a minimum ... S/N ratio 200 or greater for the ... especially designed to keep in mind in ... kinetics, stopped-flow, titration, or anisotropic measurements. ,The ...
... Microarrays designed for genome-wide microRNA expression ... and powerful Paraflo microfluidic on-chip synthesis ... part of our comprehensive microRNA Expression ... The Arabidopsis microRNA Microarray contains ...
... Microarrays designed for genome-wide microRNA expression profiling ... Paraflo microfluidic on-chip synthesis platform. These microarrays ... microRNA Expression Profiling Service. Probe ... all known cow microRNAs (108 unique mature ...
Biology Products: