Navigation Links
RPCI-Led Study: FAK Inhibitor Proves Effective Against Brain Tumors in Preclinical Studies
Date:12/29/2012

more effective treatments for glioblastoma,” noted senior author William G. Cance, MD, FACS, Surgeon-in-Chief and Chair of the Department of Surgical Oncology. “The potential impact is great because glioblastomas are such an aggressive tumor, and because we know they produce FAK in especially high quantities.”

The authors also included researchers from the University of California at San Diego and faculty from the Department of Pathology at RPCI. CFAK-Y15 is being developed by CureFAKtor Pharmaceuticals LLC (http://www.curefaktor.com). Drs. Cance and Golubovskaya, both of whom also serve on the management team of CureFAKtor, were part of the team that first identified CFAK-Y15, in research published in the Journal of Medicinal Chemistry in 2008.

The new abstract and paper, “Pharmacological blockade of FAK autophosphorylation decreases human glioblastoma tumor growth and synergizes with temozolomide,” can be accessed online at http://mct.aacrjournals.org/content/early/2012/12/12/1535-7163.MCT-12-0701.

This work was supported by Susan Komen for the Cure Foundation grant BCTR0707148 and three National Cancer Institute (NCI) grants: R01CA065910, R01HL073396, and the NCI’s Cancer Center Support Grant for Roswell Park Cancer Institute (P30CA016056).

The mission of Roswell Park Cancer Institute (RPCI) is to understand, prevent and cure cancer. RPCI, founded in 1898, was one of the first cancer centers in the country to be named a National Cancer Institute-designated comprehensive cancer center and remains the only facility with this designation in Upstate New York. The Institute is a member of the prestigious National Comprehensive Ca
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

0

GOOD

Page: 1 2 3

Related biology technology :

1. Nature Materials study: Boosting heat transfer with nanoglue
2. New Study: Health Professionals Support Biotechnologys Use In Food Products And Sustainable Farming
3. Nature Materials study: Graphene invisible to water
4. Breaking Study: ICU Medicals Tego® Needlefree Connector Proves More Cost Effective Than Traditional Central Venous Catheter Locks
5. Karyopharm Therapeutics Announces Oral Presentation at the American College of Rheumatology (ACR) on the use of Selective Inhibitors of Nuclear Export (SINE) CRM1 Antagonists in preclinical models of Systemic Lupus Erythematosus (SLE)
6. Array BioPharma To Present Clinical Data At The 2012 ASH Meeting On ARRY-520, A KSP Inhibitor, And ARRY-614, A Dual p38/Tie2 Inhibitor
7. Kinase Inhibitors: Global Markets -- Focus on the U.S.
8. Karyopharm Therapeutics announces the Publication of Two Preclinical Studies on the Activity of Selective Inhibitors of Nuclear Export (SINE) in Acute Myeloblastic Leukemia (AML)
9. Arthritis Therapeutics Market to 2018 - Novel Oral JAK Inhibitors and Biologic Disease Modifying Anti-Rheumatic Drugs (DMARD) Will Drive Continued Growth Across Key Indications
10. Lixte Biotechnology Receives US Patent for Its Proprietary Histone Deacetylase Inhibitor
11. Karyopharm Therapeutics Announces Multiple Presentations on Selective Inhibitors of Nuclear Export (SINE) in Solid and Hematologic Malignancy Models and Spontaneous Canine Cancers at the American Association of Cancer Research (AACR) Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... ALBANY, New York , May 21, 2013 /PRNewswire/ ... published by Transparency Market Research ( http://www.transparencymarketresearch.com ) "Biochip ... Science Research, IVD Tests) - U.S. Industry Analysis, Size, Share, ... USD 2.4 billion in 2011 and is expected to ... 2018, to reach an estimated value of USD 4.7 ...
(Date:5/21/2013)... Biologics, Inc. (NYSE MKT: SYN), a developer of biologics focused ... today that Jeffrey Riley , CEO, will ... Conference on Thursday, May 30, 2013 in New ... Riley is scheduled to present at 10:00 a.m. (Eastern Time). ... be accessed by logging onto the web at http://wsw.com/webcast/marcum/syn/ ...
(Date:5/21/2013)... Mississauga, Ontario (PRWEB) May 21, 2013 ... expert scientists of the ITN to design the ... usefulness of two key clinical models used in ... Chamber (EEC) and Nasal Allergen Challenge (NAC) models. ... supported by numerous publications, to date no direct ...
(Date:5/21/2013)... May 21, 2013 The Formulate Fusion ... solution for sales and marketing teams looking for a fully-functional ... the kit as “everything you’ll need to put together a ... Kit comes with a number of displays and accessories that ... 20 feet by 20 feet in size. These components vary ...
Breaking Biology Technology:The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 2The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 3The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 4The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 5Synthetic Biologics to Present at the 2nd Annual Marcum LLP MicroCap Conference 2Inflamax Research selected by the Immune Tolerance Network and the National Institutes of Health to conduct a landmark clinical study on the underlying mechanisms of allergic inflammation. 2GLM Displays Announces All-in-One Formulate Fusion Fabric Display Kit 2
... Society of Chemical Manufacturers and Affiliates (SOCMA) ... new affiliate group that aims to advance the commercialization ... for the production and processing of chemicals, pharmaceuticals, materials ... to by its acronym, which stands for the Society ...
... Inc. (OTC Pink: DYAI), a global biotechnology company, today ... the first quarter ended March 31, 2012 after market ... a conference call at 5:00 p.m. Eastern Time to ... ) Those wishing to participate in ...
... ALBANY, N.Y., April 24, 2012 AMRI (NASDAQ: ... Business Development and Marketing functions. (Logo: ... American Discovery and Development teams are being combined into ... Conway, who has been promoted to Vice President, Business ...
Cached Biology Technology:SOCMA Announces Launch of SCD-iBIO Group 2AMRI Strengthens Business Development and Marketing Groups 2AMRI Strengthens Business Development and Marketing Groups 3
(Date:5/21/2013)... increasingly being considered in the management of natural ... that can help them recognize and respond to ... their lives. , Place-Based Conservation: Perspectives from ... the Pacific Northwest Research Station,s Linda Kruger, can ... The book is published by Springer Verlag and ...
(Date:5/21/2013)... body, stem cells in the blood often jump ... immune cells that can fight off illness. But ... populations, potentially leading to the development of serious ... of researchers led by biologists at the California ... mouse models, the molecule microRNA-146a (miR-146a) acts as ...
(Date:5/21/2013)... new method for delivering molecules into single, targeted ... The technique could find applications in drug delivery, ... electroporation a technique used to deliver molecules ... membrane that are caused by exposing them to ... of cell transfection. (Cell transfection is the introduction ...
Breaking Biology News(10 mins):Keeping stem cells strong 2Single-cell transfection tool enables added control for biological studies 2
... to plants for reasons that go beyond pollination, according ... issue of Current Biology , a Cell Press ... caterpillars that would otherwise munch on them undisturbed. ... Wrzburg, Germany, earlier found that many caterpillars possess fine ...
... HOUSTON, Dec. 22, 2008 B. Montgomery "Monte" Pettitt, the ... Professor of Physics, Computer Science, Biology and Biochemistry at the ... from the American Association for the Advancement of Science (AAAS). ... among Texas, 16 honorees, six of whom are from Houston ...
... been awarded the distinction of Fellow in the American ... the field of microbial genomics and ecology, particularly for ... Election as a Fellow is an honor ... a presidential professor in OU,s Department of Botany and ...
Cached Biology News:Honeybees as plant 'bodyguards' 2Chemistry professor 1 of only 3 at UH to achieve prestigious AAAS status 2University of Oklahoma researcher named 2008 AAAS Fellow 2
... peptides are molecules of peptidic nature or ... activity which can be developed at the ... agro-food applications. In this way it is ... properties for therapeutic applications. Primm offers a ...
... CLS number is a new ... match Cornings product number. If ... order under the old Sigma-Aldrich ... service for assistance. Material: ...
... forced convection Temperature range 5 C / ... / 212 F Patented APT.line preheating chamber ... controller Timer 0 to 24 h ... tenth of a degree Independent adjustable temperature ...
... Maximize the value of your microarray ... offer the support you need from ... the most up to date methods. ... the Gene Expression Profiling Service or ...
Biology Products: