Navigation Links
RPCI-Led Study: FAK Inhibitor Proves Effective Against Brain Tumors in Preclinical Studies
Date:12/29/2012

Buffalo, NY (PRWEB) December 28, 2012

Researchers from Roswell Park Cancer Institute (RPCI) have published findings from a preclinical study assessing the effectiveness of a small-molecule inhibitor, CFAK-Y15, in treating some brain cancers. The paper, published in Molecular Cancer Therapeutics, demonstrates for the first time that inhibiting the protein focal adhesion kinase (FAK) with CFAK-Y15 is an effective approach to controlling growth of glioblastoma tumors, especially in combination with the standard chemotherapy agent temozolomide (Temodar).

FAK is overexpressed, or produced in excessive amounts, in tumor cells, and has been shown to play a key role in survival of cancer cells. In this study, a team led by Vita M. Golubovskaya, PhD, an Associate Professor of Oncology in the Department of Surgical Oncology, found that animal models treated with CFAK-Y15 demonstrated significantly prolonged survival compared to the control group. CFAK-Y15 provides FAK kinase-specific inhibition by upstream targeting of autophosphorylation sites on the FAK protein. It belongs to a class of ‘two for one’ compounds that also inhibit the oncoprotein Src by inhibiting its autophosphorylation.

“We found that CFAK-Y15 significantly decreased the viability of the glioblastoma cells, and in many cases appeared to cause tumor shrinkage — especially when CFAK-Y15 was given in combination with temozolomide,” noted Dr. Golubovskaya, the paper’s first author. “These compounds target FAK signaling, which is critical for cancer cell and cancer stem cell survival, especially in invasive and metastatic cancers.”

“We’re eager to see this research move to the clinical phase because of the great need for
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2 3

Related biology technology :

1. Nature Materials study: Boosting heat transfer with nanoglue
2. New Study: Health Professionals Support Biotechnologys Use In Food Products And Sustainable Farming
3. Nature Materials study: Graphene invisible to water
4. Breaking Study: ICU Medicals Tego® Needlefree Connector Proves More Cost Effective Than Traditional Central Venous Catheter Locks
5. Karyopharm Therapeutics Announces Oral Presentation at the American College of Rheumatology (ACR) on the use of Selective Inhibitors of Nuclear Export (SINE) CRM1 Antagonists in preclinical models of Systemic Lupus Erythematosus (SLE)
6. Array BioPharma To Present Clinical Data At The 2012 ASH Meeting On ARRY-520, A KSP Inhibitor, And ARRY-614, A Dual p38/Tie2 Inhibitor
7. Kinase Inhibitors: Global Markets -- Focus on the U.S.
8. Karyopharm Therapeutics announces the Publication of Two Preclinical Studies on the Activity of Selective Inhibitors of Nuclear Export (SINE) in Acute Myeloblastic Leukemia (AML)
9. Arthritis Therapeutics Market to 2018 - Novel Oral JAK Inhibitors and Biologic Disease Modifying Anti-Rheumatic Drugs (DMARD) Will Drive Continued Growth Across Key Indications
10. Lixte Biotechnology Receives US Patent for Its Proprietary Histone Deacetylase Inhibitor
11. Karyopharm Therapeutics Announces Multiple Presentations on Selective Inhibitors of Nuclear Export (SINE) in Solid and Hematologic Malignancy Models and Spontaneous Canine Cancers at the American Association of Cancer Research (AACR) Meeting
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... Sergei Filippov (MIPT and Russian Quantum Center at ... Czech Republic, and the Institute of Physics in ... quantum entanglement of particles passing through an amplifier ... distances. Details are provided in an article published ... (see preprint). , Quantum entangled particles are considered ...
(Date:7/23/2014)... Last year, Formedix celebrated its partnership with ... data management solutions for clinical trials. The company launched ... data capture (EDC) and clinical data management. Formedix, a ... added TrialMaster to its Transform for EDC product line. ... TrialMaster, is being released this week, in response to ...
(Date:7/23/2014)... DuPont Pioneer announced today that Neal Gutterson, ... Agricultural Biotechnology (ABT), effective July 21, 2014. Gutterson joins ... as president, chief executive officer and board member. , ... seed and crop protection industry to this integral role ... president of DuPont Pioneer. “I am looking forward to ...
(Date:7/23/2014)... 2014  Sofinnova Ventures, a Menlo Park ... of Sofinnova Venture Partners IX, L.P. at the hard ... initial fund target of $425 million. Sofinnova ... Consistent with recent funds, SVP IX will provide capital ... along with select investments in earlier stage opportunities. Investments ...
Breaking Biology Technology:Scientists find way to maintain quantum entanglement in amplified signals 2Scientists find way to maintain quantum entanglement in amplified signals 3Scientists find way to maintain quantum entanglement in amplified signals 4Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 2Formedix and OmniComm Systems® Partnership Strengthened with the Release of Enhanced TrialMaster® Integration for EDC Build 3DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 2DuPont Pioneer Names Neal Gutterson to Lead Agricultural Biotechnology 3Sofinnova Raises $500 Million Biotech Venture Fund 2
... executives, mostly in denial, are shunning the subject. Smart ones ... general broadcasts. This is a revolution, and the entire model ... , Device Explosion , ,The receptacles to receive the ... but rather handheld devices or the hundreds of gadgets and ...
... Read Part 1 . Winslow Sargeants combination of ... the world of entrepreneurship and risk. His memories of growing ... tenacity is essential. , , Winslow Sargeant ... a child. In June, 1974, U.S. District Court Judge W. ...
... MadCity Murder Mystery game Madison, Wis. ... the UW-Madison School of Education, hopes to bring a ... games, which combine aspects of physical activity, traditional reading ... through the UW System and the Academic ADL ...
Cached Biology Technology:When TV surrenders to Web... 2When TV surrenders to Web... 3Winslow Sargeant: Stepping onto the train called Wisconsin - Part 2 2Winslow Sargeant: Stepping onto the train called Wisconsin - Part 2 3Winslow Sargeant: Stepping onto the train called Wisconsin - Part 2 4Augmented reality brings a new dimension to learning 2Augmented reality brings a new dimension to learning 3
(Date:7/23/2014)... are disappearing, and though conservationists are examining several possible ... rain and light pollution, a key piece of the ... once they leave their breeding sites, and what threats ... answer this question, a team of researchers out of ... map produced for a songbird, using tracking from both ...
(Date:7/23/2014)... 780 million people around the world have no access ... Organization (WHO), 3.4 million people die from water-related diseases ... goal of making a contribution to solving this problem. ... Stark, head of the Functional Materials Laboratory, the 23-year-old ... a prototype. , "What makes our DrinkPure filter unique ...
(Date:7/23/2014)... This news release is available in German . ... shape and stability to cells, drive metabolic processes and ... into complex three-dimensional shapes. Scientists at the Max Planck ... that proteins can be constructed of similar amino acid ... suggests that the proteins that exist today arose from ...
Breaking Biology News(10 mins):York University researchers use bird 'backpacks' to put wood thrushes migration on the map 2ETH student develops filter for clean water around the world 2Protein evolution follows a modular principle 2
... of our hearts and blood vessels. Conventional treatment attempts ... in the blood plasma. The opposite approach, which involves ... acid, has proven unpopular among patients up to now. ... acid has an unpleasant but harmless side-effect: the ...
... November, the Malaspina expedition 2010 will set sail from ... the Spanish National Research Council (CSIC) aims to evaluate ... to survey their biodiversity. The expedition has the backing ... and takes its name from mariner Alessandro Malaspina, the ...
... MADISON, WI, July 26th, 2010 NASA scientists ... and ground-based observations of precipitation. The NASA data ... to monitor non-point pollution and improve water quality. ... of Science Systems and Applications, Inc., incorporated two ...
Cached Biology News:Preventing heart problems while keeping a cool head 2Preventing heart problems while keeping a cool head 3Malaspina expedition 2010 2NASA satellite improves pollution monitoring 2
Request Info...
... combines deep experience, skills and flexibility in ... team chemistry. This combination enables optimum solutions ... beyond.,With AAIBiotech, you can count on our ... than that: its the power of team ...
ZBP-89 (S-15)...
... Physical form: Lyophilized ... salts Preparation Unit Definition: ... 1.0μmole of 2-phosphoglycerate to ... pH7.4 at 25 C. ...
Biology Products: