Navigation Links
Purdue researcher invents molecule that stops SARS
Date:12/23/2008

urnal Proceedings of the National Academy of Sciences.

Mesecar's team screened more than 50,000 chemical compounds for the necessary properties to both block the virus and have the potential to become viable drug treatments.

"Only two of the compounds we tested were identified as having the properties researchers believed could become drugs," said Mesecar, a professor of medicinal chemistry and pharmacognosy. "Using those two compounds, Arun Ghosh and his team increased the potency by almost two orders of magnitude."

Ghosh, who invented the HIV drug darunavir that entered the market in 2007, specializes in improving the treatment properties of molecular inhibitors through structure-based design.

"The design of this inhibitor was a challenge because we did not know the structure of the compound, which shows us how an inhibitor works and what parts need to be amplified or changed," Ghosh said.

Kiira Ratia, a graduate student at the University of Illinois, provided a breakthrough when she captured the X-ray structure of the inhibitor molecule bound to the protein. The structure confirmed that the inhibitor would be a good candidate for drug development because it showed that the inhibitor did not bond too strongly to the protein, Ghosh said.

"This was the first time the structure was revealed and we could see that the inhibitor filled the active site of the protein without using strong covalent bonds," he said. "This is very important for development of a therapeutic treatment because it means there is less of a chance for adverse side effects or toxicity, and the treatment can be easily reversed."

Often a protein involved in the disease process also plays a role in regular human biological processes. A safe and effective treatment needs to block enough of the protein to cripple the disease while not completely eliminating the protein from a person's system. It also must work through interactions tha
'/>"/>

Contact: Elizabeth K. Gardner
ekgardner@purdue.edu
765-494-2081
Purdue University
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Purdue Pharma L.P. Announces Resolution of OxyContin(R) Patent Lawsuit with Mallinckrodt Inc.
2. Purdue leads center to simulate behavior of micro-electromechanical systems
3. Purdue creating wireless sensors to monitor bearings in jet engines
4. Duke researchers coax bright white light from unexpected source
5. Pitt researchers create nontoxic clean-up method for potentially toxic nano materials
6. USC researchers print dense lattice of transparent nanotube transistors on flexible base
7. New Online Video Features Brazilian Researcher Elbio Rech
8. J. Craig Venter Institute Researchers Publish Significant Advance in Genome Assembly Technology
9. Virginia Tech researchers discover how mosquitoes avoid succumbing to viruses they transmit
10. Alfred Mann Foundation for Biomedical Engineering Launches New Web Site Designed to Help University Researchers Bring Biomedical Advances to Market
11. Self-powered devices possible, says Texas A&M researcher
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/22/2014)... RURO, Inc., a leading LIMS, RFID ... version 5.1.4. , RURO’s deployment teams have been ... in RURO’s 8 year history. Many deployments have ... version 5.1.4 is the perfect example – the ... , Limfinity® 5.1.4 release highlights – more than ...
(Date:11/22/2014)... , November 21, 2014 ... wechselt als Chief Commercial Officer zu KLOX    ... der Unternehmensentwicklung und Chief Financial Officer bestellt    ... mit der Vermarktung seines jüngst zugelassenen Behandlungssystems zur Wundheilung ... ("KLOX" bzw. das "Unternehmen") ist sehr erfreut, die folgenden ...
(Date:11/21/2014)... November 20, 2014 Author Matthew J. ... to the Other Side” published as a tribute ... in the “Fiction: Short Story” category of the ... President and CEO of USA Book News, said this ... independent publishers, including Simon & Schuster, Penguin, John Wiley ...
(Date:11/21/2014)... Why did Stephen Hawking become so famous? ... recognizable? Why have they become icons to rival film ... Ratcliffe seeks out the answers to those questions, and ... with science. In " Stephen Hawking Smoked My Socks ... Ratcliffe puts it plainly: , “It is profoundly ...
Breaking Biology Technology:RURO Announces Limfinity® version 5.1.4 2KLOX Technologies meldet Neubesetzung von Führungspositionen 2KLOX Technologies meldet Neubesetzung von Führungspositionen 3KLOX Technologies meldet Neubesetzung von Führungspositionen 4KLOX Technologies meldet Neubesetzung von Führungspositionen 5Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 2Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 3Mystic Ink 's Short Story Collection “A Short Walk to the Other Side” Honoring Ray Bradbury Praised As Award-Winning Finalist In USA Best Book Awards 4“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 2“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 4
... BHRT ) a company committed to delivering ... treat heart failure and,cardiovascular diseases, today announced financial ... Recent Clinical Highlights:, -- On July ... a preclinical,study involving the injection of myoblasts modified ...
... adaptive and assistive technology, MIDDLETOWN, NY and ... of the world,s first commercially available bionic hand,today ... 2008 da Vinci Award from the,National Multiple Sclerosis ... most innovative developments and,research in adaptive and assistive ...
... RICHMOND, Texas, July 30 DNA Heritage has recently,overcome ... severely,restricted the use of DNA testing and databases that ... through their DNA. The patent covers the,use of surnames ... Property Office (UK IPO) has now rendered a formal ...
Cached Biology Technology:Bioheart, Inc. Announces Financial Results for Second Quarter 2008 2Bioheart, Inc. Announces Financial Results for Second Quarter 2008 3Bioheart, Inc. Announces Financial Results for Second Quarter 2008 4Bioheart, Inc. Announces Financial Results for Second Quarter 2008 5Bioheart, Inc. Announces Financial Results for Second Quarter 2008 6Bioheart, Inc. Announces Financial Results for Second Quarter 2008 7Touch Bionics a 2008 da Vinci Award winner 2DNA Heritage Success in Patent Battle Helps Keep Genealogy DNA Test Prices Low 2
(Date:11/7/2014)... Calif. , Nov. 7, 2014  In conjunction with ... Police Departments, The Community Foundation of the Verdugos ... DNA JUSTICE PROJECT," a $250,000 initiative to keep ... initial phase. In its first six months of existence, the ... needed evidence support for local law enforcement. "Because ...
(Date:11/6/2014)... occur because of metastasis, yet progress in preventing ... , "It,s been particularly challenging to design drugs ... fellow in systems biology at Harvard Medical School. ... after they,ve already metastasized." , Gujral and colleagues ... help researchers better understand how metastasis begins. Their ...
(Date:11/5/2014)... in the UTSA College of Sciences, is one ... receive a two-year $300,00 National Science Foundation (NSF) ... funding supports President Obama,s BRAIN Initiative, a federal ... that will demystify complex brain processes. , ... broken into the interactions of multiple components, each ...
Breaking Biology News(10 mins):Community Foundation Of The Verdugos Unveils Campaign To Fund Glendale-Burbank DNA Justice Project 2Migration negation 2Migration negation 3UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3
... been honored by the National Science Foundation with a ... with microfluidic devices, which promise to improve 3D tissue ... University of Texas College of Engineering in 2007, has ... tissue and cells on microchips. , Her devices produce ...
... The Federation of American Societies for Experimental Biology ... inaugural advocacy competition, Stand Up for Science. The competition ... the health, quality of life, or economy of local ... submitted by ,Stand With Science, a group of graduate ...
... the amphibians and reptiles of Sierra Madre Mountain Range, ... 100 species that contribute to the unique biodiversity of the region. ... more than 150 species. Out of these, a total of 49 ... a remarkable 32 endemic. In the world of reptiles, Luzon can ...
Cached Biology News:The amazing amphibians and reptiles of the Philippine island Luzon 2
Anti-human C5/C5b, Clone 568, Monoclonal Antibody...
Transcription factor Sp2. [Source:Uniprot/SWISSPROT;Acc:Q02086] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
... Rabbit monoclonal [EP282Y] to Asparagine ... all tested applications). ... corresponding to residues in the ... Entrez GeneID: ...
Biology Products: