Navigation Links
Primary Progression-Free Survival Endpoint Met in Phase III Study of Nintedanib Plus Docetaxel in Second-Line Advanced NSCLC
Date:6/3/2013

RIDGEFIELD, Conn., June 3, 2013 /PRNewswire/ -- Boehringer Ingelheim Pharmaceuticals, Inc. (BIPI) today announced  results from the Phase III LUME-Lung 1 study showing that the addition of the investigational oncology compound nintedanib* to docetaxel improved progression-free survival (PFS) – the primary endpoint – as a second-line treatment in patients with advanced non-small cell lung cancer (NSCLC) compared to docetaxel alone.1 Secondary endpoints included overall survival (OS).1 These results will be presented today at the 49th Annual Meeting of the American Society of Clinical Oncology (ASCO).

"We are pleased to present the progression-free survival and overall survival data observed with the nintedanib/docetaxel combination in the LUME-Lung 1 clinical trial, in patients with advanced non-small cell lung cancer in the second-line treatment setting," said Berthold Greifenberg , MD, vice president, Clinical Development and Medical Affairs, Oncology, Boehringer Ingelheim Pharmaceuticals, Inc. "These results were selected by ASCO for presentation at a late-breaking oral session at this year's annual meeting."

The trial enrolled 1,314 patients with advanced NSCLC whose disease progressed after first-line chemotherapy.1 Patients were randomly assigned to receive nintedanib plus docetaxel (n=655), a standard second-line chemotherapy, or docetaxel plus placebo (n=659).1

The primary endpoint was PFS as assessed by central independent review; results showed patients treated with nintedanib plus docetaxel lived for a median of 3.4 months before their tumor started to grow again, versus 2.7 months with docetaxel alone (HR 0.79; p=0.0019).1 

The secondary endpoint of OS was evaluated in the full study population, as well as in the sub-group of patients with adenocarcinoma histology &
'/>"/>

SOURCE Boehringer Ingelheim Pharmaceuticals, Inc.
Copyright©2012 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. Nile Therapeutics Announces Top-Line Results in Clinical Trial Evaluating the Subcutaneous Infusion of Cenderitide, Meets Primary Endpoint
2. New research points to benefits of innovative cobas® HPV test for primary screening as Englands cervical cancer screening programme includes the test in current HPV "triage" rollout
3. GeneTex Antibody Company to Launch New Line of Primary Antibodies for the Study of Spindle Assembly
4. Chimerix Antiviral Compound, CMX001, Meets CMV Phase 2 Primary Endpoint in Allogeneic Hematopoietic Stem Cell Transplant Recipients
5. MultiCell Technologies Announces Positive Preclinical Results for MCT-465 and MCT-485 in Primary Liver Cancer In Vitro Models
6. Addisons Disease (Primary or Chronic Adrenal Insufficiency) Therapeutics - Pipeline Assessment and Market Forecasts to 2019
7. Sosei Group Corporation QVA149 Phase III Study Meets Primary Endpoint in Reducing Exacerbations in COPD Patients and Filings in EU and Japan by End of Year
8. Genetic clues to the causes of primary biliary cirrhosis
9. CSL Behring Partners with Pro Supercross Racer Carl Schlacht to Encourage Those with Primary Immunodeficiency to be a "ChamPIon"
10. BioInformatics LLC New Market Report – The Market for Primary Cells & Stem Cell-Derived Cells: Current and Future Opportunities (13-004)
11. Mayo Clinic and ReachMD Launch “Updates from Mayo Clinic” Featuring Expert Interviews and Panel Discussions on Mental Health in Pediatric Primary Care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... , July 28, 2014  InterMune, Inc. (NASDAQ: ... its second quarter 2014 financial results at the close ... live conference call and webcast will be hosted by ... Interested investors and others may participate in ... 212-231-2900 (international), conference ID#21728775. A replay of the webcast and ...
(Date:7/28/2014)... Muncie, IN (PRWEB) July 28, 2014 ... Aeromodeling Center, in Muncie IN, is pleased to announce ... by the National Museum of the United States Air ... than a year-long process that concluded this spring with ... for the Dayton, OH museum. , The National ...
(Date:7/25/2014)... Calif. , July 25, 2014 Amgen ... of Directors today declared a $0.61 per share dividend ... be paid on Sept. 5, 2014, to all stockholders ... Aug. 14, 2014.  About Amgen Amgen ... patients suffering from serious illnesses by discovering, developing, manufacturing ...
(Date:7/25/2014)... 2014 Research and Markets  has ... Market 2014-2018" report to their offering. ... Metabolomics or Metabonomics is the scientific study of ... new experimental technique that is being widely used ... are small molecules that are present in blood, ...
Breaking Biology Technology:InterMune to Release Second Quarter Financial Results on August 6 2AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force 2Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2
... College (CVTC) will receive a $500,000 grant from ... nanotechnology incubator on their Gateway Manufacturing Technology Center in ... systems at the scale of the atom. , ,"Through ... nanotechnology industry can grow, expand, and reach its full ...
... Wis. Small Tree Communications , a ... announced its 10Gb Ethernet solution for Apples Xserve G5. ... Mac OS X Server 10.4 Tiger, the company claims ... ,In addition to proprietary networking drivers, Small Trees solution ...
... Medical imaging software developer Cedara Software and ... for Kodak to offer Cedara B-CAD to its customers ... CARESTREAM Mammography Workstation. , ,Cedara B-CAD is a Computer ... of breast lesions using ultrasound images, providing tools for ...
Cached Biology Technology:
(Date:7/27/2014)... strike that wiped them out if it had taken ... , A fresh study using up-to-date fossil records and ... new narrative of the prehistoric creatures, demise, some 66 ... few million years before a 10km-wide asteroid struck what ... included extensive volcanic activity, changing sea levels and varying ...
(Date:7/27/2014)... have discovered a new species of mayfly in the southern ... India. In fact, this is the first time that any ... collected in peninsular India. , The new species, called ... Soldan for his substantial contribution to the understanding of the ... of a study that describes the new mayfly in the ...
(Date:7/27/2014)... have shown the potential for global climate change to ... most part, ignored the interactions between increasing temperature and ... to damage crops. , A new study involving researchers ... significant, suggesting that policymakers need to take both warming ... , The study looked in detail at global production ...
Breaking Biology News(10 mins):Dinosaurs fell victim to perfect storm of events, study shows 2Study: Climate change and air pollution will combine to curb food supplies 2Study: Climate change and air pollution will combine to curb food supplies 3
... ORLEANSAlzheimer,s disease (AD) is a tragic disease that robs an individual ... the age of 65 now suffer from the disease and one ... to popular belief, Alzheimer,s does not only affect the elderly. Familial ... young as 30. The Study , Alzheimer,s ...
... for adults, teens, and youngsters. It is less clear ... growth during gestation. Now that scientists have determined that, ... a fetus, studies are underway to examine the mother/fetus/exercise/health ... Entitled The Effects of Maternal Exercise on Fetal Breathing ...
... of people around the world, causing numerous problems ranging ... issues. Initial drug use can be motivated by curiosity ... rats, it can also be the result of a ... new study examines the impact of social isolation on ...
Cached Biology News:Computational model examines the pathways of Alzheimer's that strikes at the young 2Effects of maternal exercise on fetal breathing movements 2Early isolation linked to enhanced response to cocaine 2
Human BMP 2 Construction Kit provides antigen affinity purified polyclonal capture and tracer antibodies, and antigen standard for development of approximately ten microplate assays....
...
... pAcGHLT-A,B,C Baculovirus ... Set,pAcGHLT-XylE Baculovirus ... Powder,Thrombin Dilution ... Cocktail,Insect Cell ...
...
Biology Products: