Navigation Links
Penn researchers develop protein 'passport' that help nanoparticles get past immune system
Date:2/21/2013

s, the researchers also attached antibodies of the type that could be used in targeting cancer cells or other kinds of diseased tissue. Beyond a proof of concept for therapeutics, these antibodies also served to attract the macrophages' attention and ensure the minimal peptide's passport was being checked and approved.

"We're showing that the peptide actually does inhibit the macrophage's response," Discher said. "We force the interaction and then overwhelm it."

The test of this minimal peptide's efficacy was in mice that were genetically modified so their macophages had SIRPa receptors similar to human. The researchers injected two kinds of nanoparticles ones carrying the peptide passport and ones without and then measured how fast the mice's immune system cleared them.

"We used different fluorescent dyes on the two kinds of nanoparticles, so we could take blood samples every 10 minutes and measure how many particles of each kind were left using flow cytometry," Rodriguez said. "We injected the two particles in a 1-to-1 ratio and 20-30 minutes later, there were up to four times as many particles with the peptide left."

Even giving therapeutic nanoparticles an additional half-hour before they are eaten by macrophages could be a major boon for treatments. Such nanoparticles might need to make a few trips through the macrophage-heavy spleen and liver to find their targets, but they shouldn't stay in the body indefinitely. Other combinations of exterior proteins might be appropriate for more permanent devices, such as pacemaker leads, enabling them to hide from the immune system for longer periods of time.

While more research is necessary before such applications become a reality, reducing the peptide down to a sequence of only a few amino acids was a critical step. The relative simplicity of this passport molecule to be more easily synthesized makes it a more attractive component for future therapeutics.

'/>"/>
Contact: elerner@upenn.edu
elerner@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3 4

Related biology technology :

1. New England Biolabs Introduces Polbase, an Information Repository of Scientific Data for Polymerase Researchers
2. In new quantum-dot LED design, researchers turn troublesome molecules to their advantage
3. Multidisciplinary team of researchers develop world’s lightest material
4. Researchers shrink tumors and minimize side effects using tumor-homing peptide to deliver treatment
5. Innovative MetaMorph® NX Software Shatters Barriers Between Researchers and Image Analysis Goals with Exclusive Visual Workflow
6. UCLA researchers demonstrate fully printed carbon nanotube transistor circuits for displays
7. Penn and Brown researchers demonstrate earthquake friction effect at the nanoscale
8. Two Top Biological Imaging Centers Offer Powerful Free Online Tool to Researchers, Educators, and Public
9. Researchers develop one of the worlds smallest electronic circuits
10. MU researchers identify key plant immune response in fight against bacteria
11. Researchers realize high-power, narrowband terahertz source at room temperature
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn researchers develop protein 'passport' that help nanoparticles get past immune system
(Date:1/14/2014)... 2014 As pet owners drew up their lists of New ... "Take better care of my furry companion." Nowadays there are pet ... carrying cases to take the little canine or feline darlings along ... to buy some pricey toys at the pet store. But anyone ...
(Date:1/14/2014)... and BETHESDA, Md. , Jan. ... together with two institutes from the National Institutes of ... for bringing safer, more effective treatments to patients on ... Center for Advancing Translational Sciences (NCATS) and the National ...
(Date:1/14/2014)... WESTBOROUGH, Mass. , Jan. 14, 2014  RXi ... on discovering, developing and commercializing innovative therapies addressing ... announced that it received the Notice of Allowance ... on its unique self-delivering RNAi compounds (sd-rxRNA®), for ...
(Date:1/14/2014)... Washington, USA, and Cardiff, UK (PRWEB) January 13, 2014 ... photonics technology development leader with more than 20 years ... society for optics and photonics . Hainsey will serve ... are delighted to have Dr. Hainsey join SPIE as ...
Breaking Biology Technology:New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
... , , , For transfection of a wide variety of cells, ... Features and benefits , , ... No transfection-complex removal needed for most cell lines , Transfection ... sensitive cell lines , High transfection efficiencies and minimal cytotoxicity, ...
... , , , , , ... QIAGEN GmbH, Hilden, Germany , , ... , of neuronal cells by delivery of either siRNA or ... Kosik reported silencing , of endogenous genes in primary rat ...
... , , , , For automated purification of genomic and mitochondrial , ... , Format: , 96-well ... QIAamp DNA Blood MDX Protocol, , ... frozen whole blood (with common anticoagulants , such as citrate and EDTA) , ...
Cached Biology Technology:Effectene Transfection Reagent 2Effectene Transfection Reagent 3Effectene Transfection Reagent 4Efficient DNA transfection of primary CNS neurons using TransMessenger , Transfection Reagent 2Efficient DNA transfection of primary CNS neurons using TransMessenger , Transfection Reagent 3Efficient DNA transfection of primary CNS neurons using TransMessenger , Transfection Reagent 4Efficient DNA transfection of primary CNS neurons using TransMessenger , Transfection Reagent 5Efficient DNA transfection of primary CNS neurons using TransMessenger , Transfection Reagent 6QIAamp DNA Blood BioRobot MDx Kit 2
(Date:4/22/2014)... Scientists at the University of Massachusetts Amherst and ... this week report that they have discovered a new ... of the Negro River in the Amazonia State of ... with Adlia Nogueira and Jos Antnio Alves-Gomes of INPA, ... of the journal Proceedings of the Natural Sciences ...
(Date:4/22/2014)... The Federation of American Societies for Experimental Biology (FASEB) ... (FY) 2013 highlighting how funding from the National Institutes ... DC, and Puerto Rico. "FASEB is pleased to make ... the significance of NIH to their state," said FASEB ... nation,s leading source for biomedical research funding, investing ...
(Date:4/22/2014)... same crystal structure as a mineral first found in ... efficiency charts faster than almost anything researchers have seen ... way of using sunlight to generate electricity may be ... Department,s National Renewable Energy Laboratory (NREL) are analyzing the ... and broad spectrum of expertise to uncover the secrets ...
Breaking Biology News(10 mins):New electric fish genus and species discovered in Brazil's Rio Negro 2NREL unlocking secrets of new solar material 2NREL unlocking secrets of new solar material 3NREL unlocking secrets of new solar material 4NREL unlocking secrets of new solar material 5NREL unlocking secrets of new solar material 6
... BGI has added Applied Biosystems SOLiD System to BGI,s ... Systems have been installed and were thoroughly tested by ... high quality mate-pair data with read lengths up to ... far is 6.8 Gb mappable data per run with ...
... familiar with bar codes, those small black stripes with numbers below, ... on commercial products. We scan them at the grocery store or ... send them in for a rebate. Now imagine scanning a ... dinner to instantly verify the species, where it came from, its ...
... in Belgium have discovered that increasing age affects the way ... they become less likely to be diagnosed with aggressive tumours ... the cancer is increasingly likely to spread, particularly if the ... evidence on aging and lymph node involvement and this study ...
Cached Biology News:FISH-BOL: NOAA researchers help build a global reference library of DNA barcodes 2FISH-BOL: NOAA researchers help build a global reference library of DNA barcodes 3FISH-BOL: NOAA researchers help build a global reference library of DNA barcodes 4Breast cancers behave differently before and after the age of 70 2Breast cancers behave differently before and after the age of 70 3
Request Info...
...
Candida (IgG) -Ab EIA Sample Size: 5 l...
Automated centrifuge for the processing of microplates and tubes; can be integrated into automated process using inexpensive robotics due to its unique sample handling platform....
Biology Products: