Navigation Links
Penn researchers develop protein 'passport' that help nanoparticles get past immune system
Date:2/21/2013

r around it.

Drug-delivery nanoparticles naturally trigger this response, so researchers' earlier attempts to circumvent it involved coating the particles with polymer "brushes." These brushes stick out from the nanoparticle and attempt to physically block various blood serum proteins from sticking to its surface.

However, these brushes only slow down the macrophage-signaling proteins, so Discher and colleagues tried a different approach: Convincing the macrophages that the nanoparticles were part of the body and shouldn't be cleared.

In 2008, Discher's group showed that the human protein CD47, found on almost all mammalian cell membranes, binds to a macrophage receptor known as SIRPa in humans. Like a patrolling border guard inspecting a passport, if a macrophage's SIRPa binds to a cell's CD47, it tells the macrophage that the cell isn't an invader and should be allowed to proceed on.

"There may be other molecules that help quell the macrophage response," Discher said. "But human CD47 is clearly one that says, 'Don't eat me'."

Since the publication of that study, other researchers determined the combined structure of CD47 and SIRPa together. Using this information, Discher's group was able to computationally design the smallest sequence of amino acids that would act like CD47. This "minimal peptide" would have to fold and fit well enough into the receptor of SIRPa to serve as a valid passport.

After chemically synthesizing this minimal peptide, Discher's team attached it to conventional nanoparticles that could be used in a variety of experiments.

"Now, anyone can make the peptide and put it on whatever they want," Rodriguez said

The research team's experiments used a mouse model to demonstrate better imaging of tumors and as well as improved efficacy of an anti-cancer drug-delivery particle.

As this minimal peptide might one day be attached to a wide range of drug-delivery vehicle
'/>"/>

Contact: elerner@upenn.edu
elerner@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3 4

Related biology technology :

1. New England Biolabs Introduces Polbase, an Information Repository of Scientific Data for Polymerase Researchers
2. In new quantum-dot LED design, researchers turn troublesome molecules to their advantage
3. Multidisciplinary team of researchers develop world’s lightest material
4. Researchers shrink tumors and minimize side effects using tumor-homing peptide to deliver treatment
5. Innovative MetaMorph® NX Software Shatters Barriers Between Researchers and Image Analysis Goals with Exclusive Visual Workflow
6. UCLA researchers demonstrate fully printed carbon nanotube transistor circuits for displays
7. Penn and Brown researchers demonstrate earthquake friction effect at the nanoscale
8. Two Top Biological Imaging Centers Offer Powerful Free Online Tool to Researchers, Educators, and Public
9. Researchers develop one of the worlds smallest electronic circuits
10. MU researchers identify key plant immune response in fight against bacteria
11. Researchers realize high-power, narrowband terahertz source at room temperature
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn researchers develop protein 'passport' that help nanoparticles get past immune system
(Date:3/3/2015)... FRANCISCO , March 3, 2015 Kindred Biosciences, ... on saving and improving the lives of pets, announced today ... financial results on March 12, 2015 after the market close. ... Eastern Time that day. Interested parties may ... US, or (484) 756-4262 internationally, and using conference ID 98449349.  ...
(Date:3/3/2015)... DUBLIN , Mar. 03, 2015 Research and ... addition of Jain PharmaBiotech,s new report "RNAi - ... , Because of its ability to silence ... been adopted as the research tool to discriminate gene ... RNAi can be designed to target every gene in ...
(Date:3/3/2015)... March 3, 2015  Synthetic Biologics, Inc. (NYSE MKT: SYN), ... with a focus on protecting the microbiome, announced today that ... present at the 27th Annual ROTH Conference being held on ... in Dana Point, CA. ... 2015 at 1:00 p.m. (Pacific Time). A live ...
(Date:3/2/2015)... PA (PRWEB) March 02, 2015 The ... ReachMD announced today the launch of ... to educate healthcare professionals on the application of human ... The series features peer-to-peer interviews conducted during the ASHG ... ,     Translational Genomics and Health Outcomes Research: What's ...
Breaking Biology Technology:Global RNAi Market Report 2015 - Technologies, Markets and Companies 2014-2024 2Global RNAi Market Report 2015 - Technologies, Markets and Companies 2014-2024 3Synthetic Biologics to Present at the 27th Annual ROTH Conference 2American Society of Human Genetics (ASHG) and ReachMD Launch Series on Genetics and Genomics 2American Society of Human Genetics (ASHG) and ReachMD Launch Series on Genetics and Genomics 3
... Conference Call at 10:30 a.m. ET, May 13 -, ... NTII ) today announced financial,results for its fiscal third quarter ... the three months ended March 31, 2008 were $3.7 million,compared ... Research and development expenses were $5.9 million for the ...
... DIEGO, May 12 Amylin Pharmaceuticals,Inc. (Nasdaq: AMLN ... Conference,on Wednesday, May 14, 2008 at 3:05 p.m. CT ... Vice President, Finance and Chief Financial Officer of,Amylin Pharmaceuticals, ... presentation and breakout session will be webcast, and a,recording ...
... How To Stop The Food Riots. (Atlantic and Latin ... on the,world food crisis with a primer on the ... of control, the worry is that millions more of,the ... Over the past few,months, there have been food-related riots ...
Cached Biology Technology:Neurobiological Technologies Reports Third Quarter Financial Results 2Neurobiological Technologies Reports Third Quarter Financial Results 3Neurobiological Technologies Reports Third Quarter Financial Results 4Neurobiological Technologies Reports Third Quarter Financial Results 5Newsweek International Editions: Highlights And Exclusives, May 19, 2008 2Newsweek International Editions: Highlights And Exclusives, May 19, 2008 3Newsweek International Editions: Highlights And Exclusives, May 19, 2008 4Newsweek International Editions: Highlights And Exclusives, May 19, 2008 5
(Date:2/18/2015)...  Cepheid (NASDAQ: CPHD ) today announced that ... invited investors to participate via webcast. , Cowen and ... Tuesday, March 3, 2015 at 11.20 a.m. Eastern Time ... Wednesday, March 4, 2015 at 10.25 a.m. Eastern ... webcasts for these events, please visit Cepheid,s website at ...
(Date:2/11/2015)... 11, 2015 According ... Control Market by Product (Cards and Readers, Biometrics, Controllers, ... Government, Industrial, Healthcare, Education) and By Geography - Global Forecast and ... the Access Control Market is expected to ... a CAGR of 10.6% between 2014 and ...
(Date:2/5/2015)... 5, 2015  Marken is starting its 35 th ... launched a new marketing campaign to solidify its place ... new campaign focuses on First as a ... The first headline in the series, ... with its client,s priorities. Marken recognizes the need to ...
Breaking Biology News(10 mins):Cepheid to Webcast Upcoming Financial Presentations 2Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4Marken Launches New Patient-Centric Campaign 2
... health benefits of consuming dark chocolate and cocoa mounts, ... and chocolate products deliver the most beneficial compounds, known ... production diminish the levels of cocoa flavanols. ... the effect of conventional production methods of cocoa beans ...
... Orleans, LA LSU oncologist Vince D. Cataldo, MD, ... two chemotherapy drugs now indicated for second and third-line ... remarkably effective in treating a certain subset of these ... at LSU Health Sciences Center New Orleans School of ...
... Montreal, QC March 10, 2011 In childhood, boys and ... peers. Around early adolescence, they gradually begin to include ... in Journal of Research on Adolescence suggests ... The findings show that girls tend to initiate the ...
Cached Biology News:Study clarifies the role of cocoa bean handling on flavanol levels 2Study shows new treatment strategy effective for certain lung cancers 2Early male friendship as a precursor to substance abuse in girls 2
Monoclonal antibodies conjugated with rhodamine...
... [RET-P1] to Rhodopsin Rhodopsin is a ... mammals, birds, amphibians, and reptiles. The rhodopsin ... in the retina. Immunogen: ... Specificity: This antibody specifically labels ...
... 3′-(α-Amino- p- methoxyhydrocinnamamido)-3′-deoxy-N,N-dimethyladenosine, 2HCl ... FROM MOISTURE. Protein synthesis inhibitor. Inhibits ... nascent polypeptide chains. Induces DNA fragmentation ... leukemia cells. Purity: ≥98% by ...
5X StabilCoat Immunoassay Stabilizer is a 5X concentrate solution of StabilCoat Immunoassay Stabilizer. The shelf-life of 5X StabilCoat Immunoassay Stabilizer is 2 years when stored at 4C. Product ...
Biology Products: