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Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up
Date:7/31/2014

, MD said: "All the biologic drugs that we currently use for treating conditions such as psoriasis work by dampening down inflammation all over the body, not just in the skin where the disease occurs. As a result they all have general immunosuppressive side-effects such as increases in number and severity of infections."

The peptides are derived from the plasma protein chemerin and work by reducing the production of inflammatory signaling proteins called cytokines which play a central role in the body's response to infection and injury. They are also implicated in the excessive immune responses underlying inflammatory diseases. The peptides inhibit activated antigen presenting cells by reducing the production of inflammatory cytokines including IL-12/23, TNFalpha, RANTES, IL-6 and IL-1beta.

Isis has granted Rogne an exclusive, world-wide licence to the associated patents.

The initial work in Professor Greaves' lab investigating inflammation was funded by the British Heart Foundation in the context of possible novel anti-inflammatory treatments for cardiovascular disease.  Professor Jeremy Pearson, Associate Medical Director at the Foundation, said: "We are delighted that the research we funded has now led to a potential new anti-inflammatory treatment for psoriasis."

Media enquiries:
Renate Krelle
Isis Innovation Ltd
renate.krelle@isis.ox.ac.uk
T: +44(0)1865280867

Lena Wu
Rogne Bioscience, Inc.
info@rognebioscience.com

About Isis Innovation

Isis Innovation is the research and technology commercialisation company of the University of Oxford. We provide access to technology from Oxford researchers through intellectual property licensing, spin-out company formation and material sales, and to academi
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SOURCE Rogne Bioscience, Inc.; Isis Innovation Ltd
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