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Oxford licenses anti-inflammatory peptides to San Francisco Bay Area start-up
Date:7/31/2014

PORTOLA VALLEY, Calif., July 31, 2014 /PRNewswire/ -- Rogne Bioscience, a privately-held biotechnology company based in San Francisco Bay Area, has acquired a licence to anti-inflammatory peptides from Isis Innovation, the University of Oxford's commercialisation company. The potent anti-inflammatory activity of the peptides was discovered by Professor David Greaves at the University of Oxford's Sir William Dunn School of Pathology.

The company, which has raised over $1.5 million in seed financing, is developing a first-in-class, topical biologic to address the unmet need for a safe, effective, non-steroidal treatment for patients with mild to moderate psoriasis.

Tom Gadek, CEO of Rogne, said: "In Rogne's feasibility studies, we have been able to verify the anti-inflammatory activity of the peptide that was first published by Professor Greaves' lab. We have also demonstrated that the peptide can be formulated to penetrate human skin and, when applied topically, inhibits dermal inflammation in a dose-dependent manner in mice. We plan to complete a clinical proof of concept study to demonstrate activity in psoriasis patients."

Professor Greaves said: "Because the peptide will be applied to the skin, we expect to avoid the side-effects which trouble patients who use current injected or oral psoriasis drugs.

"Our peptide is also derived from a protein which is produced naturally by the human body and appears to play a role as the body's own off-switch for inflammation. 

"It's been really great that Isis Innovation have worked with us over the last five years to ensure that these important early steps in reaching the potential of this discovery have happened. We are also delighted to be working with Rogne Bioscience."

Rogne's Chief Medical Officer, Karl Beutner
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SOURCE Rogne Bioscience, Inc.; Isis Innovation Ltd
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