Navigation Links
OncoGenex Pharmaceuticals Announces OGX-427 Treatment Demonstrates Safety, Evidence of Declines in Circulating Tumor Cells and Reductions in Tumor Markers in a Phase 1 Cancer Trial
Date:5/30/2009

not met at the highest dose evaluated as monotherapy (1000 mg). - No evidence of altered cardiac activity was observed. - Majority of adverse events were mild and mainly occurred during the loading doses. Adverse events consisted of chills, itching and fatigue in over a third of patients. - There was a trend for increasing incidence of some mild adverse events with escalating OGX-427 doses. For example, 33% of patients at the 200-mg dose compared to 67% of patients at the 1000-mg dose had mild adverse events during the loading doses. - The half-life of OGX-427 in the blood remained constant, although there appeared to be an increase in maximum blood levels and a corresponding decease in blood clearance of OGX-427 as doses were escalated.

The combination of 800 mg OGX-427 with docetaxel was also well tolerated and escalation to 1000 mg OGX-427 with docetaxel will be evaluated next.

Circulating Tumor Cell and Tumor Marker Results

Circulating tumor cells (CTCs), an emerging metric to assess treatment effect, was evaluated at baseline before treatment and during treatment. Both total and Hsp27-positive CTCs were evaluated. Declines of 50% or greater in both total and Hsp27-positive CTCs were observed in over half of the patients in each cohort and in each cancer category. Declines in Hsp27 CTCs to 5 or less cells occurred in 27% of patients who had greater than 5 CTCs at baseline.

Reduction in tumor markers defined as declines of PSA levels in prostate cancer or CA-125 levels in ovarian cancer were also observed. A reduction in PSA level was observed in 7 of 20 patients (35%) with prostate cancer and a reduction in CA-125 levels was observed in 3 of 5 patients (60%) with ovarian cancer.

"CTCs are emerging as an exciting surrogate of anti-cancer activity. The frequent decreases in total
'/>"/>

SOURCE OncoGenex Pharmaceuticals, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4 5

Related biology technology :

1. OncoGenex Pharmaceuticals to Webcast ASCO Reception on May 30, 2009
2. OncoGenex Pharmaceuticals Announces Release of Two ASCO Abstracts: Impact of OGX-011 on Survival in Randomized Phase 2 Trial and Phase 1 Safety Data for OGX-427
3. OncoGenex Pharmaceuticals Clinical Programs to be Featured in Oral Presentations at the American Society of Clinical Oncology Annual Meeting
4. OncoGenex Reports First Quarter Financial Results
5. OncoGenex Pharmaceuticals to Release First Quarter Financial Results
6. OncoGenex Receives Confirmation from FDA on the Design of a Second Phase 3 Trial Evaluating OGX-011 for the Treatment of Advanced Prostate Cancer
7. OncoGenex Pharmaceuticals Named Life Sciences Company of the Year by LifeSciences British Columbia
8. OncoGenex Reports Financial Results for Fourth Quarter and Fiscal Year 2008 and Provides Outlook for 2009
9. OncoGenex Pharmaceuticals to Webcast Financial Results for Fourth Quarter and Fiscal Year 2008 and Provide Outlook for 2009
10. OncoGenex Provides Update on Two-Year Survival Data from Ongoing Phase 1/2 Clinical Trial of OGX-011 in Non-Small Cell Lung Cancer
11. OncoGenex To Present At The RBC Capital Markets 2008 Healthcare Conference
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2015)... LONDON , May 6, 2015 /PRNewswire/ ... clean fuel membrane specialist, announced today that it has ... based Pacific Ethanol, Inc. (Nasdaq: PEIX ) for the ... is to reduce the consumption of water, ... ethanol while  increasing product output. This project ...
(Date:5/6/2015)... 2015 Dr Jaspreet Singh , Senior ... deliver a speech at the 2015 Asian Starch Conference, to ... Expo Center.  , ... the topic: ,Potato Starch: A Potential Source for the ... Co-editor of a 528 page text book entitled ...
(Date:5/5/2015)... May 05, 2015 RURO, Inc., a ... FreezerPro® version 7, the latest major content upgrade to ... Upgrade is a significant advancement of ... in enhancing users experience, while also simplifying , ... system requirements , Download available immediately for ...
(Date:5/5/2015)... - Aptose Biosciences Inc. (NASDAQ: APTO, TSX: APS) ("Aptose" or ... months ended March 31, 2015 and provided a corporate ... dollars. Effective July 17, 2014 the ... to December 31. As a result of that change, ... three months ended March 31, 2015, while the prior ...
Breaking Biology Technology:Whitefox Signs Agreement With Pacific Ethanol Inc. 2Potato Starch: A Potential Source for the Creation of Next Generation Bulk-ingredients and Smart Foods 2RURO Releases version 7 of FreezerPro® software 2Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 2Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 3Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 4Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 5Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 6Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 7Aptose Biosciences Reports Results for the First Quarter Ended March 31, 2015 8
... Other important parameters for optimizing electroporation., , , , , , , ... , Pulse length , , ... Adjustment , of the electroporation buffer , ... Influence , of temperature , Influence , ...
... , , , , , , Other important parameters for optimizing electroporation., , ... Field strength , , Pulse ... field pulses , Adjustment , ... of DNA/RNA , Influence , ...
... , and the Brinkmann Bottletop Buret ... , , Bottletop dispensers are used in the ... solvents from glass or stainless steel containers. These dispensers , ... , substances which may disturb trace analysis, have cytotoxic ...
Cached Biology Technology:Optimizing electroporation parameters 2Optimizing electroporation parameters 3Optimizing electroporation parameters 4Optimizing electroporation parameters 5Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 2Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 3Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 4Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 5Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 6Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 7Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 8Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 9Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 10Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 11Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 12Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 13Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 14Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 15Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 16Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 17Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 18Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 19Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 20Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 21Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 22Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 23Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 24Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 25Chemical Stability of the Brinkmann Bottletop Dispenser , and the Brinkmann Bottletop Buret 26
(Date:4/14/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces that its Wocket® ... York Design Awards under the category  ,Product Design – ... Awards are part of a global multi-disciplinary awards program. ... the marketplace, industry and judging panel. Winners will be ...
(Date:4/9/2015)... , April 9, 2015 Synaptics Inc. (NASDAQ: ... announced today that it will report financial results for ... 23, 2015, after the close of market. The company ... investors at 2:00 p.m. PT (5:00 p.m. ET), during ... To participate on the live call, analysts and investors ...
(Date:4/2/2015)... At its 2015 ACMG Annual Clinical Genetics ... the American College of Medical Genetics and Genomics (ACMG) ... Board.  Members of the ACMG Board of Directors serve ... advancing its policies and programs. ACMG is the national ... an eventful time in medical genetics and genomics.  We ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3Synaptics to Report Third Quarter Results on April 23 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 2American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 3American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 4American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 5American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 6American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 7American College of Medical Genetics and Genomics Announces New Board Members: Dr. Louanne Hudgins is ACMG President-Elect 8
... with a probiotic strain of E. coli bacteria could help ... infection that may be associated with Crohn,s disease. Researchrs ... in the April 2011 issue of the journal Applied and ... that affects the gastrointestinal tract and is believed to develop ...
... In what could be a potential breakthrough in the ... design of new drugs, scientists have engineered a new protein ... based on a naturally occurring protein in the body that ... cause inflammation and other side effects at the dosages needed ...
... Reducing Emissions from Deforestation and Forest Degradation ,Plus, ... aims to financially compensate landowners and stewards for ... promoting forest conservation, sustainable forest management and the ... implemented correctly, REDD+ has the potential to generate ...
Cached Biology News:Intelligent design: Engineered protein fragment blocks the AIDS virus from entering cells 2REDD+, Technical, Socioeconomic and Political Dimensions 2REDD+, Technical, Socioeconomic and Political Dimensions 3
... is a simple high performance method for ... detergents without significant dilution of protein solution. ... the Detergent-OUT Spin column and collect detergent ... is suitable for removing detergents from a ...
... derived from frozen embedded tissue blocks, which ... to ensure the highest quality. Tissues of ... block, sectioned at a thickness of 7 ... are large (3-5 mm in diameter) in ...
... Zyagen tissue microarrays are derived from Paraffin ... rigorous quality control procedures to ensure the ... manually assembled in one block, sectioned at ... on coated slides. Sections are large (3-5 ...
... Zyagen tissue microarrays are derived from ... to rigorous quality control procedures to ensure ... are manually assembled in one block, sectioned ... on coated slides. Sections are large (3-5mm ...
Biology Products: