1. A method for treating a glioma in a mammal, the method comprising:
(a) administering at least one vaccination of dendritic cells ("DC") to said mammal suffering from a glioma, wherein the [sic] at least one vaccination of DC comprises autologous DC that present autologous glioma antigens;
(b) after glioma recurrence following (a), administering a regimen of chemotherapy to said mammal, wherein said regimen of chemotherapy includes the administration of at least one chemotherapeutic agent selected from the group consisting of temozolomide, procarbazine, vincristine, BCNU, CCNU, thalidomide, irinotecan, isotretinoin, imatinib, etoposide, and combinations thereof.
Thus, this patent claim only covers situations where the method of treatment used includes BOTH steps (a) AND (b).
Furthermore, to be within the scope of the '090 patent, it is not even enough to do both steps (a) and (b)….. the steps must be performed in a precise sequence, and they must straddle the timing of the recurrence of the glioma tumor. Step (a), the dendritic cell vaccination, must occur first and specifically be before the tumor recurrence, and step (b) must follow step (a) and specifically be after the tumor recurrence. The '090 patent is limited to this precise sequence and timing.
Cedars Sinai/IMUC tried
|SOURCE Northwest Biotherapeutics|
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