Navigation Links
Northern Antibiotics Presents New Data on Novel Polymyxin Compounds at the Joint ICAAC/IDSA 2008
Date:10/28/2008

us in vitro findings.

The pharmacokinetic studies, performed in Sprague-Dawley rats, showed that the serum half-lives of NAB739 and NAB7061 were close to that of colistin. However, both NAB compounds had much greater renal clearance and much higher urinary recovery than observed for colistin. Accordingly, and in contrast to colistin and polymyxin B, the NAB compounds are excreted into urine to a significant extent. This indicates that the reuptake of the NAB compounds in the proximal tubuli of the kidneys is less intense than that of colistin and polymyxin B.

The extensive reuptake is regarded to be the mechanism of the nephrotoxicity of polymyxins. Thus the reported findings suggest that NAB739 and NAB7061 are less nephrotoxic than colistin and polymyxin B. They are also in line with the previous finding (Vaara M. et al., 2008) that the affinities of NAB739 and NAB7061 for isolated rat kidney brush border membrane are significantly lower than that of polymyxin B.

These two studies were presented in the Poster Session #290 on Tuesday, October 28, 2008, 11:15 AM -12:15 PM.

Poster F1-3966: "Novel Polymyxin Derivatives are Effective in Treating Peritoneal E.coli Infection in Mice", C. VINGSBO LUNDBERG 1, T. VAARA 2, N. FRIMODT-M0LLER 1, M. VAARA 2; 1Statens Serum Inst., Copenhagen, Denmark, 2Northern Antibiotics Ltd, Helsinki, Finland

Poster FI-3997: "Pharmacokinetics (PK) of Novel Anti-Gram-negative (G-) Antibiotics in Rats", F. E. A. ALI 1, G. CAO 1, A. POUDYAL 1, T. VAARA 2, R. L. NATION 1, M. VAARA 2, J. LI 1; 1Facility for Anti-infective Drug Dev. & Innovation, Monash Univ., Melbourne, Australia, 2Northern Antibiotics Ltd, Helsinki, Finland

Professor Martti Vaara, CEO and co-founder of Northern Antibiotics Ltd., commented, "Multidrug-resistant enteric bacteria are emerging at an alarming rate. This is a serious concern, since enteric bacteria are responsible for more than 80% of all the hospital infections caused by Gram-n
'/>"/>

SOURCE Northern Antibiotics Ltd
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3

Related biology technology :

1. GlaxoSmithKline and Anacor Pharmaceuticals Form Alliance to Develop Systemic Antivirals and Antibiotics Based on Boron Chemistry
2. Drugs from Johnson & Johnson/Basilea and Forest Are the Most Promising Antibiotics in the Community-Acquired Pneumonia Pipeline
3. Solving the Z rings mysteries may lead to new antibiotics
4. Skin & Aging Article Finds Derma Sciences MEDIHONEY(TM) Helps to Promote Healing Where Antibiotics Fail
5. Nektar Receives Patent Covering Pulmonary Targeted Antibiotics
6. Trius Awarded $28 Million Contract to Develop Novel Antibiotics
7. Lexicon Presents Class of Compounds Modulating TPH1, the Target for its LX1031 Investigational Drug for Irritable Bowel Syndrome
8. Touching 418 Billion Lives, Hepatitis Still Presents Significant Threat to Global Health
9. Touching 418 Million Lives, Hepatitis Still Presents Significant Threat to Global Health
10. Nektar Presents Positive Results from Phase 1 Clinical Trial of NKTR-118 (oral PEG-naloxol) at American College of Clinical Pharmacology Meeting
11. Sangamo BioSciences Presents Data Demonstrating In Vivo Protection Against HIV Infection by CCR5-ZFN Therapeutic
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2015)... September 1, 2015 Shire plc (LSE: ... Sara Mathew to its Board of Directors as a ... Audit, Compliance & Risk Committee of the Shire Board. Both ... Sara previously served as Chairman, President and Chief Executive ... 2013. During her 12-year tenure at D&B, she helped drive ...
(Date:8/31/2015)... ... 31, 2015 , ... In recent years, biodegradable plastics have ... carbon footprints and compostability. These properties can help in limiting the degradation of ... of applications, the market for biodegradable plastics can be broadly segmented into packaging, ...
(Date:8/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/k6lcp2/mexico_biomedical ) has ... Market - Growth, Trends & Forecasts (2014-2020)" report ... Biomedical Sensors market is estimated at $0.20 billion by ... 2014-2020 The near future will bring biomedical ... each individual. These sensors can be set to trigger ...
(Date:8/31/2015)...  For people with Down syndrome, news from ... company, located in the Science + Technology Park at ... therapies yet for people with Down syndrome and other chromosome ... syndrome and Edwards syndrome aneuploidies in human cell cultures, ... Elixirgen plans to develop this technology into a treatment ...
Breaking Biology Technology:Shire Appoints Sara Mathew to Board of Directors 2Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 2Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 4Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 5Mexico Biomedical Sensors Market Report 2015-2020 2New Down syndrome therapy discovered 2
... Blindness in the UK(1) Though ... Factors Remains Low, WALTON OAKS, England, October 9 ... of the eye disease glaucoma. It,is estimated that there are ... at risk of losing their sight due to undiagnosed glaucoma(2),despite ...
... to Pathwork Following FDA ... Clearance and $20M Fundraising Round, SUNNYVALE, Calif., Oct. ... announced today the,appointment of two key positions within the company,s ... as Vice,President of US Sales. These professionals bring over 20 ...
... battle with heart disease that included numerous medications, trips to the emergency ... in the Intensive Care Unit at an Ohio hospital. Both sides of ... transplant. , ... TUCSON, Ariz. (Business Wire EON) October 8, 2008 ...
Cached Biology Technology:World Sight Day - Britons at Risk of Losing Their Sight by Not Having Regular Eye Tests 2World Sight Day - Britons at Risk of Losing Their Sight by Not Having Regular Eye Tests 3World Sight Day - Britons at Risk of Losing Their Sight by Not Having Regular Eye Tests 4World Sight Day - Britons at Risk of Losing Their Sight by Not Having Regular Eye Tests 5Pathwork Diagnostics Announces Key Additions to Management Team 2 "Put Down the BBQ Ribs, We've Found You a Donor Heart," Nurse Tells Patient : Ohio Father near Death Gets Second Chance at Life with CardioWest™ temporary Total Artificial Heart 2
(Date:8/6/2015)... Germany , August 6, 2015 ... Instruments (SMI) shows the world,s first Eye ... on Epson,s Moverio BT-200 see-through head mounted display and ... solution, unprecedented quality and efficiency is brought to personalized ... For the first time, professionals and researchers can integrate ...
(Date:8/4/2015)... 04, 2015 ... announced the addition of the "Digital ... Service), Sub-Segment (Computer Forensics, Network Forensics, Mobile ... Service, Vertical and Region - Global Forecast ... By Component (Hardware, Software, and ...
(Date:7/31/2015)... julho de 2015 A 10 a. ... realizada pela BGI de 22-25 de outubro de 2015, em ... A conferência está celebrando seu 10 o. aniversário este ... tornou uma das reuniões mais influentes do mundo no ... dinâmicos, entusiastas e prazerosos. A ICG-10 ...
Breaking Biology News(10 mins):SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3
... both bring a combination of individual scientific skills, ... together, these offer the opportunity to build a ... will address the urgent need for bringing new ... discovery, antibiotics and other antimicrobial agents have saved ...
... public health concern in Africa and a potential biological ... Due to its virulent nature, and because no ... have had to work under the most stringent biocontainment ... and hampering the ability of scientists to develop countermeasures. ...
... genes involved in Lupus, a devastating autoimmune disease, in ... In an international genetic study of more than ... Lupus (systemic lupus erythematosus or SLE) and mutations in ... scientists from Imperial College London and institutions in the ...
Cached Biology News:Unique fungal collection could hold key to future antibiotics 2Unique fungal collection could hold key to future antibiotics 3Ebola virus disarmed by excising a single gene 2Ebola virus disarmed by excising a single gene 3Genes linked with lupus are revealed, giving hope for new treatments 2Genes linked with lupus are revealed, giving hope for new treatments 3
... of the mitochondrial transmembrane potential ... intracellular events that occur following ... Apoptosis Detection Kit utilizes a ... as a mitochondrial activity marker. ...
The PDS-1000 He Hepta system includes the PDS-1000 He biolistic system and the Hepta adaptor....
... BioLogic LP system, 220-240 V, is ... fraction collection. The system includes the ... kit with MV-6 injection valve, proportioning ... cell, tubing and fittings kit, column ...
... been developed for affinity capture of ... of ProteinChip chemical surfaces allow differential ... unique biochemical properties. Each chip has ... comparison, and the chips are color-coded ...
Biology Products: