Navigation Links
Nile Therapeutics Announces Top-Line Results in Clinical Trial Evaluating the Subcutaneous Infusion of Cenderitide, Meets Primary Endpoint
Date:11/16/2011

SAN MATEO, Calif., Nov. 16, 2011 /PRNewswire/ -- Nile Therapeutics, Inc. (OTCQB: NLTX), a biopharmaceutical company that develops novel therapeutics for heart failure patients, today announced top-line data from its recently completed Phase I clinical trial evaluating the pharmacokinetics (PK), pharmacodynamics (PD), safety and tolerability of subcutaneous bolus and subcutaneous infusion of cenderitide in patients with chronic heart failure. Nile is developing cenderitide as a 90-day outpatient treatment for heart failure patients following admission for acutely decompensated heart failure (ADHF), referred to as the "post-acute" treatment period.

The Phase I clinical trial was designed to understand the doses required to achieve pre-determined plasma levels of cenderitide when delivered through a subcutaneous infusion pump. The target cenderitide plasma levels were based on Nile's previous Phase 2 clinical trials in which cenderitide was delivered through continuous intravenous infusion. In Part A of the trial, 12 patients received two subcutaneous bolus injections of cenderitide.  In Part B of the trial, 34 patients received a 24-hour continuous subcutaneous infusion of either of two fixed doses of cenderitide or placebo. In Part C, 12 patients received a 24-hour continuous subcutaneous infusion of either a weight-based dose of cenderitide, or placebo. All infusions were delivered through subcutaneous pump technology of Medtronic, Inc. pursuant to the parties' February 2011 development collaboration agreement.

The top line results from the Phase 1 trial are as follows:

  • The primary end-point was met – cenderitide achieved target PK levels when delivered through Medtronic's subcutaneous pump technology;
  • 24 hour subcutaneous delivery of ceneritide through Medtronic's pump technology was well-tolerated, with no injection site irritation;
  • Subcutaneously delivered cenderitide has an acc
    '/>"/>

SOURCE Nile Therapeutics, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Nile Therapeutics Reports 2011 Third Quarter Financial Results
2. Cell Therapeutics, Inc. Reports Results of Annual Meeting of Shareholders
3. Orexigen® Therapeutics Reports Third Quarter Financial Results
4. Silence Therapeutics Provides Corporate and Development Update
5. Halozyme Therapeutics Reports Third Quarter 2011 Financial Results
6. Regado Biosciences, Inc. Presents Positive Efficacy and Safety Substudy Data from the Phase 2b RADAR Trial for the REG1 Anticoagulation System at the Transcatheter Cardiovascular Therapeutics (TCT) Symposium 2011
7. Karyopharm Therapeutics Closes $10 Million Series A2 Financing to Expand Planned Phase 1 Program of Oral Selective Inhibitors of Nuclear Export (SINE) for Cancer
8. Halozyme Therapeutics Announces Data From Two Phase 1 Studies of PEGPH20 Demonstrating Targeting of Hyaluronan in Tumor Stroma
9. United Therapeutics Corporation Reports Third Quarter 2011 Financial Results
10. Amsterdam Molecular Therapeutics Provides Operations Update & Strategic Review of Pipeline
11. Cell Therapeutics, Inc. (CTI) Reports Third Quarter Financial Results and Milestones
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... can go downhill fast when a patient has sepsis, ... in a patient,s blood -- often too fast for ... human spleen and developed by a team at Harvard,s ... the way doctors treat sepsis. , "Even with ... intensive care units at least 30 percent of the ...
(Date:9/15/2014)... 2014  iVinci Health LLC, the company behind the ... system, branded as VisitPay®, has successfully closed $5 million ... of a new extension to VisitPay® – an online ... convenient way for patients to manage their medical bills ... and their families. The new round of ...
(Date:9/15/2014)... 15 septembre 2014 La deuxième édition ... (semaine internationale sur la sensibilisation au plasma) ... conjointe de la Plasma Protein Therapeutics Association ... , l,IPAW vise à : , ... la collecte du plasma-aphérèse , Reconnaître la ...
(Date:9/14/2014)... regulate protein functions in a wide variety of ways, ... a protein can take on another form and perform ... that fold wrongly can cause serious diseases such as ... also have a tendency to "infect" other molecules of ... fibrils or plaques. These amyloids can damage cells and ...
Breaking Biology Technology:Blood-cleansing biospleen device developed for sepsis therapy 2Blood-cleansing biospleen device developed for sepsis therapy 3Blood-cleansing biospleen device developed for sepsis therapy 4iVinci Health Raises $5M to Fuel National Expansion, Announces Launch of Personal Finance Portal for Healthcare 2iVinci Health Raises $5M to Fuel National Expansion, Announces Launch of Personal Finance Portal for Healthcare 3L' International Plasma Awareness Week célébrera les donneurs et braquera les projecteurs sur les maladies rares 2L' International Plasma Awareness Week célébrera les donneurs et braquera les projecteurs sur les maladies rares 3Measuring modified protein structures 2Measuring modified protein structures 3
... On July 17th John Byrnes made the following statements in ... Its time to get serious. It is time to stop ... there is nothing we can do about it. These comments ... article and not come away with the impression that (1) ...
... In 1999, charities had raised only $7 million via the Internet, ... Last year, according to the Chronicle of Philanthropy, which now ... $124.5 million. , ,Charities and their for-profit partners are ... the Boys & Girls Club of Dane County and Trek Bicycles ...
... Six Spam Fighters Face Off in Madison , ... WiscNet were once again selected by eWeek, a weekly ... real-world test and evaluation partner for enterprise computing solutions. ... at a two-day Anti-Spam evaluation at the University of ...
Cached Biology Technology:Let's Get Serious About Manufacturing! 2Whos Starting to Profit Online? Nonprofits. 2Six Spam Fighters Face Off in Madison 2Six Spam Fighters Face Off in Madison 3Six Spam Fighters Face Off in Madison 4
(Date:9/15/2014)... mechanical solution to avoid chromosome sorting errors, researchers ... Express. , This natural safeguard prevents ... infertility, miscarriage, or congenital conditions. , "Mistakes ... what exactly goes wrong is often not understood," ... for Cell Biology at the University of Edinburgh ...
(Date:9/15/2014)... this week,s print issue of the journal Science ... from New Mexico, Montana and even the Netherlands, thanks ... and more the norm in these connected times. Yes, ... will produce innovations in biology, medicine, biotechnology and agriculture. ... scientist talked with that one, that one knew another ...
(Date:9/15/2014)... Sonja Schmid, an assistant professor in the Department of ... Liberal Arts and Human Sciences at Virginia Tech, has ... (CAREER) Award to study the prospects and problems of ... catastrophic failure of Japan,s Fukushima I Nuclear Power Plant ... the scientific community viewed nuclear emergencies, Schmid said. Three ...
Breaking Biology News(10 mins):Cells simply avoid chromosome confusion 2Cells simply avoid chromosome confusion 3Collaboration drives achievement in protein structure research 2'Nuclear disasters don't respect national boundaries' 2
... Ore. Athletes seeking a healthy performance weight should ... regimen in order to maintain muscle while still burning ... University researcher. The United States now has a ... of as untouched by the obesity crisis. Nationally, more ...
... MA -- Although human cells have an estimated 20,000 genes, only ... depending on the cell,s needs which can change by the ... researchers need tools that can manipulate their status on similarly short ... developed at MIT and the Broad Institute that can rapidly start ...
... scientists have identified causes of a rapid warming in ... partly attribute the observed warming, and preceding cooling trends ... emissions and aerosols predominantly generated in the Northern Hemisphere ... CSIRO and the University of NSW, was published today ...
Cached Biology News:Athletes need to be careful to monitor diet, weight to maintain muscle mass 2Athletes need to be careful to monitor diet, weight to maintain muscle mass 3Controlling genes with light 2Controlling genes with light 3Rapid upper ocean warming linked to declining aerosols 2
Newborn Bovine Serum Heat-Inactivated...
... MagicMark XP Western Protein Standards are ... protein molecular weight estimation directly on ... an IgG binding site, allowing direct ... used to detect your target protein ...
... is the most effective ... PCR products. TOPO TA ... TOPO vectors are supplied ... topoisomerase I. This enables ...
... Conjugated peptides or recombinant proteins are ... produce antibodies in 2 rabbits. pre-immune and ... test until the titer reaches 1:4,000 Western ... Protein G purification Antibodies are eluted using ...
Biology Products: