Navigation Links
NexBio(R) Demonstrates DAS181 (Fludase(R)*), a Broad-Spectrum Drug Candidate, Inhibits Influenza Viral Infection in Human Lung Tissue
Date:8/25/2009

SAN DIEGO, Aug. 25 /PRNewswire/ -- NexBio, Inc. announced today the publication "DAS181 Inhibits H5N1 Influenza Lung Virus Infection of Human Lung Tissues" in the September, 2009 issue of the journal Antimicrobial Agents and Chemotherapy (AAC).

DAS181 (Fludase((R))) is an investigational drug candidate in clinical development for Influenza-Like Illness. Unlike neuraminidase inhibitors (e.g. Tamiflu((R))), which target the virus, DAS181 works by inactivating the human host receptor for all influenza and para-influenza viruses tested so far including the current pandemic Novel H1N1 strain ("Swine Flu"). Previous preclinical studies conducted in collaboration with the Centers for Disease Control and Prevention have shown DAS181 to have significant prophylactic and therapeutic activity in an in vivo animal model for a highly virulent H5N1 (A/VN/1203/04) strain of influenza. The current published study, conducted in collaboration with the University of Hong Kong, examined for the first time the effects of DAS181 in human lung tissue and cells. DAS181 strongly inhibited H5N1 (A/VN/3046/2004) infection in human lung tissue and cells. The study also demonstrated that DAS181 effectively removes the two types of sialic acid (Sia) receptors to which influenza virus binds, thereby preventing both the invasion by virus into new cells and further replication where infection already exists.

The human lung tissue and cells described have been critical models for understanding the clinical pathogenesis of influenza, as people contain two types of receptors for influenza. While H5N1 preferentially binds to A2-3-linked Sia, Novel H1N1 preferentially binds to A2-6-linked Sia. DAS181 was shown in these studies to remove both the A2-6-linked and A2-3-linked types found in human respiratory tissue. Most importantly, virus was suppressed by inactivation of the entry receptors by DAS181 treatment.
'/>"/>

SOURCE NexBio, Inc.
Copyright©2009 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. Data Published in Cell Stem Cell Demonstrates Potent Anti-Cancer Activity for OncoMed Pharmaceuticals Lead Antibody
2. Abbott HIV Test Demonstrates Earlier Disease Detection
3. BioNeutrals Ygiene(TM) Hospital Grade Antimicrobial Demonstrates a 99.9997% Kill Rate Against Clostridium Difficile Spores (C.diff) in Independent Lab Pre-testing Phase
4. New Pre-Clinical Data on OmniGuides BeamPath NEURO(TM) Demonstrates Precise Cutting in Brain Tissue
5. Phase II Trial Demonstrates Elacytarabine May Increase Survival Threefold in Patients With Late-Stage Leukaemia
6. PROSTVAC(TM) Data Presented at the ASCO Meeting Demonstrates the Potential for Significant Increases in Life Expectancy in Late-Stage Prostate Cancer
7. NIMOTUZUMAB DEMONSTRATES EFFICACY IN RANDOMIZED HEAD & NECK CANCER STUDY WITHOUT THE TOXICITIES ASSOCIATED WITH OTHER EGFR DRUGS
8. OncoGenex Pharmaceuticals Announces OGX-427 Treatment Demonstrates Safety, Evidence of Declines in Circulating Tumor Cells and Reductions in Tumor Markers in a Phase 1 Cancer Trial
9. SemBioSys plant-derived Apo AI(Milano) demonstrates encouraging biologic activity in seven preclinical models
10. OrbusNeichs Genous(TM) Bio-engineered R stent(TM) Demonstrates Impressive Results in Higher Risk Patients
11. Finesse Demonstrates TruFluor(TM) pH, a Single-Use Optical pH Sensor and Transmitter
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... (PRWEB) September 23, 2014 Texas Fertility ... clinic in South Austin, expanding a Central Texas footprint ... San Antonio. The satellite office for the region’s most ... options to the South Austin, Buda, Kyle and San ... and affordable fertility treatment directly to individuals and couples ...
(Date:9/23/2014)... Albany, New York (PRWEB) September 23, 2014 ... advocates from around the globe will convene ... 11th International Conference, to be held October ... latest in evidence-based research and practice in ... includes physicians, scientists, researchers, nurses, psychologists, nutritionists, ...
(Date:9/22/2014)... OAKLAND, Calif., September 22, 2014 Patients who were treated ... a hemorrhagic stroke were significantly more likely to survive ... published today in JAMA Neurology . This study ... that the use of cholesterol-lowering statins can improve survival ... by a constriction or obstruction of a blood vessel ...
(Date:9/22/2014)... Research and Markets ( ... "Global Biotechnology Reagents Market 2014-2018" report ... Biotechnology reagents are chemical compounds or ... detect and examine another substance to provide a ... to prepare, collect, and examine specimens from the ...
Breaking Biology Technology:Opening Doors to a Family: Texas Fertility Center Announces Newest Fertility Clinic in South Austin 2Opening Doors to a Family: Texas Fertility Center Announces Newest Fertility Clinic in South Austin 3International Medical Experts to Discuss Latest Integrative Oncology Research and Its Translation to Personalized Clinical Care at 11th International Conference of SIO 2International Medical Experts to Discuss Latest Integrative Oncology Research and Its Translation to Personalized Clinical Care at 11th International Conference of SIO 3Statin use during hospitalization for hemorrhagic stroke associated with improved survival 2Global Biotechnology Reagents Market 2014-2018: Key Vendors are Agilent, BD Biosciences, Bio-Rad, F. Hoffmann-La Roche, Sigma-Aldrich and Thermo Fisher 2Global Biotechnology Reagents Market 2014-2018: Key Vendors are Agilent, BD Biosciences, Bio-Rad, F. Hoffmann-La Roche, Sigma-Aldrich and Thermo Fisher 3
... coffee chain Stone Creek Coffee went about ... tool to enhance customer relationships: the blog. , ,According ... the blog can bring Stone Creek Coffee an ability ... releases or other traditional forms of communications. The company ...
... of a paper machine is something to hear. The spray of pulp ... the sound of industry. , ,But it's not the only sound. , ... forward, walk down the line a bit at Stora Enso's ... and listen to the hum as it carries 33-ton reels down the ...
... Catalyst International, Inc., has appointed Michael Eleftheriou ... than 30 years of experience in the information technology ... he last served as president of its Systems Integration ... Asia, India, Mexico and the Middle East. , ,Since ...
Cached Biology Technology:Business blogs increase customer interactions 2Business blogs increase customer interactions 3Business blogs increase customer interactions 4Business blogs increase customer interactions 5Cutting-edge technology keeps papermaker rolling 2Cutting-edge technology keeps papermaker rolling 3Cutting-edge technology keeps papermaker rolling 4
(Date:9/23/2014)... consequences of removing infant chimpanzees from their mothers are ... of this type of early life experience. In a ... chimpanzees and concluded that those who were removed from ... as pets or performers are likely to show behavioral ... project, published today in the open-access journal PeerJ ...
(Date:9/22/2014)... New Haven, Conn. Yale University researchers are studying ... pulmonary fibrosis, a respiratory disease in which scars develop ... treatment uses a microRNA mimic, miR-29, which is delivered ... only blocked pulmonary fibrosis, it reversed fibrosis after ... in the journal EMBO Molecular Medicine . , ...
(Date:9/22/2014)... molecular cog in a plant,s biological clock one ... on temperature. , Transcription factors, or genetic switches, drive ... such as light, rain, soil quality, or even animals ... has isolated one, called FBH1, that reacts to temperature ... while in keeping it on a consistent track. , ...
Breaking Biology News(10 mins):Chimpanzees raised as pets or performers suffer long-term effects on their behavior 2Reversing the effects of pulmonary fibrosis 2Genetic switch regulates a plant's internal clock based on temperature 2
... been considered an exclusively human activity, but now at least ... for tomorrow. The finding also raises the intriguing possibility that, ... published today (22 February) in the journal Nature shows that ... by caching food. The birds are shown to have learned ...
... steak or chicken fillet every now and again could add ... shown for the first time that food enriched with natural ... processes of ageing. The concept has been demonstrated in worms ... human life and reduce the risk of cancer and other ...
... a visual display "shout" to get their point across, UC ... of their territory by sitting up on a tree trunk, ... throat pouch. They can spot a rival lizard up to ... UC Davis who is working with Judy Stamps, professor of ...
Cached Biology News:Birds found to plan for the future 2Meat and two neutrons -- the key to a longer life 2
... an aqueous solution that contains a purified ... a PBS buffer (phosphate buffered saline), pH ... not contain a preservative. StabilCoat Immunoassay ... dried protein components in immunoassays and can ...
...
... DeCypher combines enterprise-scale sequence analysis software with the ... analyses. With DeCypher, you can perform searches like ... vs NCBI NT database in under 6 days ... genomic DNA Use HMM analysis to ...
... microplate readers combines reagent dispensing with fluorescence, ... easy-to-use platform for the complete range of ... and adaptability of the Infinite 200 series ... monochromator (M200) or filter (F200) system and ...
Biology Products: