Navigation Links
New Software from SRI Speeds Development of Genome-Scale Models for Drug and Fuel Research
Date:1/24/2012

MENLO PARK, Calif., Jan. 24, 2012 /PRNewswire/ -- SRI International has introduced MetaFlux, a new software tool to substantially decrease the time required for researchers to construct genome-scale models of metabolic networks. Metabolic networks are the complete set of metabolic and physical processes that determine the physiological and biochemical properties of a cell.  Genome-scale models are used to predict cell growth rate, combinations of chemicals that can support cell growth, and which genes will cause cell death if they are inactivated.

The new MetaFlux functionality can be used to design drugs against disease-causing bacteria and metabolically engineer bacteria to make chemicals and fuels. It may also yield insights about growth of bacteria that cannot currently be grown in a laboratory.

MetaFlux software couples flux balance analysis (FBA), a mathematical method to analyze metabolism, with pathway databases that contain information about the network of interactions between proteins and small molecules that forms the biochemical factory of a cell.

"Genome-scale models are very time consuming to construct, because they require an exact description of the hundreds of biochemical reactions within a cell—and a single missing reaction can render a model nonfunctional," said Peter D. Karp, Ph.D., director, Bioinformatics Research Group, SRI International. "Our goals were to speed up the development of these models and allow a wider community of scientists to build them. SRI's Bioinformatics Research group has already developed two different FBA models using MetaFlux, each within one month of effort." 

Based on mixed integer linear programming, MetaFlux uses a multiple gap-filling method to accelerate the development of FBA models. This method generates the models directly from pathway/genome databases, which can be constructed, queried, and visualized using SRI's Pathway Tools software. MetaFlux can also sugges
'/>"/>

SOURCE SRI International
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Number of Ion Community Users Triples, Spurred by Open Access to DNA Sequencing Protocols and Analysis Software
2. Software Helps Research Facilities Meet New NIH Financial Conflict of Interest (FCOI) Requirements
3. Innovative MetaMorph® NX Software Shatters Barriers Between Researchers and Image Analysis Goals with Exclusive Visual Workflow
4. Galaxy DNA-analysis software is now available in the cloud
5. Nexcelom Bioscience to Distribute FCS Express 4 Cytometry Software with Cellometer Vision CBA Instruments
6. Glencoe Software and The Journal of Cell Biology Pioneer Publishing of Genome-Wide Screens
7. Molecular Devices Enables Intuitive Functionality at Your Fingertips on the Apple iPad with the Latest SoftMax Pro Software
8. Life Technologies Simplifies, Organizes and Speeds Analysis of Genomic Data Through Launch of New LifeScope Bioinformatics Software
9. PRA International Acquires Key Software Developer
10. Brainlab Announces FDA 510(k) Clearance for New HybridArc™ Software for Radiosurgery
11. Open-source software designed to minimize synthetic biology risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... July 2, 2015  Spherix Incorporated (Nasdaq: SPEX ... and monetization of intellectual property, today announced a litigation ... Incorporated v. Verizon Services Corp. et al. , Case ... the Eastern District of Virginia , ... 2015 interpreting certain key claims in favor of the ...
(Date:7/2/2015)... Memphis, TN (PRWEB) , ... July 02, 2015 ... ... in the development and manufacturing of surgical instruments in Orthopedics, announced today the ... orthopedic contract-manufacturing and the world's largest provider of surgical instruments to the Spine ...
(Date:7/1/2015)... Mass. , July 1, 2015   ... most frequently cited advantages of Otezla are its ... safety profile, as reported by surveyed rheumatologists. Otezla ... launched for the treatment of active psoriatic arthritis ... The current standard of care includes conventional oral ...
(Date:7/1/2015)... Calif. , July 1, 2015   ... on the development of groundbreaking drugs to treat ... announced today that Robert G. Miller , ... at Sutter Health,s California Pacific Medical Center in San ... ALS Association for $1.5 million to help fund ...
Breaking Biology Technology:Spherix Issues A Litigation Update 2Spherix Issues A Litigation Update 3In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 2In'Tech Medical Acquires Turner Medical to Become a World Leader in Orthopedic Contract-Manufacturing 3Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 2Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 2Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 3Investigator to Receive $1.5 Million Grant from the ALS Association to Help Fund Confirmatory Phase 2 Study of Neuraltus Pharmaceuticals' NP001 4
... , , , , ... stem cell based,technology of Cellonis Biotechnologies, Beijing, a Chinese research/medical,team ... 36 year old Norwegian,patient in a hospital in Beijing. The ... stem cells as well as cancer daughter,cells. The amazing outcome ...
... ... Club, the Daveys, the GLOBALS, ,and PM360 Pharma Choice Awards Programs. , ... (PRWEB) December 17, 2009 -- ... advertising and marketing awards programs honoring exceptional creative and interactive work. , , ,THE ...
... test to find undetected landmines. Students from the University ... when it comes into contact with chemicals leaked by buried ... solution that, when sprayed on to the ground, forms green ... say that the organism, which is cheap to produce, could ...
Cached Biology Technology:For the First Time, a Glioma ¨C Brain Cancer ¨C may be Eliminated by a Chinese Research/Medical Team, Using a Novel Stem Cell Based Therapy of Cellonis Biotech, Beijing 2For the First Time, a Glioma ¨C Brain Cancer ¨C may be Eliminated by a Chinese Research/Medical Team, Using a Novel Stem Cell Based Therapy of Cellonis Biotech, Beijing 3For the First Time, a Glioma ¨C Brain Cancer ¨C may be Eliminated by a Chinese Research/Medical Team, Using a Novel Stem Cell Based Therapy of Cellonis Biotech, Beijing 4Goble & Associates Creative Work Awarded at Advertising Industry Competitions 2Goble & Associates Creative Work Awarded at Advertising Industry Competitions 3Goble & Associates Creative Work Awarded at Advertising Industry Competitions 4
(Date:6/17/2015)... , Deutschland und GERMANTOWN, Maryland ... Investigator ®   Produktlinie mit DNA-Tests ... QIAGEN N.V. (NASDAQ: QGEN ; Frankfurt Prime Standard: ... neue STR-Testkits der Produktlinie Investigator ... in den Markt eingeführt. Die neuen Kits zur Erstellung ...
(Date:6/17/2015)... , June 17, 2015  Synaptics Inc. ... interface solutions, today announced that Xiaomi, one of ... Synaptics ® ClearPad ® family of ... driver integrated circuits (DDICs) for its latest smartphones, ... leveraging ClearPad for full in-cell display solutions and ...
(Date:6/16/2015)... 16, 2015 /CNW Telbec/ - handyem Inc. and ... the incorporation of handyem,s HPC-150 portable flow cytometer ... Mo-POD™. This unprecedented model of mobile laboratory platform ... the Pennsylvania Convention Center, ... th to 18 th 2015.  By ...
Breaking Biology News(10 mins):QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 4QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 5QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 6Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 3handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3
... that treatments targeting specific viral genes protected monkeys infected ... were protected even when therapeutics were administered one hour ... infections in laboratory or hospital settings. The research, ... Nature Medicine , was conducted by the U.S. ...
... Holt , a professor of plant physiology at the University ... film Avatar , will receive the Paul ... a distinguished scientist and educator" at a ceremony beginning at ... Garden, 230 Quail Gardens Drive, Encinitas, Calif. "This award ...
... New Compound May be Effective Against Chagas, Disease ... candidate against the deadly tropical infection, Chagas, disease say researchers ... 2010 issue of the journal Antimicrobial Agents and Chemotherapy ... parasite Trypanosoma cruzi and it affects approximately 18 ...
Cached Biology News:Novel 'antisense' therapies protect primates from lethal Ebola and Marburg viruses 2Novel 'antisense' therapies protect primates from lethal Ebola and Marburg viruses 3Tips from the journals of the American Society for Microbiology 2Tips from the journals of the American Society for Microbiology 3Tips from the journals of the American Society for Microbiology 4
ExonBio Service provides one-stop recobinant protein shopping from cloning, expression and purification. Price including gene cloning....
... 75 x 25 mm; ... recommended for immunohistochemistry of paraffin-embedded sections, ... end, markings will not ... precleaned, ...
Donor feline serum and plasma...
8 different frozen tissues are mounted on positively charged glass slides...
Biology Products: