Navigation Links
New Software from SRI Speeds Development of Genome-Scale Models for Drug and Fuel Research
Date:1/24/2012

MENLO PARK, Calif., Jan. 24, 2012 /PRNewswire/ -- SRI International has introduced MetaFlux, a new software tool to substantially decrease the time required for researchers to construct genome-scale models of metabolic networks. Metabolic networks are the complete set of metabolic and physical processes that determine the physiological and biochemical properties of a cell.  Genome-scale models are used to predict cell growth rate, combinations of chemicals that can support cell growth, and which genes will cause cell death if they are inactivated.

The new MetaFlux functionality can be used to design drugs against disease-causing bacteria and metabolically engineer bacteria to make chemicals and fuels. It may also yield insights about growth of bacteria that cannot currently be grown in a laboratory.

MetaFlux software couples flux balance analysis (FBA), a mathematical method to analyze metabolism, with pathway databases that contain information about the network of interactions between proteins and small molecules that forms the biochemical factory of a cell.

"Genome-scale models are very time consuming to construct, because they require an exact description of the hundreds of biochemical reactions within a cell—and a single missing reaction can render a model nonfunctional," said Peter D. Karp, Ph.D., director, Bioinformatics Research Group, SRI International. "Our goals were to speed up the development of these models and allow a wider community of scientists to build them. SRI's Bioinformatics Research group has already developed two different FBA models using MetaFlux, each within one month of effort." 

Based on mixed integer linear programming, MetaFlux uses a multiple gap-filling method to accelerate the development of FBA models. This method generates the models directly from pathway/genome databases, which can be constructed, queried, and visualized using SRI's Pathway Tools software. MetaFlux can also sugges
'/>"/>

SOURCE SRI International
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Number of Ion Community Users Triples, Spurred by Open Access to DNA Sequencing Protocols and Analysis Software
2. Software Helps Research Facilities Meet New NIH Financial Conflict of Interest (FCOI) Requirements
3. Innovative MetaMorph® NX Software Shatters Barriers Between Researchers and Image Analysis Goals with Exclusive Visual Workflow
4. Galaxy DNA-analysis software is now available in the cloud
5. Nexcelom Bioscience to Distribute FCS Express 4 Cytometry Software with Cellometer Vision CBA Instruments
6. Glencoe Software and The Journal of Cell Biology Pioneer Publishing of Genome-Wide Screens
7. Molecular Devices Enables Intuitive Functionality at Your Fingertips on the Apple iPad with the Latest SoftMax Pro Software
8. Life Technologies Simplifies, Organizes and Speeds Analysis of Genomic Data Through Launch of New LifeScope Bioinformatics Software
9. PRA International Acquires Key Software Developer
10. Brainlab Announces FDA 510(k) Clearance for New HybridArc™ Software for Radiosurgery
11. Open-source software designed to minimize synthetic biology risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2015)... , Feb. 27, 2015  Pfenex Inc. (NYSE MKT: ... of biosimilar therapeutics, today announced that it will be ... Marquis on March 2 nd at 3pm PST. Patrick ... a panel discussing the current state of the biosimilar ... . For more information on CALBIO ...
(Date:2/27/2015)... Feb. 27, 2015  Steep Hill, the industry leader ... internationally, intends to open a full service medical cannabis ... , bringing advanced scientific tools and methodology to ... Steep Hill is currently the only laboratory licensed by ... and contaminant testing in order to meet the recently ...
(Date:2/26/2015)... On behalf of biotech client GenScript ... Goldman & Spitzer, P.A. (Wilentz) secured a significant jury ... in excess of $10 million. The jury determined that ... that it improperly hired one or more of GenScript,s ... judgment notwithstanding the verdict, a new trial, and remittitur. ...
(Date:2/26/2015)... LEXINGTON, Mass., Feb. 26, 2015   Synageva ... a biopharmaceutical company developing therapeutic products for rare ... and provided 2015 goals, other key objectives, and ... conference call today at 4:30 p.m. EST to ... business update.  To participate in today,s call by ...
Breaking Biology Technology:Steep Hill First to Receive Provisional Approval to Establish Laboratory Services for Cannabis Testing in State of New Mexico 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 2Wilentz Client GenScript Awarded $10 Million in Trade Secrets Case Against Genewiz 3Synageva BioPharma Reports 2014 Full Year Financial Results 2Synageva BioPharma Reports 2014 Full Year Financial Results 3Synageva BioPharma Reports 2014 Full Year Financial Results 4Synageva BioPharma Reports 2014 Full Year Financial Results 5Synageva BioPharma Reports 2014 Full Year Financial Results 6Synageva BioPharma Reports 2014 Full Year Financial Results 7Synageva BioPharma Reports 2014 Full Year Financial Results 8Synageva BioPharma Reports 2014 Full Year Financial Results 9
... reporter cell lines for signal transduction pathway readout ... Alan Greener Mary Buchanan ,John Bauer Chao-Feng ... ,HLR-CREB, HLR-Elk1, and HLR-cJun, cell lines ... that converge at the transcription,factors CREB, Elk1, and c-Jun. ...
... to imitate neurodegeneration , , Rob D. Dickerman ... Walter J. McConathy a,b , a Department of ... Texas Health Science Center , , This article describes ... system cells (hNT Neurons) to imitate the,aging human brain, ...
... high-titer efficiency and larger insert,potential , ... Libraries , Katherine Felts Kim Zaharee ... Peter Vaillancourt ,Stratagene , We introduce ... inserted into the,high-titer retroviral vector pFB. ViraPort ...
Cached Biology Technology:Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 2Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 3Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 4Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 5Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion,Transactivators 6Sex Steroid Regulation of Vasopressin Levels Secreted by hNT Neurons* 2Sex Steroid Regulation of Vasopressin Levels Secreted by hNT Neurons* 3Sex Steroid Regulation of Vasopressin Levels Secreted by hNT Neurons* 4Sex Steroid Regulation of Vasopressin Levels Secreted by hNT Neurons* 5Sex Steroid Regulation of Vasopressin Levels Secreted by hNT Neurons* 6Sex Steroid Regulation of Vasopressin Levels Secreted by hNT Neurons* 7Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 2Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 3Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 4Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 5Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 6Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 7Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 8Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 9Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 10Functional Cloning Using,ViraPort Retroviral cDNA Expression Libraries 11
(Date:2/19/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/kx9zp8/military ) ... Electro-Optical / Infrared Systems Market by Type, by ... to 2020" report to their offering. ... expected to reach $16.35 billion by 2020, to ... report segments the military electro-optical/infrared systems market on ...
(Date:2/11/2015)... February 11, 2015 ... "Access Control Market by Product (Cards and Readers, Biometrics, ... Defense, Government, Industrial, Healthcare, Education) and By Geography - Global ... MarketsandMarkets, the Access Control Market is expected ... at a CAGR of 10.6% between 2014 ...
(Date:2/5/2015)... 26, 2015   Epic Sciences , a precision diagnostics ... that Murali Prahalad , Ph.D., president and CEO, is ... (PMWC) 2015: Silicon Valley, which is taking place at ... on January 26-28, 2015. Dr. ... as Biomarkers." Last year, Epic Sciences was a finalist in ...
Breaking Biology News(10 mins):Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 2Military Electro-Optical / Infrared Systems (Image Intensification, Laser, Infrared) Market - Forecast to 2020: Featuring Profiles of the Market Leaders on this $16 Billion market 3Access Control Market Worth $10.4 Billion by 2020 2Access Control Market Worth $10.4 Billion by 2020 3Access Control Market Worth $10.4 Billion by 2020 4Epic Sciences to Present at Personalized Medicine World Conference 2015 on the Use of Circulating Tumor Cells as Cancer Biomarkers 2
... A. Wells, professor and chairman of the department pharmaceutical ... director of UCSF,s small molecule discovery center, has been ... Biochemistry and Molecular Biology-Merck Award for his pioneering studies ... who also serves on the ASBMB Council, will present ...
... technological innovation with business collaboration to improve conditions for ... new Hunter and Stephanie Hunt Institute for Engineering and ... Gifts totaling $5 million from Hunter and ... B. Lyle and others will establish the institute and ...
... Scientists have designed a synthetic protein that is ... of a native protein, nitric-oxide reductase. , The ... studying nitric-oxide reductase, and for creating biocatalysts for ... Illinois chemistry professor Yi Lu, who directed the ...
Cached Biology News:University of California, San Francisco, researcher receives ASBMB-Merck Award 2New engineering institute to modify, develop technology for the global poor 2New engineering institute to modify, develop technology for the global poor 3Synthetic protein mimics structure, function of metalloprotein in nature 2
Because it is manufactured at our ISO 9001–certified facilities in Eugene, Oregon, we can guarantee that FluoroPure Grade DAPI is greater than or equal to 98% pure by HPLC....
... Smith et.al. (1997) • Contains ... current biochemistry & molecular biology, ... headwords. Entries give details of ... in which they are involved ...
... • This book describes the basic ... preparing samples for protein transfer and ... bioluminescence-enhanced detection systems are also included. ... and characterization of glycoprotein carbohydrate chains ...
... Walker (1996) • This book offers ... studying proteins and peptides. Each tried ... instruction, timesaving troubleshooting tips, alternative procedures, ... reagents and suppliers. Topics covered range ...
Biology Products: