Navigation Links
New Software from SRI Speeds Development of Genome-Scale Models for Drug and Fuel Research
Date:1/24/2012

MENLO PARK, Calif., Jan. 24, 2012 /PRNewswire/ -- SRI International has introduced MetaFlux, a new software tool to substantially decrease the time required for researchers to construct genome-scale models of metabolic networks. Metabolic networks are the complete set of metabolic and physical processes that determine the physiological and biochemical properties of a cell.  Genome-scale models are used to predict cell growth rate, combinations of chemicals that can support cell growth, and which genes will cause cell death if they are inactivated.

The new MetaFlux functionality can be used to design drugs against disease-causing bacteria and metabolically engineer bacteria to make chemicals and fuels. It may also yield insights about growth of bacteria that cannot currently be grown in a laboratory.

MetaFlux software couples flux balance analysis (FBA), a mathematical method to analyze metabolism, with pathway databases that contain information about the network of interactions between proteins and small molecules that forms the biochemical factory of a cell.

"Genome-scale models are very time consuming to construct, because they require an exact description of the hundreds of biochemical reactions within a cell—and a single missing reaction can render a model nonfunctional," said Peter D. Karp, Ph.D., director, Bioinformatics Research Group, SRI International. "Our goals were to speed up the development of these models and allow a wider community of scientists to build them. SRI's Bioinformatics Research group has already developed two different FBA models using MetaFlux, each within one month of effort." 

Based on mixed integer linear programming, MetaFlux uses a multiple gap-filling method to accelerate the development of FBA models. This method generates the models directly from pathway/genome databases, which can be constructed, queried, and visualized using SRI's Pathway Tools software. MetaFlux can also sugges
'/>"/>

SOURCE SRI International
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Number of Ion Community Users Triples, Spurred by Open Access to DNA Sequencing Protocols and Analysis Software
2. Software Helps Research Facilities Meet New NIH Financial Conflict of Interest (FCOI) Requirements
3. Innovative MetaMorph® NX Software Shatters Barriers Between Researchers and Image Analysis Goals with Exclusive Visual Workflow
4. Galaxy DNA-analysis software is now available in the cloud
5. Nexcelom Bioscience to Distribute FCS Express 4 Cytometry Software with Cellometer Vision CBA Instruments
6. Glencoe Software and The Journal of Cell Biology Pioneer Publishing of Genome-Wide Screens
7. Molecular Devices Enables Intuitive Functionality at Your Fingertips on the Apple iPad with the Latest SoftMax Pro Software
8. Life Technologies Simplifies, Organizes and Speeds Analysis of Genomic Data Through Launch of New LifeScope Bioinformatics Software
9. PRA International Acquires Key Software Developer
10. Brainlab Announces FDA 510(k) Clearance for New HybridArc™ Software for Radiosurgery
11. Open-source software designed to minimize synthetic biology risks
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)...  RegeneRx Biopharmaceuticals, Inc. (OTCBB: RGRX) ("the Company" or ... International Symposium on Thymosins in Health and Disease in ... "When thymosin beta 4 (TB4) linked with rhodamine (a ... in a rodent model of stroke, it was visualized ... (the functional tissue of the brain).   The leakage of ...
(Date:10/22/2014)... 2014 New test innovations will be the ... (IVD) test industry, especially as companies struggle with reimbursement ... more than 25 testing innovations in important disease areas ... IVD products. Kalorama details the new approaches its biennial survey ... In Vitro Diagnostic Tests , 9th Edition . ...
(Date:10/22/2014)... The North American crystal oscillator market report ... analysis and forecast of revenue. This market was valued ... reach $623.6 million by 2018, at a CAGR of ... TOC of the North American crystal oscillator market report, ... This also provides a glimpse of the segmentation of ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 Currently ... Sartorius, A & D Weighing, Rice Lake, and ... Semi-Micro Balance . The Sartorius CPA Semi-Micro Balance ... affordable high-quality, precise, and user-friendly laboratory balance. , ... laboratory equipment, their laboratory balances are well known ...
Breaking Biology Technology:Researchers Report Thymosin Beta 4 Crosses Blood-Brain Barrier In Animal Stroke Model 2Report: Radical New IVD Test Approaches Key To Growth 2Report: Radical New IVD Test Approaches Key To Growth 3The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 2The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 3The North American crystal oscillator market is expected to reach $623.6 million by 2018 - New Report by MicroMarket Monitor 4Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 2Pipette.com Launches the Addition of Sartorius CPA Semi-Micro Balance to Their Product Portfolio with Special Promotional Pricing 3
... JERUSALEM, June 3 The Gamida Cell-Teva ... three in Barcelona and two in Valencia, have joined the Excel ... alphabetical order:, - Hospital Clinic of Barcelona, Barcelona, ... - Hospital Clinico Universitario de Valencia, Valencia, ...
... Imaging(R), Inc., a wholly owned subsidiary of Pro Medicus ... Advanced Radiology Consultants to provide its enterprise-wide Visage(R) CS. ... Advanced Radiology Consultants is a multi-modality, multi-site imaging organization ... year. , , Dr. Gerard Muro, Chief of ...
... a wholly owned subsidiary of Microfluidics International Corporation ... entered into an exclusive distributorship agreement whereby POWREX ... fluid processors in the pharmaceutical, biotechnology and energy ... the second-largest individual country pharmaceutical market in the ...
Cached Biology Technology:Five Cord Blood Transplant Centers in Catalonia and Valencia Join a Study to Test a New Technique to Treat Leukemia and Lymphoma 2Five Cord Blood Transplant Centers in Catalonia and Valencia Join a Study to Test a New Technique to Treat Leukemia and Lymphoma 3Visage Imaging to Provide Visage(R) CS Enterprise Wide Advanced Visualization Solutions to Advanced Radiology Consultants 2Microfluidics Expands Distributorship in Japan with Exclusive POWREX Partnership to Meet Increased Demand in Pharmaceutical, Biotechnology and Energy Industries 2Microfluidics Expands Distributorship in Japan with Exclusive POWREX Partnership to Meet Increased Demand in Pharmaceutical, Biotechnology and Energy Industries 3Microfluidics Expands Distributorship in Japan with Exclusive POWREX Partnership to Meet Increased Demand in Pharmaceutical, Biotechnology and Energy Industries 4
(Date:10/17/2014)... This news release is available in German . ... need millions of sperms every day in order to reproduce? ... questions are the topic of the latest issue of the ... 16th, 2014). The evolutionary biologist Steven Ramm from Bielefeld University ... nature, it is not unusual for a female to copulate ...
(Date:10/16/2014)... new synthesis of recent research findings to inform their ... two states. , The Ecology and Management of ... Synthesis of the Relevant Biophysical Science and Implications for ... the U.S. Forest Service,s Pacific Northwest Research Station, is ... a synthesis of the large body of scientific information ...
(Date:10/16/2014)... October 16, 2014 NXT-ID, Inc. (NASDAQ: ... a biometric authentication company focused on the growing mobile ... technologies including Wocket™, the Smart Wallet, at the 13 ... is a leading global conference on the intersection of ... Mark Anderson , founder and publisher of the ...
Breaking Biology News(10 mins):Sperm wars 2New report synthesizes best available science on management of moist mixed-conifer forests 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3
... Using a diverse herbicide application strategy may increase production ... practice will drastically reduce weeds and seeds that are ... glyphosate-resistant crops has led to weeds, such as marestail, ... in Roundup. Bill Johnson, a Purdue associate professor of ...
... University of Alberta now has a permanent connection to the agricultural ... A newly discovered fungus that helps plants grow in dry soil ... its help with the research. The fungus, now known as ... additional moisture and nutrients to the roots of nearby plants. Researchers ...
... Most of us are aware of the potential health benefits ... Now researchers are looking at how omega-3 may help laying ... million has been awarded to Dr John Tarlton of the ... of Clinical Veterinary Sciences by the Biotechnology and Biological Sciences ...
Cached Biology News:Herbicide diversity needed to keep Roundup effective 2Happier, healthier, more productive hens on omega-3? 2
... Progesterone Receptor (PR) Competitor Assay ... screening novel progesterone receptor binding compounds ... assay utilizes a fusion of glutathione ... of human progesterone receptor [PR-LBD(GST)] and ...
... pTriEx™ vectors combine the proven features of ... systems and provides all of the benefits ... one vector backbone. The pTriEx vectors have ... target genes in all three expression systems. ...
Rabbit polyclonal to Shigella Immunogen: Mixture of S. boydii, S. flexneri & S. dysenteriae....
... Cell Identification Kit. ALDEFLUORs ... substrate for the enzyme ... is highly expressed in ... making ALDH an extremely ...
Biology Products: