Navigation Links
New Method to Produce Blood Cells from Stem Cells Could Yield a Purer, Safer Cell Therapy
Date:7/12/2013

Durham, NC (PRWEB) July 12, 2013

A new protocol for reprogramming induced pluripotent stem cells (iPSCs) into mature blood cells, using just a small amount of the patient’s own blood and a readily available cell type, is reported on in the current issue of STEM CELLS Translational Medicine. This novel method skips the generally accepted process of mixing iPSCs with either mouse or human stromal cells during the differentiation process and, in essence, ensures no outside and potentially harmful DNA is introduced into the reprogrammed cells.

As such, it could lead to a purer, safer therapeutic grade of stem cells for use in regenerative medicine.

The discovery of iPSCs holds great promise for regenerative medicine since it is possible to produce patient-specific iPSCs from the individual for potential autologous treatment — that is, treatment using the patient’s own cells. This avoids the possibility of rejection and numerous other harmful side effects.

CD34+ cells are a type of blood stem cell that has been linked to proliferation. However, collecting enough CD34+ cells from a patient to produce an adequate amount of blood usually requires a large volume of blood to be taken from the patient. But scientists found a way around this, as outlined in the new study conducted by researchers in the Department of Medicine and Institute for Human Genetic, University of California-San Francisco. They were led by Yuet Wai Kan, M.D., FRS, and Lin Ye, Ph.D.

“We used Sendai viral vectors to generate iPSCs efficiently from adult mobilized CD34+ and peripheral blood mononuclear cells (MNCs),” Dr. Kan explained. “Sendai virus is an RNA virus that carries no risk of altering the host genome, so is considered an efficient solution for generating safe iPSC.”

“Just 2 milliliters of blood yielded iPS cells from which hematopoietic stem and progenitor cells could be generated. These cells could contain up to 4
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2 3

Related biology technology :

1. New method for producing precursor of neurons, bone and other important tissues from stem cells
2. UCLA team develops highly efficient method for creating flexible, transparent electrodes
3. New method for enhancing thermal conductivity could cool computer chips, lasers and other devices
4. New laboratory method uses mass spectrometry to rapidly detect staph infections
5. Novel method to make nanomaterials discovered
6. Cepheid Receives Grant to Develop Sample Processing and Amplification Methods for Detection of Bloodstream Bacteria
7. New method yields insulin-producing pancreatic cell clusters
8. X-BODY BioSciences to Present Novel Methods of Selecting for Antibodies Against Targets on Live Cells at CHIs Protein Engineering Summit
9. Fabrication method can affect the use of block copolymer thin films
10. New UCLA method quickly IDs nanomaterials that can cause oxidative damage to cells
11. Eutropics Pharmaceuticals Receives U.S. Patent for Novel Diagnostic Method
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... July 23, 2014 Shimadzu Scientific ... amino acid analysis system developed jointly with Ajinomoto ... Station can analyze 38 amino acids in nine ... Station achieves high-speed analysis utilizing a fast application-specific ... provides accurate analytical results even under conditions with ...
(Date:7/23/2014)... StemGenex® , the leading resource ... aimed at improving the lives of patients dealing with ... Parkinson’s disease. StemGenex believes that a commitment to ... paramount when providing care to patients with degenerative diseases. ... therapy accessible to the millions of individuals currently living ...
(Date:7/23/2014)... BRUSSELS , July 23, 2014 regulated ... its research and development pipeline with positive topline ... brivaracetam . This study was designed to evaluate ... (100 and 200 mg/day, without titration) compared to ... patients with partial-onset seizures, not fully controlled despite ...
(Date:7/23/2014)... 23, 2014 China Cord Blood Corporation (NYSE: ... leading provider of cord blood collection, laboratory testing, hematopoietic stem cell ... a multi-product healthcare company catering to the mother and child segment, ... patients across the PRC, Singapore , ... India , the Philippines and ...
Breaking Biology Technology:Shimadzu's New UF-Amino Station Provides High-Speed, Multi-Component Analysis of Amino Acids in Food & Beverage and Pharmaceutical Testing 2StemGenex® Gives Hope to Parkinson’s Patients through New Stem Cell Clinical Study 2StemGenex® Gives Hope to Parkinson’s Patients through New Stem Cell Clinical Study 3Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 2Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 3Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 4Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 5Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 6Major advance in UCB pipeline: positive topline Phase 3 results for brivaracetam in epilepsy patients with partial-onset seizures 7China Cord Blood Corporation and Cordlife Group Limited Announce Collaboration to Aid Asia-based Patients with Cord Blood Stem Cell Therapy 2China Cord Blood Corporation and Cordlife Group Limited Announce Collaboration to Aid Asia-based Patients with Cord Blood Stem Cell Therapy 3China Cord Blood Corporation and Cordlife Group Limited Announce Collaboration to Aid Asia-based Patients with Cord Blood Stem Cell Therapy 4
... Technology Council has published the first-ever magazine about ... the states research base, technology-transfer process, company creation, ... Corridor that joins Chicago, Wisconsin and Minneapolis-St. Paul. ... to post excerpts from Life Sciences: Wisconsin ...
... MADISON - While the memory inside electronic devices may often ... worsen over time. , ,Now a team of scientists ... understand why. The results are published in the early online ... ,Smart cards, buzzers inside watches and even ultrasound machines all ...
... annual Wisconsin Entrepreneurs Conference got off to a dynamic start ... least a hundred entrepreneurs and industry representatives to a crash ... entrepreneurial boot camp was designed serve both veteran and novice ... a panel of seasoned industrialists. , ,Our purpose is to ...
Cached Biology Technology:Life Sciences: Wisconsin - The Smart Choice Part Two 2Life Sciences: Wisconsin - The Smart Choice Part Two 3Life Sciences: Wisconsin - The Smart Choice Part Two 4Life Sciences: Wisconsin - The Smart Choice Part Two 5Life Sciences: Wisconsin - The Smart Choice Part Two 6Life Sciences: Wisconsin - The Smart Choice Part Two 7Engineers visualize electric memory as it fades 2Engineers visualize electric memory as it fades 3Entrepreneurs get crash course for building a successful company 2Entrepreneurs get crash course for building a successful company 3
(Date:7/23/2014)... (PHILADELPHIA) The Worldwide Innovative Networking in personalized cancer ... Kimmel Cancer Center at Thomas Jefferson University ... the only member of this prestigious group in the ... the delivery of innovative personalized medicine to the patient ... patient advocacy. , "Our participation in the WIN consortium ...
(Date:7/23/2014)... by 2050, according to one of the scenarios predicted ... be advantageous to the physiology and the biochemical and ... such as Stylosanthes capitata Vogel , a legume ... Brazil., The conclusion is from a study carried out ... Ribeiro Preto Faculty of Philosophy, Sciences and Languages and ...
(Date:7/23/2014)... starfish, and corals have in common? Aside from ... that use calcium from their environment to create ... protection. , The July issue of The ... Laboratory, addresses the challenges faced by these species ... carbon dioxide rises, the world,s oceans are becoming ...
Breaking Biology News(10 mins):New partnership brings more personalized cancer treatment to Philadelphia 2An increase in temperature by 2050 may be advantageous to the growth of forage plants 2An increase in temperature by 2050 may be advantageous to the growth of forage plants 3An increase in temperature by 2050 may be advantageous to the growth of forage plants 4Calcification in changing oceans explored in special issue of The Biological Bulletin 2
... air pollutant that harms humans and plants. Both climate and ... Researchers at the University of Gothenburg, Sweden, have now shown ... risk of ozone damage to plants in northern and central ... risk of ozone damage to vegetation is mainly due to ...
... German . When a cell divides, the ... to the daughter cells. Researchers at the Friedrich Miescher Laboratory ... a model organism. In cooperation with researchers at the University ... Aurora enzymes, which were already recognized as important cellular tools ...
... of engineers and scientists at the University of British Columbia ... eye for controlled and on-demand release of drugs to treat ... leading cause of vision loss among patients with diabetes. The ... in the retina, which in its advanced stages can result ...
Cached Biology News:Climate change increases the risk of ozone damage to plants 2New tasks attributed to Aurora proteins in cell division 2New tasks attributed to Aurora proteins in cell division 3UBC researchers invent new drug delivery device to treat diabetes-related vision loss 2
Polyclonal Antibody to Coronin / CORO1C This antibody was developed against synthetic peptides corresponding to amino acids 407-420 of human CORO1C....
Peptide-affinity Purified Polyclonal Antibody to Retinoic Acid-Induced 3 (RAI3/RAIG1)...
...
Co-precipitant is free of background polynucleotides,Dnases,Rnases, proteases. 20mg/ml...
Biology Products: