Navigation Links
New Method for Mass-Producing RPE Cells Paves Way to Treating Age-Related Blindness
Date:4/12/2013

Durham, NC (PRWEB) April 12, 2013

Scientists have developed a new, simpler way to produce human pluripotent stem cells in quantities large enough that they can be used to develop treatments for age-related macular degeneration — the leading cause of irreversible blindness among the elderly. The results of this new study are published in the current issue of STEM CELLS Translational Medicine.

Age-related macular degeneration (AMD), which affects up to 50 million people worldwide, is associated with the dysfunction and death of retinal pigment epithelial (RPE) cells.

“As a result, there has been significant interest in developing RPE culture systems both to study AMD disease mechanisms and to provide substrate for possible cell-based therapies. Because of their indefinite self-renewal, human pluripotent stem cells (hPSCs) have the potential to provide an unlimited supply of RPE-like cells,” noted Donald Zack, M.D., Ph.D., who with Julien Maruotti, Ph.D., led the team of researchers from the Wilmer Institute, Johns Hopkins University School of Medicine in Baltimore, Md., and the Institute of Vision in Paris in conducting the study.

“However, most of the currently accepted methods in use for deriving RPE cells from hPSC involve time-and-labor-consuming steps done by hand, and they don’t yield large enough amount of the differentiated cells – which has posed a problem when trying to use them to develop potential new therapies,” Dr. Maruotti added.

The Zack/Maruotti team simplified RPE cell production by modifying a standard protocol for isolating the cells from spontaneously differentiating hPSC monolayers. In the new method, hPSCs were amplified by clonal propagation and the RPE cells enriched by serial passage rather than mechanical picking.

“These modifications eliminate the need for the time- and labor consuming manual steps usually required to culture hPSCs and to purify the RPE popula
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2 3

Related biology technology :

1. New method for producing precursor of neurons, bone and other important tissues from stem cells
2. UCLA team develops highly efficient method for creating flexible, transparent electrodes
3. New method for enhancing thermal conductivity could cool computer chips, lasers and other devices
4. New laboratory method uses mass spectrometry to rapidly detect staph infections
5. Novel method to make nanomaterials discovered
6. Cepheid Receives Grant to Develop Sample Processing and Amplification Methods for Detection of Bloodstream Bacteria
7. New method yields insulin-producing pancreatic cell clusters
8. X-BODY BioSciences to Present Novel Methods of Selecting for Antibodies Against Targets on Live Cells at CHIs Protein Engineering Summit
9. Fabrication method can affect the use of block copolymer thin films
10. New UCLA method quickly IDs nanomaterials that can cause oxidative damage to cells
11. Eutropics Pharmaceuticals Receives U.S. Patent for Novel Diagnostic Method
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... , July 28, 2014  InterMune, Inc. (NASDAQ: ... its second quarter 2014 financial results at the close ... live conference call and webcast will be hosted by ... Interested investors and others may participate in ... 212-231-2900 (international), conference ID#21728775. A replay of the webcast and ...
(Date:7/28/2014)... Muncie, IN (PRWEB) July 28, 2014 ... Aeromodeling Center, in Muncie IN, is pleased to announce ... by the National Museum of the United States Air ... than a year-long process that concluded this spring with ... for the Dayton, OH museum. , The National ...
(Date:7/25/2014)... Calif. , July 25, 2014 Amgen ... of Directors today declared a $0.61 per share dividend ... be paid on Sept. 5, 2014, to all stockholders ... Aug. 14, 2014.  About Amgen Amgen ... patients suffering from serious illnesses by discovering, developing, manufacturing ...
(Date:7/25/2014)... 2014 Research and Markets  has ... Market 2014-2018" report to their offering. ... Metabolomics or Metabonomics is the scientific study of ... new experimental technique that is being widely used ... are small molecules that are present in blood, ...
Breaking Biology Technology:InterMune to Release Second Quarter Financial Results on August 6 2AMA’s National Model Aviation Museum Granted Full Civilian Museum Certification by the National Museum of the United States Air Force 2Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3Global Metabolomics Market 2014-2018: Key Vendors are Agilent, Bio-Rad, Bruker, Human Metabolome and Metabolon 2
... Thomson Reuters announced today the publication of a white ... in entering the Japanese generic drug market. , ... opportunities and strategies for success," notes that a combination ... aging population and wide-ranging government initiatives to reduce healthcare ...
... ROCKVILLE, Md., Oct. 1 Novavax, Inc. (Nasdaq: ... to the board,s corporate governance, compensation and finance committees, replacing ... member James Tananbaum who is retiring from the board. ... and immunology products companies and joined the Novavax board in ...
... BC, Oct. 1 /PRNewswire-FirstCall/ - avVaa World Health Care ... manufacturer and distributor of nationally branded therapeutic, natural skin ... launching their second test run of Neuroskin(R) Psoriasis Relief ... avVaa World Health Care Products will launch a two ...
Cached Biology Technology:Thomson Reuters Explores the Opportunities and Challenges of Entering the Japanese Generic Drug Market 2Thomson Reuters Explores the Opportunities and Challenges of Entering the Japanese Generic Drug Market 3Novavax Announces Board of Director Changes 2Novavax Announces Board of Director Changes 3avVaa World Health Care Products Inc. Announces Second DRTV Test Week 2avVaa World Health Care Products Inc. Announces Second DRTV Test Week 3
(Date:7/27/2014)... strike that wiped them out if it had taken ... , A fresh study using up-to-date fossil records and ... new narrative of the prehistoric creatures, demise, some 66 ... few million years before a 10km-wide asteroid struck what ... included extensive volcanic activity, changing sea levels and varying ...
(Date:7/27/2014)... have discovered a new species of mayfly in the southern ... India. In fact, this is the first time that any ... collected in peninsular India. , The new species, called ... Soldan for his substantial contribution to the understanding of the ... of a study that describes the new mayfly in the ...
(Date:7/27/2014)... have shown the potential for global climate change to ... most part, ignored the interactions between increasing temperature and ... to damage crops. , A new study involving researchers ... significant, suggesting that policymakers need to take both warming ... , The study looked in detail at global production ...
Breaking Biology News(10 mins):Dinosaurs fell victim to perfect storm of events, study shows 2Study: Climate change and air pollution will combine to curb food supplies 2Study: Climate change and air pollution will combine to curb food supplies 3
... Compared to European Americans, African Americans are four to five ... of African Americans with kidney failure have an increased risk ... a role in this skewed risk between races. Previous studies ... a role. The APOL1 gene creates a protein that is ...
... SAN FRANCISCO, Oct. 13, 2011 -- The tiny phytoplankton ... outsized role in drawing carbon from the atmosphere and sequestering ... as ocean water becomes warmer and more acidic, according to ... study published this week in the journal Global Change Biology, ...
... is a master builder. Using a bottom-up approach, nature ... materials, like diamonds, silicon and even table salt. In ... upon the type and arrangement of atoms within the ... University scientists has learned how to top nature by ...
Cached Biology News:Better ways to predict kidney disease risk for African Americans 2Better ways to predict kidney disease risk for African Americans 3Researchers explore plankton's shifting role in deep sea carbon storage 2Researchers explore plankton's shifting role in deep sea carbon storage 3Emulating -- and surpassing -- nature 2Emulating -- and surpassing -- nature 3
Human BMP 2 Construction Kit provides antigen affinity purified polyclonal capture and tracer antibodies, and antigen standard for development of approximately ten microplate assays....
...
... pAcGHLT-A,B,C Baculovirus ... Set,pAcGHLT-XylE Baculovirus ... Powder,Thrombin Dilution ... Cocktail,Insect Cell ...
...
Biology Products: