Navigation Links
New Method for Mass-Producing RPE Cells Paves Way to Treating Age-Related Blindness
Date:4/12/2013

Durham, NC (PRWEB) April 12, 2013

Scientists have developed a new, simpler way to produce human pluripotent stem cells in quantities large enough that they can be used to develop treatments for age-related macular degeneration — the leading cause of irreversible blindness among the elderly. The results of this new study are published in the current issue of STEM CELLS Translational Medicine.

Age-related macular degeneration (AMD), which affects up to 50 million people worldwide, is associated with the dysfunction and death of retinal pigment epithelial (RPE) cells.

“As a result, there has been significant interest in developing RPE culture systems both to study AMD disease mechanisms and to provide substrate for possible cell-based therapies. Because of their indefinite self-renewal, human pluripotent stem cells (hPSCs) have the potential to provide an unlimited supply of RPE-like cells,” noted Donald Zack, M.D., Ph.D., who with Julien Maruotti, Ph.D., led the team of researchers from the Wilmer Institute, Johns Hopkins University School of Medicine in Baltimore, Md., and the Institute of Vision in Paris in conducting the study.

“However, most of the currently accepted methods in use for deriving RPE cells from hPSC involve time-and-labor-consuming steps done by hand, and they don’t yield large enough amount of the differentiated cells – which has posed a problem when trying to use them to develop potential new therapies,” Dr. Maruotti added.

The Zack/Maruotti team simplified RPE cell production by modifying a standard protocol for isolating the cells from spontaneously differentiating hPSC monolayers. In the new method, hPSCs were amplified by clonal propagation and the RPE cells enriched by serial passage rather than mechanical picking.

“These modifications eliminate the need for the time- and labor consuming manual steps usually required to culture hPSCs and to purify the RPE popula
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2 3

Related biology technology :

1. New method for producing precursor of neurons, bone and other important tissues from stem cells
2. UCLA team develops highly efficient method for creating flexible, transparent electrodes
3. New method for enhancing thermal conductivity could cool computer chips, lasers and other devices
4. New laboratory method uses mass spectrometry to rapidly detect staph infections
5. Novel method to make nanomaterials discovered
6. Cepheid Receives Grant to Develop Sample Processing and Amplification Methods for Detection of Bloodstream Bacteria
7. New method yields insulin-producing pancreatic cell clusters
8. X-BODY BioSciences to Present Novel Methods of Selecting for Antibodies Against Targets on Live Cells at CHIs Protein Engineering Summit
9. Fabrication method can affect the use of block copolymer thin films
10. New UCLA method quickly IDs nanomaterials that can cause oxidative damage to cells
11. Eutropics Pharmaceuticals Receives U.S. Patent for Novel Diagnostic Method
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/22/2014)... 2014 Research and Markets ... DNA Diagnostics Market (Product types, Application, Technology, End ... Company Profiles, Demand, Insights, Analysis, Research, Report, Opportunities, ... to their offering. This new ... end users and Geography) Global Size, Industry Analysis, ...
(Date:10/22/2014)... Involution Studios , a healthcare software ... infographic, Understanding Ebola . The goal of ... to follow informative tool for anyone wanting to know ... prevention. , "As the news has spread in all ... represents not only a healthcare crisis with global impact, ...
(Date:10/22/2014)... (PRWEB) October 22, 2014 According ... Market by Service Type (Consulting, Integration, Deployment & ... by Deployment Model (Public, Private, Others (Hybrid & ... MarketsandMarkets, defines and segments the Cloud Professional Services ... and forecasting of revenues. It also identifies the ...
(Date:10/22/2014)... DIEGO and HONG KONG ... innovative rare disease therapeutics enterprise, announced today that rare ... the company as vice president, research. Dr. McKew brings ... including key leadership positions at the National Institutes of ... its acquisition by Wyeth). Dr. McKew will lead aTyr,s efforts ...
Breaking Biology Technology:Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 2Global DNA Diagnostics Market (Product types, Application, Technology, End User and Geography) - Forecast to 2020 3Involution Studios' Ebola Infographic Provides Key Disease Information and Statistics at a Glance 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 2Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 3Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 4Cloud Professional Services Market by Public, Private, Hybrid & Community Expected to Reach $34.41 Billion by 2019 - New Report by MarketsandMarkets 5aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 2aTyr Pharma Appoints John C. McKew, Ph.D., as Vice President, Research 3
... revenue growth ... Q3 2008 Highlights: - Product revenues ... - Direct (Non-OEM) Business revenues increased by 48% ... Calif., Oct. 27 Masimo Corporation,(Nasdaq: MASI ), the inventor of Pulse ...
... as Lead Epidemiologist, RALEIGH, N.C., Oct. 27 ... today the appointment of Dr.,Jerome Wilson as Senior ... Epidemiologist, Dr. Wilson is responsible for providing consulting,services ... PRA provides extensive Phase IV Post-Marketing services to,pharmaceutical ...
... JOSE, Calif., Oct. 27 HPSI (OTC Bulletin,Board: EROX) releases ... light of events that have shaken the investment community around ... to take this opportunity to update you as to ... Excluding technology advancements, an update of which will be ...
Cached Biology Technology:Masimo Reports Third Quarter 2008 Financial Results 2Masimo Reports Third Quarter 2008 Financial Results 3Masimo Reports Third Quarter 2008 Financial Results 4Masimo Reports Third Quarter 2008 Financial Results 5Masimo Reports Third Quarter 2008 Financial Results 6Masimo Reports Third Quarter 2008 Financial Results 7Masimo Reports Third Quarter 2008 Financial Results 8Masimo Reports Third Quarter 2008 Financial Results 9Masimo Reports Third Quarter 2008 Financial Results 10Masimo Reports Third Quarter 2008 Financial Results 11Masimo Reports Third Quarter 2008 Financial Results 12Masimo Reports Third Quarter 2008 Financial Results 13Jerome Wilson Joins PRA International's Late Phase Service Group 2Human Pheromone Sciences, Inc. - Shareholder Update 2Human Pheromone Sciences, Inc. - Shareholder Update 3
(Date:10/18/2014)... patients referred for evaluation of suspected genetic conditions, ... 25 percent, including detection of a number of ... disease, according to a study appearing in ... coincide with the American Society of Human Genetics ... or coding regions of thousands of genes simultaneously ...
(Date:10/17/2014)... news release is available in German . ... millions of sperms every day in order to reproduce? And ... are the topic of the latest issue of the research ... 2014). The evolutionary biologist Steven Ramm from Bielefeld University Bielefeld ... it is not unusual for a female to copulate with ...
(Date:10/16/2014)... constantly wages war on the human body. Battles ... stalemate. In pancreatic cancer, this stalemate—known as tumor ... aggressively malignant, a phenomena that is poorly understood. ... the laboratory of Salvatore Torquato, a Professor of ... conditions surrounding tumor dormancy and the switch to ...
Breaking Biology News(10 mins):Whole-exome sequencing shows potential as diagnostic tool 2Sperm wars 2Modeling tumor dormancy 2
... chemical processes in cells is dictated by the speed of ... a versatile method developed at the Institute of Physical Chemistry ... able to predict for the first time the diffusion coefficients ... is important not only for biologists and chemists, but also ...
... the first medication approved for the treatment of alcoholism ... part, by preventing the metabolism of an alcohol by-product, ... cause unpleasant symptoms, including nausea, vomiting, headache, and accelerated ... to avoid drinking. Beginning in the late ...
... alone were responsible for the demise of Australia,s iconic ... new study led by the University of Adelaide has ... study contradicts the widespread belief that disease must have ... thylacine was a unique marsupial carnivore found throughout most ...
Cached Biology News:Biologistics: How fast do chemical trains move in living cells? 2Biologistics: How fast do chemical trains move in living cells? 3Disulfiram: New support for an old addiction drug 2Disease not a factor in Tassie Tiger extinction 2
... Microarray Dot Blot Kits overcome this limitation ... over a wide range in low-density protein ... They are ideal for performing reverse-phase ... samples for the presence of low abundant ...
... easy-to-use kits for arraying proteins of ... common lab equipment. DiscoverLight Protein Array ... your protein, cell lysate or antibody ... kits include specially designed nitrocellulose membranes ...
Request Info...
... StabilZyme AP Conjugate Stabilizer is an ... bovine protein and other non-toxic stabilizing ... acid), pH 5.5 6.5. ... 0.02% methylisothiazolone and 0.02% bromonitrodioxane as ...
Biology Products: