Navigation Links
New HIV vaccine approach targets desirable immune cells
Date:9/1/2011

HIV have plagued HIV vaccine development," Liao said. "HIV hides its Achilles' heels of vulnerability on its outer coat by covering them with sugars. This covering is the result of virus mutations as the virus became resistant to antibodies."

The researchers found that the sugars on the natural HIV envelope prevented the envelope from binding to the immature B cell receptors that scientists want to trigger with a vaccine. So human and animal B cells fail to make antibodies against the HIV envelope's vulnerable spots when natural HIV envelope is injected as a vaccine candidate, even though these viral envelopes are the target of protective, neutralizing antibodies.

"We found that when you remove the sugars from the envelope proteins, you can create an envelope that targets those immature B cell receptors," said Haynes, who is also director of the DHVI.

"After the initial results, we completed a study in primates, which are similar to humans in terms of their genetics and their immune systems," Haynes said. "When they were given the HIV outer coat with many of the sugars removed, this sugar-depleted envelope bound better to the immature B cell receptors and stimulated antibodies better, which is a first step in the HIV-1 envelope activating an immature B cell target that previously it could not target."

Dimiter Dimitrov at the National Cancer Institute has previously shown that the natural HIV envelope protein frequently does not target immature B cells.

"The importance of this new finding is that it not only provides evidence for our hypothesis, but also for the first time it has identified envelope-based immunogens capable of binding to putative antibody germline predecessors that correlated with enhanced immunogenicity in animals," Dimitrov said.

Investigators have found that pathways for inducing the "right" kind of antibodies may be blocked or are unusual and are not routinely followed by HIV envelope-indu
'/>"/>

Contact: Mary Jane Gore
mary.gore@duke.edu
919-660-1309
Duke University Medical Center
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. GeoVax Awarded $3.6 Million Grant by U.S. Government for its HIV/AIDS Vaccine Program
2. Americans Travel to Mexico for Stem Cell Stimulation Therapies and E+ Peptide Cancer Vaccine -- Treatments Not Yet Offered in U.S.
3. Scientists take a step towards developing better vaccines for bluetongue
4. SEEK Announces Clinical Proof of Efficacy in HIV Vaccine Phase Ib/II Human Trial
5. Final countdown: Atlantis to carry next-generation vaccine candidate on last space voyage
6. Sorrento Therapeutics Innovative Approach to Developing Vaccines and Therapeutics for MRSA Receives Continued Support From the National Institute of Allergy and Infectious Diseases
7. New salmonella-based clean vaccines aid the fight against infectious disease
8. Inovio Pharmaceuticals DNA Vaccine for Foot-and-Mouth Disease Generates Protective Neutralizing Antibodies in Second Large-Animal Study
9. Inovio Pharmaceuticals Prostate Cancer DNA Vaccine Demonstrates Strong T Cell Responses in Monkeys; Company on Track for Phase I Clinical Trial
10. PharmAthene Achieves Anthrax Vaccine Program Milestone and Successfully Completes Technology Transfer
11. GeoVax Initiates Third Site For Therapeutic Testing of Its HIV Vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... 31, 2014 Having access to safe ... uphill battle in many corners of the globe. It’s ... community in northwestern Bolivia where many have been sickened ... from Fairfield University’s School of Engineering has been working ... Campesina (UAC), “the united college for the peasants.” A ...
(Date:10/31/2014)... Burlington, MA (PRWEB) October 31, 2014 ... is hosting a free learning webinar to introduce its ... managers, standards directors and biostatisticians. , Launched in September, ... the company's suite of clinical trial automation tools. For ... in a web browser. And by introducing Formations – ...
(Date:10/31/2014)... (PRWEB) October 31, 2014 Stronger ... healthcare, construction, finance and consumer electronics will help ... reason, industry research firm IBISWorld has added a ... its growing industry report collection. , The Biometrics ... for biometric technologies such as fingerprint, iris, retina ...
(Date:10/30/2014)... 30, 2014  Ardelyx, Inc. (NASDAQ: ... cardio-renal, gastrointestinal and metabolic diseases, today announced that ... on Thursday, November 6, 2014. Following the announcement, ... conference call and webcast at 4:30pm ET to ... business update. The live webcast can ...
Breaking Biology Technology:Fairfield University School of Engineering project reduces illness in rural community 2Fairfield University School of Engineering project reduces illness in rural community 3Formedix to Introduce "Revolutionary" Clinical Trial Automation Software with Learning Webinar 2Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 2Biometrics Scan Software in the US Industry Market Research Report Now Available from IBISWorld 3Ardelyx to Report Third Quarter 2014 Financial Results on November 6, 2014 2
... MDVN ) today announced several presentations at upcoming medical conferences that ... , 2009 American Urological Association (AUA) Annual Meeting, April 25-30, ... Podium presentation featuring MDV3100 on Sunday, April 26, ... , , , Dimebon ...
... California, April 23, deCODE genetics (NASDAQ: DCGN ... announced the signing of agreements under,which deCODE has ... for increased risk of major cardiovascular and metabolic,diseases, ... type 2,diabetes (T2D). These markers can be incorporated ...
... FOXA1 biomarker predicts likelihood of recurrence and long-term ... Company,s breast cancer menuALISO VIEJO, Calif., April 23 ... CLRT ), a premier anatomic pathology ... and the pharmaceutical industry, today announced that it ...
Cached Biology Technology:Medivation Announces Upcoming Scientific Presentations at Medical Conferences 2Medivation Announces Upcoming Scientific Presentations at Medical Conferences 3deCODE and Celera Partner to Expand use of deCODE Risk Markers for Heart Attack, Stroke and Diabetes 2deCODE and Celera Partner to Expand use of deCODE Risk Markers for Heart Attack, Stroke and Diabetes 3deCODE and Celera Partner to Expand use of deCODE Risk Markers for Heart Attack, Stroke and Diabetes 4deCODE and Celera Partner to Expand use of deCODE Risk Markers for Heart Attack, Stroke and Diabetes 5deCODE and Celera Partner to Expand use of deCODE Risk Markers for Heart Attack, Stroke and Diabetes 6deCODE and Celera Partner to Expand use of deCODE Risk Markers for Heart Attack, Stroke and Diabetes 7Clarient Granted Exclusive License to Commercialize Breast Cancer Biomarker by Indiana University Research and Technology Corporation 2Clarient Granted Exclusive License to Commercialize Breast Cancer Biomarker by Indiana University Research and Technology Corporation 3Clarient Granted Exclusive License to Commercialize Breast Cancer Biomarker by Indiana University Research and Technology Corporation 4Clarient Granted Exclusive License to Commercialize Breast Cancer Biomarker by Indiana University Research and Technology Corporation 5
(Date:10/30/2014)... soil subsidence and reduce greenhouse gas emissions, according ... by Dartmouth College researchers and their colleagues. , ... to continually measure the fluctuations of both carbon ... in the journal by Global Change ... organic soils has resulted in vast soil subsidence ...
(Date:10/30/2014)... 2014 – Bacteria in the gastrointestinal tract fulfill ... Yet, these same bacteria can induce strong inflammatory ... the gut and enter the bloodstream. , Although ... the body, chronic or systemic inflammation is linked ... established the involvement of inflammatory processes in the ...
(Date:10/29/2014)... a consequence of chemotherapy will benefit from a major ... that prevents hair loss. , The research is being ... cooling manufacturing company, Paxman Coolers, of Fenay Bridge, Huddersfield, ... of Huddersfield. , The research will be led by ... the pharmacology of cancer treatment, which he will use ...
Breaking Biology News(10 mins):Dartmouth study finds restoring wetlands can lessen soil sinkage, greenhouse gas emissions 2Breakdown in gut barriers to bacteria may promote inflammation and craving in alcoholics 2New technology on the way to aid cancer suffers who lose their hair after chemotherapy 2
... accepted by biologists that environmental factors cause the diversityor ... recent work, however, has suggested that species diversity continues ... new research on lizards in the Caribbean not only ... supplies, and competition for resources all work together to ...
... 20, 2010 TeamHealth Holdings, Inc. (NYSE: TMH), ... wellness program. The Apex Award, an honor ... UNH ), is presented to employers in recognition of ... was created to help TeamHealth employees adopt healthier lifestyles and ...
... The Damon Runyon Cancer Research Foundation, a non-profit ... named the first recipients of the Dale F. ... award provides additional funding to scientists completing a ... exceeded the Foundation,s highest expectations and are most ...
Cached Biology News:Research shows that environmental factors limit species diversity 2TeamHealth Receives UnitedHealth Group's Apex Award 2TeamHealth Receives UnitedHealth Group's Apex Award 3Damon Runyon Cancer Research Foundation awards breakthrough scientists 2
Anti-Mouse Ly 6C.2 , Ascites (Clone 5075-3.6) (mouse IgG2b)...
Goat polyclonal to SIAH Interacting Protein ( Abpromise for all tested applications)....
PKC (pSer345), phospho-specific...
Anti-ADAMTS-4, disintegrin-like domain Immunogen: Synthetic peptide - KLH conjugated Available Date: 38569...
Biology Products: