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Neuralstem Awarded Department of Defense Contract for Brain Cancer Research
Date:8/3/2011

ROCKVILLE, Md., Aug. 3, 2011 /PRNewswire/ -- Neuralstem, Inc. (NYSE Amex: CUR) announced it received a U.S. Department of Defense (DOD) contract to develop its human neural stem cell technology for the treatment of cancerous brain tumors. The research contract, entitled "Research to Treat Cancerous Brain Tumors with Neural Stem Cells," will be carried out in collaboration with Principal Investigator John Zhang, MD, PhD, Professor of Neurosurgery, Loma Linda University, in Loma Linda, CA. The contract award is $1.6 million for the first year of the project, of which Neuralstem will receive $625,000.  The DOD has three one-year options to continue the program after the first year based upon milestones.  The goal of the program is to have a therapeutic product for the treatment of cancerous brain tumors ready to submit to the FDA by the end of the fourth year (2015).

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"Current cancer therapies do not work on the majority of  brain tumors.  The prognosis for patients with a brain tumor such as glioblastoma is about 12 months of life," said Karl Johe, PhD, Neuralstem Chairman and Chief Scientific Officer. "We will be engineering our cells to attack brain cancer in three ways: first, by expressing an antibody known to suppress tumor growth; second, by expressing an enzyme that selectively kills tumor cells; and third by expressing an antiangiogenic protein that will starve the tumors by preventing the formation of the blood vessels that feed them.

"We believe that transplantation of our cells into the brain provides a unique route of administration through which to deliver these three anti-tumor therapies.  Neural stem cells are known to migrate to tumors and thus should be particularly well suited to the task.  Additionally, because we are transplanting the cells directly into
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SOURCE Neuralstem, Inc.
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