Navigation Links
Molecular machine could hold key to more efficient manufacturing
Date:1/10/2013

An industrial revolution on a minute scale is taking place in laboratories at The University of Manchester with the development of a highly complex machine that mimics how molecules are made in nature.

The artificial molecular machine developed by Professor David Leigh FRS and his team in the School of Chemistry is the most advanced molecular machine of its type in the world. Its development has been published in the journal Science.

Professor Leigh explains: "The development of this machine which uses molecules to make molecules in a synthetic process is similar to the robotic assembly line in car plants. Such machines could ultimately lead to the process of making molecules becoming much more efficient and cost effective. This will benefit all sorts of manufacturing areas as many manmade products begin at a molecular level. For example, we're currently modifying our machine to make drugs such as penicillin."

The machine is just a few nanometres long (a few millionths of a millimetre) and can only be seen using special instruments. Its creation was inspired by natural complex molecular factories where information from DNA is used to programme the linking of molecular building blocks in the correct order. The most extraordinary of these factories is the ribosome, a massive molecular machine found in all living cells.

Professor Leigh's machine is based on the ribosome. It features a functionalized nanometre-sized ring that moves along a molecular track, picking up building blocks located on the path and connecting them together in a specific order to synthesize the desired new molecule.

First the ring is threaded onto a molecular strand using copper ions to direct the assembly process. Then a "reactive arm" is attached to the rest of the machine and it starts to operate. The ring moves up and down the strand until its path is blocked by a bulky group. The reactive arm then detaches the obstruction from the
'/>"/>

Contact: Morwenna Grills
Morwenna.Grills@manchester.ac.uk
44-161-275-2111
University of Manchester
Source:Eurekalert

Page: 1 2

Related biology technology :

1. Scientists design, control movements of molecular motor
2. Study identifies targeted molecular therapy for untreatable NF1 tumors
3. Caris Sponsors CancerCare Connect Education Workshop on Molecular Profiling in the Treatment of Breast Cancer
4. Karmanos Cancer Center first in Midwest to offer latest Molecular Breast Imaging
5. Caris Life Sciences mejora la evaluación por perfil molecular con los biomarcadores ROS1 y MGMT-metilación
6. Caris Life Sciences Enhances Molecular Profiling Service with Addition of ROS1 and MGMT-Methylation Biomarkers
7. A firm molecular handshake needed for hearing and balance
8. USC Center For Applied Molecular Medicine To Honor Sumner Redstone And Murray Gell-Mann, Ph.D. At The Inaugural REBELS WITH A CAUSE Gala
9. Merrimack Pharmaceuticals To Present Preliminary Clinical Data For Novel Therapies Targeting Molecular Pathways In Advanced Cancers
10. Indian Pharma MNC Piramal Investing in German Molecular Imaging Technology
11. Spectrometry Market (Atomic, Molecular and Mass Spectrometry) - Global Scenario, Trends, Industry Analysis, Size, Share & Forecast 2011 - 2017
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/3/2015)... , March 3, 2015  Johnson & Johnson Innovation ... South San Francisco (JLABS @SSF), a 30,000-square ... South San Francisco, Calif. The Johnson ... to 50 startups from across the healthcare spectrum including ... The first resident startups have been selected, ...
(Date:3/3/2015)... 2015  Synthetic Biologics, Inc. (NYSE MKT: SYN), a developer ... focus on protecting the microbiome, announced today that Jeffrey ... the 27th Annual ROTH Conference being held on March 8-11, ... in Dana Point, CA. Mr. Riley ... 1:00 p.m. (Pacific Time). A live webcast of ...
(Date:3/3/2015)... March 03, 2015 GlobalStemCellsGroup.com ... faculty. Camacho Alcocer, a biomedical researcher and founding partner ... join GSCG’s team of biomedical professors who will teach ... , Criogenix SA de CV is a private company ... Institutions and Companies in Mexico (RENIECYT). , Camacho Alcocer ...
(Date:3/2/2015)... Md. (PRWEB) March 02, 2015 Shimadzu ... sessions and present on LCMS and marijuana analysis at ... place March 8 to 12 at the Ernest N. ... Attendees can stop by booth 3121 to discuss laboratory ... the company’s innovative, proven products help save time, money ...
Breaking Biology Technology:Johnson & Johnson Innovation Opens JLABS @South San Francisco and Announces First Five Resident Startups 2Johnson & Johnson Innovation Opens JLABS @South San Francisco and Announces First Five Resident Startups 3Johnson & Johnson Innovation Opens JLABS @South San Francisco and Announces First Five Resident Startups 4Johnson & Johnson Innovation Opens JLABS @South San Francisco and Announces First Five Resident Startups 5Synthetic Biologics to Present at the 27th Annual ROTH Conference 2Mario Camacho Alcocer Joins Global Stem Cells Group Faculty 2Mario Camacho Alcocer Joins Global Stem Cells Group Faculty 3Shimadzu Scientific Instruments Announces Product Launches, Presentations and Poster Sessions for Pittcon 2015 2Shimadzu Scientific Instruments Announces Product Launches, Presentations and Poster Sessions for Pittcon 2015 3
... and MONTREAL, Dec. 9 /PRNewswire-FirstCall/ - ProMetic Life ... subsidiary, ProMetic BioSciences Ltd ("PBL"), has signed a ... European Biopharmaceutical company estimated to be worth up ... with first shipment delivery starting this quarter. This ...
... KNDL ) a,leading, global full-service clinical research organization, ... Raymond James,Boston Fall Investors Conference. The conference will be ... in Boston on Dec. 11, 2008. Kendle,s,presentation is scheduled ... (Logo: ...
... Nile Therapeutics, Inc. (Nasdaq: NLTX ), today announced preliminary ... of CD-NP, a novel chimeric natriuretic peptide, in patients with heart failure. ... , , ... Blood pressure effects were dose dependent ...
Cached Biology Technology:ProMetic signs $35 M Long-term Supply Agreement with European Biopharmaceutical company 2ProMetic signs $35 M Long-term Supply Agreement with European Biopharmaceutical company 3Kendle to Present at the 2008 Raymond James Boston Fall Investors Conference 2Nile Therapeutics Announces Positive Results from Phase 1b Safety and Pharmacodynamics Study of CD-NP in Patients with Heart Failure 2Nile Therapeutics Announces Positive Results from Phase 1b Safety and Pharmacodynamics Study of CD-NP in Patients with Heart Failure 3Nile Therapeutics Announces Positive Results from Phase 1b Safety and Pharmacodynamics Study of CD-NP in Patients with Heart Failure 4Nile Therapeutics Announces Positive Results from Phase 1b Safety and Pharmacodynamics Study of CD-NP in Patients with Heart Failure 5
(Date:2/5/2015)... 26, 2015   Epic Sciences , a precision diagnostics ... that Murali Prahalad , Ph.D., president and CEO, is ... (PMWC) 2015: Silicon Valley, which is taking place at ... on January 26-28, 2015. Dr. ... as Biomarkers." Last year, Epic Sciences was a finalist in ...
(Date:2/5/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/6lngtl/global_biometrics ) ... Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, ... their offering. , In global ... anticipated to overtake North America ... towards IT security, government biometric based projects such ...
(Date:1/22/2015)... , Jan. 13, 2015 /PRNewswire/ - Today, FindBiometrics, the leading source ... launch of its new website design. "When we ... infancy", says Peter O,Neill , founder and CEO of ... industry needs involvement from the key players on a very ...
Breaking Biology News(10 mins):Epic Sciences to Present at Personalized Medicine World Conference 2015 on the Use of Circulating Tumor Cells as Cancer Biomarkers 2Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 2Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 3Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2
... surface of the earth, an influential community of microbes ... of those communities, scientists have now catalogued and compared ... the roots of the model plant Arabidopsis ... for examining how plants interact with a microbial community ...
... N.Y. -- In a curious evolutionary twist, several species of ... material from a virus into their genomes, according to new ... that several types of fruit fly -- scientific name ... for the sigma virus, a fly virus in the same ...
... MA -- The wrinkles on a raisin result from a ... stiff and buckles to accommodate its shrinking size. Now, a ... harness that same principle in a controlled and orderly way, ... basic method, they say, could be harnessed for a wide ...
Cached Biology News:Roots and microbes: Bringing a complex underground ecology into the lab 2Roots and microbes: Bringing a complex underground ecology into the lab 3Roots and microbes: Bringing a complex underground ecology into the lab 4Roots and microbes: Bringing a complex underground ecology into the lab 5In fly DNA, the footprint of a fly virus 2In fly DNA, the footprint of a fly virus 3Wrinkled surfaces could have widespread applications 2Wrinkled surfaces could have widespread applications 3
... The new StrepMAB-Immo coated microplates can ... immobilization of SerAla-Strep-tag II fusion proteins for ... Also small amounts of such proteins are ... (see graphic on the left) and will ...
Activating Agents, 7-azabenzotriazol-1-yloxy-tris-(pyrrolidino)phosphonium hexafluorophosphate...
The E. coli Expression System with Gateway Technology is designed to create E. coli expression clones containing the T7 promoter. The expression clones are ready for transformation and expression in ...
For use with SSP products or any application requiring agarose gel separation • Multiple formats available to meet various throughput needs • Includes replacement parts for each un...
Biology Products: